健脾清热活血方治疗慢性萎缩性胃炎的临床观察

发布时间：2018-04-13 16:05

本文选题：慢性萎缩性胃炎 + 健脾清热活血方　；参考：《南京中医药大学》2017年硕士论文

【摘要】：研究目的通过运用导师自拟健脾清热活血方与胃复春片进行随机对照治疗CAG患者,观察其临床疗效、胃黏膜内镜表现及病理组织学的改善情况,客观评价健脾清热活血方的疗效,以推广其临床应用。研究方法选择60例经胃镜诊断为CAG的患者,随机分为两组,每组各30例,治疗组予健脾清热活血方口服,对照组予胃复春片口服,疗程6个月。治疗结束后复查胃镜,观察两组患者的治疗前后症状积分、胃镜及病理组织学等变化情况,数据整理后进行统计学分析。研究结果1.中医证侯总有效率:治疗组为93.33%,对照组为66.67%,差别有统计学意义(P0.05)。2.临床各症状方面:治疗组对胃胀、胃痛、嗳气、口苦口干的改善程度明显优于对照组(P0.01);对食少纳呆、吐酸嘈杂、痛有定处、乏力、大便不畅、大便稀溏、大便干燥等症状的缓解治疗组优于对照组(P0.05)。3.胃黏膜内镜表现及病理组织学方面:治疗组在改善萎缩、肠化、活动性炎症、慢性炎症方面优于对照组(P0.05),而在抗Hp感染、改善糜烂、胆汁反流方面两组疗效无明显差异(P0.05)。治疗组胃镜及病理总有效率为90.00%,对照组为63.33%,治疗组在改善患者胃镜及病理组织学方面优于对照组(P0.05)。研究结论通过两组病例的比较,在症状积分、胃黏膜内镜表现及病理组织学方面,治疗组优于对照组,且部分患者的萎缩和肠化得以逆转。由此可见,健脾清热活血方在改善CAG患者临床症状、胃镜及病理组织学上有较好的疗效,且安全性好,治疗过程中未出现不良反应。
[Abstract]:Objective to observe the clinical efficacy, endoscopic manifestations and histopathological improvement of CAG patients by using self-made Jianpi Qingre Huoxue recipe and Weifuchun tablet.Objective to evaluate the curative effect of Jianpi Qingre Huoxue recipe in order to popularize its clinical application.Methods 60 patients with CAG diagnosed by gastroscopy were randomly divided into two groups: 30 cases in each group. The treatment group was treated with Jianpi Qingre Huoxue recipe and the control group was treated with Weifuchun tablet for 6 months.After the treatment, the symptom score, gastroscope and histopathology of the two groups were observed, and the data were analyzed statistically.Results 1.The total effective rate of Hou in TCM syndrome was 93.33 in the treatment group and 66.67 in the control group.Clinical symptoms: the improvement of stomach distension, stomachache, belching and dry mouth in the treatment group was obviously better than that in the control group (P 0.01);The relief of stool dryness in the treatment group was better than that in the control group (P 0.05. 3).The endoscopic manifestations and histopathology of gastric mucosa in the treatment group were better than that in the control group in improving atrophy, intestinal metaplasia, active inflammation and chronic inflammation, but there was no significant difference between the two groups in anti-HP infection, improving erosion and bile reflux.The total effective rate of gastroscope and pathology was 90.00g in the treatment group and 63.33g in the control group. The treatment group was superior to the control group in improving the gastroscope and histopathology.Conclusion compared with the two groups, the treatment group is superior to the control group in terms of symptom score, endoscopic manifestations of gastric mucosa and histopathology, and the atrophy and intestinal metaplasia of some patients can be reversed.It can be seen that Jianpi Qingre Huoxue recipe can improve the clinical symptoms gastroscopy and histopathology of patients with CAG and has good safety and no adverse reaction in the course of treatment.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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