经皮穴位电刺激治疗肝肾阴虚型围绝经期综合征的临床疗效观察

发布时间：2018-04-20 05:13

本文选题：围绝经期综合征 + 经皮穴位电刺激　；参考：《浙江中医药大学》2017年硕士论文

【摘要】：目的通过与电针组的随机对照研究,观察经皮穴位电刺激治疗肝肾阴虚型围绝经期综合征的临床疗效及安全性、患者接受度评价。方法将符合纳入标准的64例肝肾阴虚型围绝经期患者随机分成两组,经皮组和电针组各32例。两组选穴相同,均为双侧天枢、子宫、三阴交和太溪。两组治疗周期均为隔日1次,每周3次,4周为一疗程。两组在治疗前后及3个月随访后观察改良的Kupperman评分(KI评分)、围绝经期生存质量量表(MENQOL)、血清E2、FSH的变化以及临床整体疗效的比较,并对其进行安全性、患者接受度评价。结果(1)一般资料比较:两组患者在年龄、病程、已绝经患者比例上差异无统计学意义(P0.05),患者基本情况一致,具有可比性。(2)基线比较:治疗前,两组在KI评分、血管舒缩症状积分、精神神经症状积分、MENQOL量表评分以及血清E2、FSH水平均无统计学差异(P0.05)。(3)组内比较:两组治疗后、治疗结束3个月后随访在KI评分、血管舒缩症状积分、精神神经症状积分、MENQOL量表评分上与治疗前相比,差异有统计学意义(P0.05);在血清E2水平上,两组治疗后较治疗前差异有统计学意义(P0.05),但治疗结束3个月后较治疗前差异无统计学意义(P0.05);在血清FSH水平上,两组治疗后、治疗结束3个月后较治疗前差异无统计学意义(P0.05)。(4)组间比较:两组治疗后、治疗结束3个月后随访在KI评分、血管舒缩症状积分、精神神经症状积分、MENQOL量表评分以及血清E2、FSH水平上差异均无统计学意义(P0.05);两组整体有效率差异无统计学意义(P0.05);两组在安全性、患者接受度上差异有统计学意义(P0.05)。结论经皮穴位电刺激和电针均能改善围绝经期综合征患者的临床症状,提高围绝经期综合征患者的生存质量;经皮穴位电刺激改善围绝经期综合征患者的临床症状,提高患者生存质量方面与电针组相较未见明显差异,远期疗效亦相当;经皮穴位电刺激和电针均能提高围绝经期综合征患者的E2水平,但远期效果不佳,经皮穴位电刺激和电针对围绝经期综合征患者的FSH水平无显著改善;经皮穴位电刺激的安全性、患者接受度优于电针治疗。
[Abstract]:Objective To observe the clinical efficacy and safety of percutaneous acupoint electric stimulation in the treatment of perimenopausal syndrome of yin deficiency of liver and kidney, and to evaluate the patient's acceptance. Methods 64 cases of perimenopausal patients with deficiency of liver and kidney Yin type were randomly divided into two groups, 32 cases each of the percutaneous group and the electroacupuncture group, and the two group selection phase. The two groups were both bilateral Tianshu, uterus, Sanyinjiao and Tai Xi. The two groups were 1 times a day, 3 times a week and 4 weeks as a course of treatment. The two groups were followed up before and after treatment and 3 months followed up to observe the improved Kupperman score (KI score), the perimenopausal quality of life scale (MENQOL), the changes of serum E2, FSH, and the comparison of the clinical overall effect. Safety, patient acceptance evaluation. Results (1) general data comparison: two groups of patients in age, course of disease, had no significant difference in the proportion of menopause patients (P0.05), the basic situation of the patients was consistent and comparable. (2) baseline comparison: before treatment, the two groups were scored in the KI score, the score of vasomotion symptoms, the score of mental and neurologic symptoms, and the MENQOL scale evaluation. There was no significant difference in the level of E2 and FSH (P0.05). (3) compared with the two groups, after the treatment, the follow-up was 3 months after the end of the treatment. The scores of vasomotion symptoms, the scores of mental and neurologic symptoms, and the MENQOL scale score were statistically significant (P0.05). In the serum E2 level, the two groups were compared with the treatment before treatment. The difference was statistically significant (P0.05), but the difference was not statistically significant (P0.05) after 3 months of treatment. At the level of serum FSH, there was no significant difference between the two groups after the treatment and 3 months after the end of the treatment (P0.05). (4) the two groups were treated after the treatment, and after the end of the treatment, the follow-up was in the KI score, and the symptoms of vasomotion were accumulated. The scores of mental and neurologic symptoms, MENQOL scale score, and serum E2 and FSH levels were not statistically significant (P0.05), and there was no significant difference in the overall efficiency of the two groups (P0.05); the two groups were in safety, and the difference in the acceptance of the patients was statistically significant (P0.05). Conclusion the percutaneous point electrical stimulation and electroacupuncture can improve the perimenopausal syndrome The clinical symptoms of patients with perimenopausal syndrome were improved, and the clinical symptoms of perimenopausal syndrome were improved by percutaneous acupoint electrical stimulation, and the quality of life was not significantly different from that in the electroacupuncture group, and the long-term effect was equal. The percutaneous acupoint electrical stimulation and electroacupuncture could improve perimenopausal syndrome. The E2 level, but the long-term effect is not good, the FSH level of the patients with perimenopausal syndrome is not significantly improved by the percutaneous point electrical stimulation and Electroacupuncture; the safety of the percutaneous acupoint electrical stimulation is better than the electroacupuncture treatment.

【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R246.3

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