归脾汤加味治疗心脾气血两虚型冠心病室性早搏的临床研究

发布时间：2018-04-11 21:33

本文选题：归脾汤 + 室性早搏　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:临床观察比较归脾汤加味治疗心脾气血两虚型冠心病室性早搏的疗效及安全性,为中医药治疗心律失常提供思路和方法。方法:采用随机、对照的临床研究,将符合病例纳入标准的60例患者随机分为治疗组30例,对照组30例,在两组均给予冠心病基础治疗的基础上,试验组给予酒石酸美托洛尔和归脾汤加味治疗,对照组给予酒石酸美托洛尔治疗,2组均治疗4周后观察疗效,评价归脾汤加味治疗心脾气血两虚型室性早搏的临床疗效及其安全性。结果:室性早搏疗效:24h动态心电图室性早搏总有效率,试验组90.0%,对照组70.0%,室性早搏次数、疗效、严重程度分级,两组均有统计学差异(P0.05),试验组均优于对照组。冠心病疗效:冠心病心电图总有效率,试验组83.3%,对照组50.0%,试验组优于对照组;心电图ST段下移改变和心肌缺血总负荷改变,经过t检验,治疗前后组内分析均有差异(P0.01),治疗后组间分析为P0.05,有差异,试验组优于对照组。中医证候疗效:试验组总有效率93.3%,对照组83.3%;中医单项症状比较:试验组在改善心悸、胸闷、神疲乏力、失眠健忘等方面优于对照组(P0.01)。结论:本研究结果表明归脾汤加味治疗心脾气血两虚型冠心病室性早搏比单纯西药治疗效果更加明显,可有效减少室性早搏次数,改善心电图ST-T段变化和患者症状,改善患者生活质量,疗效确切,无不良反应发生,显示了中医药在治疗心律失常方面的优势,值得临床广泛应用。
[Abstract]:Objective: to compare the efficacy and safety of Guipi decoction in the treatment of ventricular premature beat of coronary heart disease with deficiency of heart and spleen qi and blood, and to provide ideas and methods for the treatment of arrhythmia with traditional Chinese medicine.Methods: 60 patients who met the criteria were randomly divided into treatment group (n = 30) and control group (n = 30).The experimental group was treated with metoprolol tartrate and Guipi decoction, the control group was treated with metoprolol tartrate for 4 weeks, and the control group was treated with metoprolol tartrate for 4 weeks.To evaluate the clinical efficacy and safety of Guipi decoction in the treatment of ventricular premature beats with deficiency of heart and spleen qi and blood.Results: the total effective rate of ventricular premature beat was 90.0 in the experimental group, 70.0in the control group, the times of ventricular premature beat, the curative effect and the severity of ventricular premature beat. There was significant difference between the two groups (P 0.05). The experimental group was superior to the control group.Effect of coronary heart disease: the total effective rate of ECG was 83.3 in the trial group and 50.0 in the control group, which was superior to that in the control group.Before and after treatment, there was significant difference between the two groups (P 0.01, P 0.05), and the test group was superior to the control group.The effect of TCM syndrome: the total effective rate of the test group was 93.3g, the control group 83.3.The comparison of the single symptoms of TCM: the experimental group was superior to the control group in improving palpitation, chest tightness, fatigue, insomnia and amnesia.Conclusion: the results of this study indicate that Guipi decoction is more effective than western medicine in the treatment of coronary heart disease with deficiency of both heart and spleen qi and blood. It can effectively reduce the number of ventricular premature beats and improve the changes of ST-T segment of ECG and the symptoms of the patients.To improve the quality of life of patients, the curative effect is definite, no adverse reactions occur, which shows the advantages of Chinese medicine in the treatment of arrhythmias, and is worthy of extensive clinical application.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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