参夏加桂合剂治疗冠心病稳定型心绞痛的临床疗效观察

发布时间：2018-04-20 02:11

本文选题：冠心病 + 稳定型心绞痛　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:本文旨在应用导师的经验方“参夏加桂合剂”治疗冠心病-稳定型心绞痛(心阳不足、痰瘀阻络证),并比较患者年龄、BMI等基本信息,血脂、凝血功能等血液变化,中医症状分级量表、西雅图心绞痛量表和心电图疗效等方面的变化,观察临床疗效。方法:本课题选取符合纳入标准的患者60例,并随机分为对照组和治疗组,每组30例。所有60例患者均给予西药拜阿司匹灵、鲁南欣康、立普妥基础治疗。治疗组则在基础治疗上加服参夏加桂合剂,日一剂;对照组只给基础治疗。两个治疗组治疗疗程都是8周,期间如出现意外情况当给予对症处理。治疗前和8周后分别观察治疗组和对照组在中医症状、躯体活动受限程度、心绞痛稳定状态、心绞痛发作状况等方面的变化,并对血脂中总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)等指标及凝血指标进行比较。结果:治疗组患者在中医症状、躯体活动受限程度(PL)、心绞痛稳定状态(AS)、心绞痛发作情况(AF)、心电图疗效、治疗满意程度(TS)等方面改善效果良好,和对照组数据比较发现,P0.05,具有显著差异。在TC、TG、LDL-C、Fib及PT等血液变化方面,治疗组和对照组比较,P0.05,有统计学意义。结论:1.参夏加桂合剂能够有效的减少心绞痛的发作次数,减轻发作时的不适症状,能够更好、更全面的改善本病的发病状态和伴随症状;2.参夏加桂合剂能够全方位的提高患者的生活质量,更好的改善患者的发作症状、减少发作,从而提高日常活动耐量、增加治疗满意度;3.参夏加桂合剂可更有效地改善冠心病患者的心电图;4.参夏加桂合剂能够有效地调节血脂水平,降低血液粘稠度,更好地预防心绞痛的发作,更有效的控制冠心病的进展;5.参夏加桂合剂可较好的改善凝血水平。
[Abstract]:Objective: the purpose of this study was to apply "Shenxia Jiangui mixture" to treat coronary heart disease (CHD)-stable angina pectoris (deficiency of heart yang, phlegm stasis obstruction of collaterals syndrome), and to compare the basic information of age and BMI, blood lipid, coagulation function, and so on, in the treatment of coronary heart disease and stable angina pectoris. The clinical effects of TCM symptom scale, Seattle angina scale and electrocardiogram were observed. Methods: 60 patients who met the inclusion criteria were randomly divided into control group and treatment group with 30 cases in each group. All the 60 patients were treated with western medicine Beaspinone, Lunan Xinkang and Lipitor. The treatment group was treated with Shenxiajiangui mixture, and the control group was given basic treatment only. The course of treatment in both groups is 8 weeks, during which time, if an accident occurs, symptomatic treatment should be given. Before and 8 weeks after treatment, the changes of TCM symptoms, restricted physical activity, stable state of angina pectoris and angina pectoris attack were observed in the treatment group and the control group, respectively. Serum total cholesterol cholesterol (TC), triglyceride triglyceride (TG), low density lipoprotein (LDL-C) and low density lipoprotein (LDL-C) were compared. Results: in the treatment group, the symptoms of TCM, the degree of restricted somatic activity, the stable state of angina pectoris, the incidence of angina pectoris, the curative effect of electrocardiogram and the degree of satisfaction with treatment were improved well. Compared with the control group, it was found that P0. 05 had significant difference. There was significant difference between the treatment group and the control group in blood changes such as LDL-Cfib and PT. Conclusion 1. Shenxiajiangui mixture can effectively reduce the number of angina pectoris attack, relieve the symptoms of the attack, can be better, more comprehensive improvement of the state of the disease and associated symptoms. 2. Shenxiajiangui mixture can improve the quality of life of patients, improve the attack symptoms, reduce attacks, improve daily activity tolerance, and increase treatment satisfaction. Shenxia Jiangui mixture can improve electrocardiogram more effectively in patients with coronary heart disease. Shenxiajiangui mixture can effectively regulate blood lipid level, reduce blood viscosity, better prevent angina pectoris attack, more effective control of the progress of coronary heart disease. 5. Shenxia Jiangui mixture can improve coagulation level.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【引证文献】