芪地复肾汤治疗慢性肾小球肾炎蛋白尿（脾肾气虚证）的临床研究

发布时间：2018-04-19 09:41

本文选题：芪地复肾汤 + 慢性肾小球肾炎　；参考：《长春中医药大学》2016年硕士论文

【摘要】：目的:观察芪地复肾汤治疗CGN蛋白尿脾肾气虚证的临床疗效。方法:收集2014年6月至2015年12月吉林省人民医院中医科、肾病科门诊及疗区患者病人,入选患者均符合CGN的临床诊断,共纳入80例,研究过程中脱落8例,最终研究病例72例。所有患者随机分为中药治疗组、对照组各36例。所有患者均予以一般基础治疗,中药治疗组治疗方案:给予芪地复肾汤(采用三九药业生产的中药免煎制剂),按照原饮片量调剂,水冲300 ml,每日1剂,早饭前、晚饭后分服;对照组治疗方案:给予洛汀新10 mg,每日1次。两组观察时间为12周。对比两组患者治疗后尿蛋白水平、中医症状变化,评价两组整体疗效。结果:经治后,中药治疗组患者治愈7例,显效15例,有效12例,总有效率为94.4%,明显优于对照组(P0.05),差异有统计学意义;两组患者中医主证均有不同程度好转,在浮肿、乏力、便溏、纳差等方面,中药治疗组的好转程度明显优于对照组(P0.05),差异有统计学意义;对24 h尿蛋白定量进行比较,两组经治后均有一定的降蛋白作用,中药治疗组明显优于对照组(P0.05);中药治疗组尿蛋白水平下降效果明显优于对照组(P0.05),差异有统计学意义;治疗前后两组的AST、ALT、BUN及SCr比较差异无统计学意义(P0.05);两组治疗前后血常规、粪常规检查均未见明显异常。研究过程中,两组均未见不良反应。结论:芪地复肾汤可有效降低CGN脾肾气虚证患者蛋白尿水平,改善慢性肾炎的临床症状,提高患者生存质量。本研究观察应用芪地复肾汤对肝、肾功能未见明显影响,未见明显不良反应,安全性较好。
[Abstract]:Objective: to observe the clinical effect of Qidi Fushen decoction in treating CGN proteinuria with deficiency of spleen and kidney qi.Methods: from June 2014 to December 2015, the patients in the Department of traditional Chinese Medicine, the Department of Renal Diseases and the treatment area of Jilin Provincial people's Hospital were collected. All the patients were selected according to the clinical diagnosis of CGN, including 80 cases, 8 cases were lost in the course of the study, and 72 cases were finally studied.All patients were randomly divided into Chinese medicine treatment group, the control group of 36 cases.All the patients were given general basic treatment, the Chinese medicine treatment group was given Qidi Fushen decoction (using Sanjiu pharmaceutical industry production of Chinese medicine free decoction preparation, according to the original decoction volume, 300 ml water, 1 dose per day, before breakfast, after supper;The control group was treated with Lotensin 10 mg once a day.The observation time was 12 weeks.The urine protein level and TCM symptoms were compared between the two groups after treatment, and the overall curative effect of the two groups was evaluated.Results: after treatment, 7 cases were cured, 15 cases were effective, 12 cases were effective, the total effective rate was 94.44.The total effective rate was 94.44.The difference was statistically significant.In the aspects of loose stools and poor anorexia, the improvement of TCM treatment group was significantly better than that of control group (P 0.05), and the difference was statistically significant.The Chinese medicine treatment group was obviously superior to the control group (P 0.05A), the Chinese medicine treatment group had significantly better effect than the control group (P 0.05) in decreasing the urine protein level, the difference between the two groups was statistically significant, there was no significant difference between the two groups in AST alt bun and SCr before and after treatment, and there was no significant difference in blood routine before and after treatment between the two groups, and there was no significant difference between the two groups before and after treatment.No obvious abnormality was found in routine examination of feces.In the course of the study, no adverse reactions were observed in either group.Conclusion: Qidi Fushen decoction can effectively reduce the level of proteinuria in CGN patients with deficiency of spleen and kidney qi, improve the clinical symptoms of chronic nephritis and improve the quality of life of the patients.In this study, Qidi Fushen decoction had no obvious effect on liver and kidney function, no obvious adverse reaction, and good safety.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

【相似文献】