皮肌炎中医证型与调节性T淋巴细胞的相关性

发布时间：2018-04-17 08:40

本文选题：皮肌炎 + 中医证型　；参考：《中国皮肤性病学杂志》2017年02期

【摘要】：目的观察皮肌炎(DM)患者不同中医证型与外周血调节性T细胞(Treg)的关系。方法 149例确诊DM的患者分为热毒炽盛证、湿热蕴结证、寒湿痹阻证、脾肾两虚证、肝肾阴虚证,采用流式细胞术检测外周血Treg比例,研究其与中医证型病情活动相关性。并设118例健康对照组。结果热毒炽盛证、湿热蕴结证患者血Treg百分率显著低于其他组,差异有统计学意义(P0.05);寒湿痹阻证血Treg百分率低于脾肾两虚证、肝肾阴虚证、健康对照组,差异有统计学意义(P0.05);脾肾两虚证、肝肾阴虚证患者血Treg百分率与健康对照组的比较差异无统计学意义(P0.05)。结论 DM患者的中医证型与其免疫功能状态存在关联。
[Abstract]:Objective to observe the relationship between different TCM syndromes and peripheral blood regulatory T cell Tregs in patients with dermatomyositis.Methods 149 patients with DM were divided into heat toxin syndrome, damp-heat accumulation syndrome, cold dampness stagnation syndrome, spleen and kidney deficiency syndrome, liver and kidney yin deficiency syndrome. The proportion of peripheral blood Treg was detected by flow cytometry, and the correlation with TCM syndrome activity was studied.118 cases of healthy control group were set up.Results the percentage of blood Treg in patients with hyperthermia and damp-heat accumulation syndrome was significantly lower than that in other groups (P 0.05), the percentage of blood Treg in cold dampness obstruction syndrome was lower than that in spleen and kidney deficiency syndrome, liver and kidney yin deficiency syndrome, and healthy control group.The difference was statistically significant (P 0.05), and there was no significant difference in the percentage of blood Treg between the patients with deficiency of spleen and kidney and the patients with yin deficiency of liver and kidney compared with the healthy control group (P 0.05).Conclusion the TCM syndromes of DM patients are related to their immune function.
【作者单位】：河北医科大学附属平安医院(石家庄平安医院)风湿科;河北省辛集市中医院;
【基金】：河北省中医药管理局科研计划项目(2013223)
【分类号】：R259

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