金玉教授学术思想继承和临床经验的整理及蒙药苏格木勒-7味丸为主治疗赫依布日勒得森病的临床研究

发布时间：2018-04-22 05:21

本文选题：金玉教授 + 学术思想　；参考：《北京中医药大学》2016年博士论文

【摘要】：目的：1.收集、整理、总结、继承发扬金玉教授的学术思想特点及临床经验和技术专长。2.通过以苏格木勒-7味丸为主要方药,评价其治疗“赫依布日勒得森病”的疗效及安全性,进一步证明蒙药治疗“赫依布日勒得森病”的临床疗效,提高“赫依布日勒得森病”的蒙医药诊治及临床治疗知识,用科学的方法证明其疗效,为临床用药提供可靠的科学依据。方法：1.根据跟师笔记及典型医案、老师的专著、科研成果等系统回顾导师的学术思想渊源,充分掌握指导老师的临床经验、诊病特点、用药经验等,全面收集、整理、继承金玉教授的学术思想及临床经验。(1)收集、整理指导老师的学术思想如下：①治疗“布日勒德森病”要以“血以调为补得”,以“调气血,热寒平衡交替施治”理念：②注重赫依其苏,强调平衡及滋补：③改善胃、脾、心、肝、肾的功能,达到平衡子宫及卵巢的功能；④注重蒙医的整体观思想及治疗妇科病时与妇女特性相结合为主：⑤强调改善肾脏功能,增加精华治疗疾病的目的：⑥注重胃及脾的功能：⑦根据症状引导治疗：⑧临床治疗中注重灵活应用药物：⑨强调骨骼损伤时分期辩证用药。(2)收集、整理指导老师的临床经验如下：本研究中主要整理了指导老师治疗原发性痛经、子宫出血、不孕症、子宫肌瘤、外阴白斑、“赫依布日勒得森病”、乳腺的齐苏布日勒德森病等治疗妇科疾病的临床经验。整理了治疗关节黄水病、心律不齐、胃病、肺赫依为主的咳嗽病、遗精病、齐苏希日型头痛病等其他系统疾病的临床经验。2.在本研究中经过整理研究指导老师的学术思想和临床经验,并结合本人的临床专业,观察以苏格木勒-7味丸为主要方药治疗“赫依布日勒得森病”的临床疗效及安全性。3.选取符合纳入标准的80例“巴达干赫依型”赫依布日勒得森病患者,随机分为治疗组及对照组,每组40例,治疗组早：苏格木勒-7味丸15粒饭前口服,中午：通拉嘎-5味丸15粒饭后口服,晚：苏格木勒-7味丸15粒以阿嘎如-35味散5克送服。对照组：中药舒更片,3片日三次饭后温水送服。总疗程为8周,观察指标为患者一般信息、生命体征；安全指标有肝肾功能、血常规；疗效性指标为各种症状变化及女性激素E2(雌二醇),FSH(卵泡刺激素),LH(黄体生成激素)的变化等。各指标在治疗前后检查一次,并进行组内治疗前后及组间对比分析。结果：1.收集、整理指导老师的学术思想如下：治疗“布日勒德森病”要以“血以调为补得”,以“调气血,热寒平衡交替施治”理念：注重赫依其苏,强调平衡及滋补；改善胃、脾、心、肝、肾的功能,达到平衡子宫及卵巢的功能；注.重蒙医的整体观思想及治疗妇科病时与妇女特性相结合为主：强调改善肾脏功能,增加精华治疗疾病的目的：注重胃及脾的功能：根据症状引导治疗：临床治疗中注重灵活应用药物：强调骨骼损伤时分期辩证用药。2.收集、整理指导老师的临床经验如下：本研究中主要整理了指导老师治疗原发性痛经、子宫出血、不孕症、子宫肌瘤、外阴白斑、“赫依布日勒得森病”、乳腺的齐苏布日勒德森病等治疗妇科疾病的临床经验。整理了治疗关节黄水病、心律不齐、胃病、肺赫依为主的咳嗽病、遗精病、齐苏希日型头痛病等其他系统疾病的临床经验。3.以苏格木勒-7味丸为主的蒙药治疗“赫依布日勒得森病”的疗效平价显示：治疗组总有效率为94.59%,对照组为84.21%,两组间有显著性差异(P0.05),治疗组优于对照组；两组症状的总数对比后,治疗前两组无显著性差异(P0.05),治疗后治疗组改善症状方面优于对照组；各症状两组除了白带增多外其他症状治疗前后有显著性差异(P0.05)；两组E2、FSH、LH激素水平治疗前对比无显著性差异(P0.05),治疗后两组的E2均升高,FSH、LH水平均下降,治疗组作用优于对照组(P0.05)；血常规,肝肾功能等安全性指标检查结果显示：治疗前后组内对比和组间对照无显著性差异(P0.05)。结论：1.传承名老蒙医学术思想是发展蒙医药的重要途径。收集、整理并总结金玉教授的学术思想和临床经验、用药手法,对蒙医妇科学术的发展具有重要的意义,并对妇科疑难病的诊治将起到一定的推动作用。2.指导老师对“赫依布日勒得森病”的诊治方面具有独特的见解和临床经验,并疗效可靠。3.本研究结果显示：蒙药苏格木勒-7味丸为主要方药的蒙药治疗“赫依布日勒得森病”的疗效确切,且在改善各种症状优于对照组(舒更片组)；蒙药组对E2、FSH、LH激素水平改善优于对照组。4.以蒙药苏格木勒-7味丸为主要方药的蒙药治疗“赫依布日勒得森病”方法安全且无毒副作用,临床应推广应用。创新点：1.首次全面系统整理总结了金玉教授的学术思想及临床经验,尤其总结了辩证诊治妇科病的独到见解及独特的诊疗特色,对蒙医妇科学术发展具有重要意义,同时对蒙医妇科疑难疾病的治疗将起到一定的推动作用。2.根据古籍文献记载及指导老师对本病的蒙医药诊治的见解和观点及临床经验,创新性提出了自己的观点。①“赫依布日勒得森病”病因虽然是“巴达干赫依”但是赫依增多,齐苏滋补缺乏,赫依齐苏失调也是主要的病因。②方面食用生冷食物及受寒冷、淋雨等使体内“赫依、希日、巴达干”失调,引起“赫依布日勒得森病”。病根随血流到达各脏腑形成全身性疾病。另一方面社会及家庭的因素使思想压力过重,使病情加重。③随着人的年龄增长各种脏腑功能减弱,赫依齐苏滋补缺乏引起,子宫及卵巢的功能衰退,赫依齐苏失调引起发病。④治疗：降巴达干赫依,调节赫依齐苏失调,改善肾功能,根据症状辩证施治为原则,治疗药物的选择上把晚上口服的苏格木勒-7味丸以调节依齐苏失调,改善睡眠的阿嘎如-35味散为引子,为达到彻底治疗本病的基础上确立了该项研究,用科学的方法证明了其疗效。3.首次科学研究证明了蒙药苏格木勒-7味丸为主要方药,治疗“赫依布日勒得森病”的临床疗效。
[Abstract]:Objective: 1. collecting, sorting, summarizing, inheriting the academic thought characteristics, clinical experience and technical expertise of Professor Jinyu,.2. through using Suge Mu Le -7 pill as the main prescription to evaluate the curative effect and safety of the treatment of "heyllolde disease", and further prove the clinical effect of the Mongolian medicine for the treatment of "heyllolde disease". The knowledge of medical treatment and clinical treatment of "Helby Le de Sen's disease" has been proved by scientific methods to provide a reliable scientific basis for clinical medication. Methods: 1. according to the notes of the teachers and typical medical cases, teachers' monographs, scientific research results and so on, the academic thought origin of tutors is reviewed, and the instructor's clinical practice is fully mastered. Experience, diagnosis characteristics, use of drug experience and so on, comprehensive collection, sorting, and inheriting the academic thought and clinical experience of Professor Jinyu. (1) collect and organize the teacher's academic ideas as follows: (1) to treat "brierson disease" with "blood to be mended", "Qi and blood, heat and cold balance alternately governing" concept: (2) pay attention to Heyi Su, strong Balance and nourish: improve the function of the stomach, spleen, heart, liver and kidney to balance the function of the uterus and the ovary; (4) pay attention to the overall concept of the Mongolian medicine and the combination of the women's characteristics when treating gynecologic diseases: 5. Emphasize the improvement of the function of the kidney and the order of the essence to treat the disease: (6) pay attention to the function of the stomach and the spleen: 7 according to the symptoms. The clinical experience of the teacher is summarized as follows: (2) the clinical experience of the teacher is collated and arranged as follows: This study mainly arranges the instructor to treat primary dysmenorrhea, uterine bleeding, infertility, uterine myoma, vulvar leukoplakia, "leiblaadson disease", mammary gland The clinical experience in the treatment of gynecologic diseases, such as subeb and rerederson's disease, and the clinical experience in the treatment of other systemic diseases such as yellow water disease, arrhythmia, gastric disease, lung HIRI based cough, eachnoid disease, Qi suhi type headache, and other systemic diseases.2. were collated and studied to guide the academic thought and clinical experience of the teacher in this study. According to my clinical specialty, the clinical efficacy and safety of the sugE Koller -7 pill as the main prescription for the treatment of "herb's disease" was observed and the.3. was selected in 80 cases of "Bada kouyi type" patients, which were randomly divided into the treatment group and the treatment group, 40 cases in each group, and the treatment group early: sug Mu Le -7 Oral pill 15 tablets before the meal oral, noon: Tong La GA -5 pill after 15 pills orally, late: sug Mu Le -7 pill 15 pills with a qua like -35 powder 5 grams of clothing. Control group: Chinese medicine Shu more tablets, 3 days after the three meal warm water delivery. The total course of treatment is 8 weeks, the observation index is the patient general information, life signs; safety indicators have liver and kidney function, blood routine; The curative effects were the changes of various symptoms and the changes of female hormone E2 (estradiol), FSH (follicle stimulating hormone), and the changes of LH (luteinizing hormone). Each index was examined once before and after treatment, and before and after treatment in the group, and before and after the comparison and analysis. Results: 1., the academic thoughts of the teacher were collected as follows: the treatment of "buerlerderson's disease" We should take "blood to adjust" to "regulate qi and blood, heat and cold balance alternately" concept: pay attention to h Yi Su, emphasize balance and nourishment, improve the function of stomach, spleen, heart, liver, kidney, to balance the function of the uterus and the ovary; note. The idea of the overall view of the heavy Mongolian medicine and the combination of the treatment and treatment of gynecopathy with the women's characteristics: emphasize the improvement The function of the kidney is to increase the essence of the treatment of the disease: pay attention to the function of the stomach and spleen: according to the symptom guided therapy: pay attention to the flexible application of drugs in the clinical treatment: emphasize the collection of.2. and the clinical experience of the teacher as follows: the master should arrange the instructor to treat the primary dysmenorrhea in this study. Clinical experience in the treatment of gynecologic diseases, such as uterine bleeding, infertility, uterine leiomyoma, leukoplakia, "hiriblerderson's disease", sircilson's disease in the breast, and other clinical experiences in the treatment of gynecologic diseases. The therapeutic parity of.3. with sugolen -7 pill in the treatment of "herb's disease" showed that the total effective rate of the treatment group was 94.59%, the control group was 84.21%, the two groups had significant difference (P0.05), and the treatment group was superior to the control group. After the total of the two groups of symptoms, there was no significant difference between the two groups (P0.05) before treatment and treatment after treatment. The symptoms in the treatment group were better than those in the control group; there were significant differences between the two groups before and after the treatment of other symptoms (P0.05). There was no significant difference in the levels of E2, FSH, and LH in the two groups before treatment (P0.05). After treatment, the E2 of two groups increased, the average of FSH, LH water decreased, and the effect of the treatment group was better than the control group (P0.05); blood routine routine was better than the control group. The results of liver and kidney function and other safety indicators showed that there was no significant difference between the groups before and after treatment and between the groups (P0.05). Conclusion: 1. the thought of inheriting the name and old Mongolian medicine is an important way to develop Mongolian medicine. The exhibition has important significance, and it will play a certain role in the diagnosis and treatment of gynecologic difficult diseases..2. instructor has unique views and clinical experience on the diagnosis and treatment of "hiturdidison disease", and the result is reliable, and the results of.3. study show that Mongolian medicine sug Mu Le -7 pill is the main prescription for the treatment of "heria day". The curative effect of lolson's disease is better than that of the control group (Shu Keng tablet group); the improvement of E2, FSH, LH hormone in the Mongolian medicine group is better than that of the control group.4. with the Mongolian medicine sugolen -7 pill as the main prescription for the treatment of "herb's disease" method and non toxic side effect, and the clinical application should be applied. Innovation point: 1 For the first time, the academic thought and clinical experience of Professor Jinyu were summarized and summarized in a comprehensive system, and the unique views and unique diagnosis and treatment features of the dialectical diagnosis and treatment of gynecologic diseases were summarized, which was of great significance to the academic development of the gynecologic diseases in Mongolian medicine. At the same time, the treatment of the difficult diseases of the Mongolian medicine and gynecologic diseases would be promoted by.2. according to the literature of the ancient books. And instructor's views and clinical experience on the medical and medical treatment of this disease, and the clinical experience, and the innovative point of view. (1) the cause of "hitchisaisson disease" is "Bada dry hitai" but the increase of hitaigan, the deficiency of Qi Su, the disorder of heria Qi Su is also the main cause. On the other hand, the social and family factors make the ideological pressure too heavy and aggravate the condition. The function decline of the uterus and ovary, the disorder caused by the heritii su. 4 treatment: lowering the badha dry hiyi, regulating the disorder of heritii, improving the function of the kidney, improving the function of the kidney, according to the dialectical treatment of symptoms. In order to achieve a thorough treatment of the disease, this study was established, and a scientific method was used to prove that the first scientific study of its curative effect.3. proved that the Mongolian medicine Suge Mu Le -7 pill is the main prescription for the treatment of "herb's disease".

【学位授予单位】：北京中医药大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R29

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