健脾益肾汤治疗IgA肾病脾肾两虚型的临床观察

发布时间：2018-04-15 09:16

  本文选题：IgA肾病 + 健脾益肾汤　； 参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察健脾益肾汤治疗IgA肾病的临床疗效,为中医药治疗IgA肾病提供临床依据。方法:将符合纳入标准的46例IgA肾病患者,给予健脾益肾汤进行治疗,疗程为3个月,观察患者治疗前后的中医症状积分、尿蛋白、尿沉渣镜检红细胞计数、24小时尿蛋白定量、血浆白蛋白、血肌酐、血尿酸、血清胱抑素C等实验室指标以及IgA肾病预后系统评分积分的变化,应用SPSS17.0统计软件进行统计学分析。结果:1、本临床观察共46例IgA肾病患者,治疗3个月后综合疗效总有效率为84.78%,中医症状疗效总有效率为95.65%,中医症状积分较治疗前减小明显(P0.05)。2、治疗后尿蛋白、尿沉渣镜检红细胞计数、24小时尿蛋白定量、血清胱抑素C、收缩压较治疗前均明显降低(P0.05),血浆白蛋白升高(P0.05)。治疗后血肌酐、血尿酸较治疗前变化无统计学意义(P0.05)。3、治疗后IgA肾病预后系统评分积分降低显著(P0.05)。结论:1、健脾益肾汤可改善IgA肾病患者的临床症状。2、健脾益肾汤可降低IgA肾病患者血尿、蛋白尿水平,提高血清白蛋白水平。3、健脾益肾汤可降低IgA肾病患者血清胱抑素C水平,对IgA肾病早期肾功能下降有改善作用。4、健脾益肾汤可减小IgA肾病患者预后评分,降低本病进展为ESRD的风险。
[Abstract]:Objective: to observe the clinical effect of Jianpi Yishen decoction on IgA nephropathy and to provide clinical basis for TCM treatment of IgA nephropathy.Methods: 46 patients with IgA nephropathy were treated with Jianpi Yishen decoction for 3 months. The scores of TCM symptoms, urine protein and erythrocyte count were observed before and after treatment.The changes of plasma albumin, serum creatinine, serum uric acid, serum cystatin C and prognosis system score of IgA nephropathy were analyzed by SPSS17.0 software.Results: in this clinical study, 46 patients with IgA nephropathy were observed. After 3 months of treatment, the overall effective rate was 84.78, the total effective rate of TCM symptom was 95.655.The score of TCM symptom decreased significantly compared with that of before treatment.Urine sediment microscopic examination of erythrocyte count and 24 hours urine protein quantity, serum cystatin C, systolic blood pressure were significantly lower than before treatment, plasma albumin increased P0.05N.There was no significant change in serum creatinine and uric acid after treatment compared with that before treatment (P 0.05). After treatment, the score of prognosis system score of IgA nephropathy decreased significantly (P 0.05).Conclusion: 1, Jianpi Yishen decoction can improve the clinical symptoms of IgA nephropathy patients. Jianpi Yishen decoction can reduce the level of hematuria and proteinuria in IgA nephropathy patients, and increase the serum albumin level. The Jianpi Yishen decoction can reduce the level of serum cystatin C in IgA nephropathy patients.It can improve the decline of renal function in early stage of IgA nephropathy. 4. Jianpi Yishen decoction can reduce the prognosis score of patients with IgA nephropathy and reduce the risk of progression to ESRD.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5

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