2型糖尿病合并认知功能障碍的中医证型与影响因素的相关分析

发布时间：2018-04-18 07:22

本文选题：2型糖尿病 + 认知功能　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:本研究旨在探讨糖尿病合并认知功能障碍的中医证候分布规律,并对2型糖尿病合并认知功能障碍的影响因素进行分析,为临床辨证治疗提供参考依据。材料与方法:按照1999年世界卫生组织(WHO)推荐的糖尿病分型及诊断标准,随机纳入住院2型糖尿病患者124例。应用简易智力状况检查法(MMSE)及蒙特利尔认知评估量表(Mo CA)进行测评,按评定标准将其分为糖尿病认知障碍组63例与糖尿病非认知障碍组61例。收集完整的患者四诊资料,以《中医诊断学》7版教材为主,并参照2002年《中药新药临床研究指南原则(试行)》及2005年颁发的《中国中西医结合糖尿病诊疗标准》,对糖尿病合并认知功能障碍组患者进行辨证诊断,探讨2型糖尿病合并认知功能障碍患者的证候规律。应用统计学方法比较两组的一般资料及临床资料,并根据MMSE评分结果,分析2型糖尿病合并认知功能障碍的影响因素与认知功能的相关性。结果:1.2型糖尿病(T2DM)合并认知功能障碍(CI)患者证候以瘀血阻络型居多,共计25例,占39.7%,其他证候依次为心脾两虚型、湿热困脾型、阴虚火旺型、气阴两虚型、阴阳两虚型、肝肾两虚型。分别占17.5%、12.7%、12.7%、9.5%、4.8%、3.2%。2.T2DM合并CI的年龄、病程、糖化血红蛋白(Hb A1c)及尿酸(UA)水平明显高于糖尿病无认知功能障碍组(NCI),受教育年限明显低于糖尿病无认知功能障碍组,糖尿病相关并发症合并情况明显高于NCI组,差异有统计学意义(P0.05);认知功能与病程、Hb A1c、TG及BUA水平合并下肢动脉硬化情况成负相关,与受教育年限成正相关。结论:1.T2DM合并CI的中医证候可能以瘀血阻络为主。2.T2DM患者的年龄,病程,受教育程度,Hb A1c,TG,UA水平及糖尿病并发症是CI的重要影响因素。
[Abstract]:Objective: the distribution of TCM Syndromes of this study is to investigate the cognitive dysfunction of diabetes mellitus, and the influencing factors of type 2 diabetes mellitus with cognitive dysfunction analysis, provides the reference for the clinical diagnosis and treatment. Materials and methods: according to the 1999 WHO (WHO) recommended type of diabetes and the diagnostic criteria, randomly in hospitalized patients with type 2 124 cases of diabetes. The application of Mini Mental State Examination (MMSE) and Montreal cognitive assessment (Mo CA) were assessed according to the evaluation criteria will be divided into groups of 63 cases with diabetic cognitive impairment in diabetic non cognitive disorder group 61 cases. Patients with complete clinical data collection, with < TCM diagnostics >7 edition textbook in 2002, according to "Chinese medicine clinical research guideline principle (Trial) > > and the combination of diabetes diagnosis standard issued in 2005" China of traditional Chinese medicine and Western medicine combined with cognitive function of diabetes Disorder group were diagnosis, study in patients with type 2 diabetes mellitus patients with cognitive impairment syndromes. The general data and clinical data were compared in the two groups, and according to the results of MMSE score, analysis of the impact of type 2 diabetes mellitus with cognitive dysfunction related to cognitive function. Results: type 1.2 diabetes mellitus (T2DM) cognitive dysfunction (CI) patients with blood stasis syndrome in the majority, a total of 25 cases, accounting for 39.7%, other syndromes are deficiency of two, damp spleen type, hyperactivity of fire due to yin deficiency, deficiency of Qi and Yin, yin and yang two deficiency, liver and kidney deficiency type accounted for 17.5%. Two, 12.7%, 12.7%. 9.5%, 4.8%, 3.2%.2.T2DM CI with age, disease duration, glycosylated hemoglobin (Hb A1c) and uric acid (UA) levels were significantly higher than that of patients without cognitive dysfunction group (NCI), number of years of education was significantly lower than diabetic cognitive dysfunction group, diabetes mellitus Related complications in patients was significantly higher than that of NCI group, the difference was statistically significant (P0.05); cognitive function and duration of Hb, A1c, TG and BUA levels in patients with lower extremity arteriosclerosis negatively related to positive correlation with education. Conclusion: TCM Syndromes of 1.T2DM and CI in blood stasis based.2.T2DM patients age, course of disease, education level, Hb, A1c, TG, UA levels and diabetic complications are important influencing factors of CI.

【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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