消幽复胃汤治疗Hp耐药性慢性胃炎（脾胃湿热证）的临床观察

发布时间：2018-04-13 16:00

本文选题：慢性胃炎 + 脾胃湿热证　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察运用消幽复胃汤治疗Hp耐药性慢性胃炎脾胃湿热证患者的Hp根除情况及临床症状的改善情况,以探讨其临床价值。方法:本临床观察运用治疗前后自身对照的方法来进行研究,将40例经西医正规根除Hp方案治疗但Hp未根除,且经中医系统辨证为脾胃湿热证者纳入研究中,并以消幽复胃汤为治疗药物。每次服用剂量为150ml,于每日早饭前及晚饭后各30min服用,规定疗程为4周。疗程结束后,观察并记录患者治疗前后在中医证候积分上的具体变化情况。并至少在患者停药4周之后运用13C-UBT检测患者的Hp,以观察其Hp的根除率情况,全部数据收集完毕后,运用SPSS17.0统计软件进行系统分析。结果:纳入本研究的40例患者中有2例脱落,最终剩余38例患者完成研究。在Hp根除方面,共有20例患者的Hp被成功根除,根除率达到52.63%,且经检验分析后,得出χ2 = 27.14,且p0.01,可判断治疗前后Hp的根除情况具有显著差异性,具备统计学意义。在中医证候的临床疗效方面,其有效率为94.7%。在中医证候的各项积分及总积分方面,通过统计学系统分析,P值均0.01,可判断差异具备统计学意义。结论:1.消幽复胃汤对Hp耐药性慢性胃炎脾胃湿热证患者体内的Hp具备一定的根除作用。2.消幽复胃汤能够明显改善Hp耐药性慢性胃炎脾胃湿热证患者的中医临床症状,对胃脘有灼热感、口臭口苦、恶心欲呕及大便黏腻等症状的改善更为明显。
[Abstract]:Objective: to observe the eradication of HP and the improvement of clinical symptoms in patients with chronic gastritis with HP resistance.Methods: the clinical observation was carried out by using self-control method before and after treatment. Forty cases of HP eradication regimen were treated by western medicine, but HP was not eradicated, and the syndrome of spleen and stomach dampness and heat was identified as the syndrome of spleen and stomach dampness and heat by TCM system.And with Xiaoyou Fuwei decoction as the treatment drug.Each dose is 150ml. Take 30min before breakfast and after supper. The course of treatment is 4 weeks.After the course of treatment, observe and record the patients before and after treatment on the specific changes in TCM syndromes.At least 4 weeks after drug withdrawal, 13C-UBT was used to detect HP in order to observe the eradication rate of HP. After all the data were collected, SPSS17.0 statistical software was used for systematic analysis.Results: two of the 40 patients involved in the study had dropped off, and the remaining 38 patients had completed the study.In the aspect of HP eradication, a total of 20 patients were successfully eradicated, and the eradication rate was 52.63. After test and analysis, it was concluded that 蠂 2 = 27.14, and p0.01, it can be judged that the eradication of HP before and after treatment has significant difference and has statistical significance.The effective rate of TCM syndromes is 94. 7%.In the aspects of integral and total integral of TCM syndromes, the difference can be judged statistically by statistical systematic analysis of P value of 0.01.Conclusion 1.Xiaoyou Fuwei decoction has a certain eradication effect on HP in patients with HP resistance chronic gastritis, spleen and stomach dampness and heat syndrome.Xiaoyou Fuwei decoction can obviously improve the clinical symptoms of TCM in patients with chronic gastritis with HP resistance and chronic gastritis with dampness and heat of spleen and stomach. The improvement of symptoms such as burning heat in stomach, bitter breath, nausea and nausea, sticky stool and so on is more obvious.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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