人体手指生物光子辐射及其与心气虚证的相关性探讨

发布时间：2018-04-15 05:24

本文选题：生物光子 + 检测技术　；参考：《山东中医药大学》2016年博士论文

【摘要】：目的:搭建人体生物光子辐射检测系统并进行性能调试和实验条件优化。研究健康人体7-70岁各年龄组手指末端光子辐射特征,探讨生物光子辐射表征机体状态的可能性,在此基础上进一步测试心气虚证患者手指末端生物光子辐射特征,分析健康以及心气虚证患者的生物光子辐射强度、光子计数分布等的差异,寻找可表征健康与心气虚证的光子辐射特征性参数,运用神经网络算法获取区分心气虚证患者和健康人体的生物光子辐射特征性参数组合和最佳测试部位。探讨生物光子表征中医证候的可能性,为证候的量化研究寻找一种符合中医思维的方法。方法:设计了人体超微弱发光检测系统的暗室、暗箱,制冷装置,选取了性能优良的光电倍增管、光子计数器,光子计数软件等,并对实验条件进行了优化。测试各年龄段健康人体和心气虚证患者的左右手手指末端的光子辐射强度,比较分析各年龄段健康人、健康人和心气虚证患者的十指光子强度、光子的Q值、光子的F值及Fano曲线的截距和斜率、压缩态参数|α|,θ,?,r,SSI等的异同,并且利用BP神经网络来评价不同手指发光特征和不同参数在心气虚证判别中的效率。结果:健康人体随年龄增长生物光子辐射强度呈S型增长;健康人各年龄段的Fano因子均值都大于1,Fano曲线的截距在1左右波动,各年龄组没有统计学差异,Fano曲线的斜率、光子辐射的Q值、压缩态参数等在不同年龄和不同手指有不同的变化特点。心气虚证患者与同龄健康对照,光子辐射强度明显降低;Fano曲线的斜率、光子辐射的Q值、压缩态参数等与同龄健康组比较表现为在某些手指上的变化,且这种变化有统计学意义。运用神经网络进一步分析,发现不同手指不同参数对心气虚证的判别效率不同。结论:搭建的人体生物光子检测系统性能好,测试条件稳定,符合实验条件要求;测试了251例7-70岁健康人体和30例51-60岁心气虚患者手指指尖光子辐射特点,得到了光子辐射强度随年龄变化的S型曲线,S型曲线是生物系统中常见的一种生长模型曲线。计算和分析了获得的9个参数,结果表明不同年龄组的同一手指、同一年龄组的不同手指、健康与心气虚证患者的同名手指,其光子辐射都有自己的特征,通过神经网络算法进一步找到了辨别心气虚证和健康人的光子辐射检测手指和最佳的光子辐射特征参数组合,即左手小指的光子辐射的各参数(strength,intercept,slope,SSI,Q,|α|,r,θ,φ)与心气虚证密切相关。
[Abstract]:Objective: to set up a human biological photon radiation detection system and optimize the performance and experimental conditions.To study the characteristics of photon radiation at the end of finger in healthy human body aged 7-70 years, and to explore the possibility of biological photon radiation to characterize the state of body. On this basis, the characteristics of biological photon radiation at the end of finger of patients with deficiency of heart qi were further tested.To analyze the differences of biological photon radiation intensity and photon counting distribution between healthy and patients with deficiency of heart qi, and to find the characteristic parameters of photon radiation that can be used to characterize the health and deficiency of heart qi.The neural network algorithm was used to obtain the combination of biological photon radiation characteristic parameters and the best test site to distinguish the patients with deficiency of heart qi from the healthy people.To explore the possibility of biological photons in characterizing TCM syndromes, and to find a method that accords with TCM thinking for the quantitative study of TCM syndromes.Methods: the dark chamber, dark box and refrigeration device of the human body ultraweak luminescence detection system were designed. The photomultiplier tube, photon counter and photon counting software were selected, and the experimental conditions were optimized.The photon radiation intensity at the end of the left and right fingers of healthy people and patients with deficiency of heart qi of all ages was measured, and the photon intensity of 10 fingers and the Q value of photons were compared and analyzed among healthy people of all ages, healthy people and patients with deficiency of heart qi.The F value of photons and the intercept and slope of Fano curve, the differences and similarities of squeezed state parameters 伪, 胃 and rSSI, etc. BP neural network is used to evaluate the luminous characteristics of different fingers and the efficiency of different parameters in judging the deficiency of heart qi.Results: the biophoton radiation intensity of healthy people increased with age, the mean of Fano factor in all age groups was larger than that of 1 Fano curve, the intercept of Fano curve fluctuated around 1, and there was no statistical difference in slope of Fano curve among different age groups.The Q value and squeezing state parameters of photon radiation vary with different ages and fingers.The intensity of photon radiation decreased significantly the slope of Fano curve, the Q value of photon radiation, the parameters of compressed state, and so on compared with those of the same age healthy group.And this change has statistical significance.Further analysis using neural network showed that different finger and different parameters had different discriminating efficiency on deficiency of heart qi.Conclusion: the established human biological photon detection system has good performance, stable testing conditions and meets the requirements of the experiment, and has tested the characteristics of finger finger photon radiation in 251 healthy people aged 7-70 years and 30 patients aged 51-60 years with heart qi deficiency.The S-shaped curve of photon radiation intensity varying with age is a common growth model curve in biological system.Nine parameters were calculated and analyzed. The results showed that the same finger of different age group, different finger of the same age group, and the same finger of healthy and heart qi deficiency patients had their own characteristics of photon radiation.The neural network algorithm was used to find out the best combination of photon radiation characteristic parameters, I. e., the parameters of photon radiation of left paunch finger and that of the healthy people. The parameters of photon radiation of left hand pinky finger are closely related to the syndrome of deficiency of heart qi. The parameters of SSIQ, 伪 r, 胃, 蠁) are closely related to each parameter of photon radiation of left hand pinky finger.
【学位授予单位】：山东中医药大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R228

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