“黄白颗粒”治疗婴幼儿轮状病毒肠炎的临床研究

发布时间：2018-04-22 13:31

本文选题：黄白颗粒 + 轮状病毒　；参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:以思密达联合消旋卡多曲治疗为对照,观察黄白颗粒治疗婴幼儿轮状病毒肠炎湿热证的疗效及其安全性。方法:采用随机平行对照(阳性药物对照)设计的临床研究方法,将符合纳入标准的60个病例按照随机原则分为治疗组和对照组各30例。两组均根据病情需要予补液治疗,治疗组予口服黄白颗粒,对照组予思密达、消旋卡多曲,疗程5天。比较治疗后两组患儿的大便次数、大便性状、发热、呕吐等方面的情况及用药安全性。结果:大便次数正常的患儿,治疗组有23例(76.67%),对照组有16例(53.33%);大便性状正常的患儿,治疗组有23例(76.67%),对照组有15例(50.00%);两组数据对比,P值均0.05,差异均有统计学意义;两组患儿大便次数和性状、体温、呕吐、腹痛、脱水等主要临床症状恢复的时间相比较,治疗组效果更好;两组总有效率分别为96.67%、93.33%,痊愈率76.67%、53.33%,统计后P0.05,差异有统计学意义,黄白颗粒疗效更佳;治疗组轮状病毒转阴率高于对照组,且整个治疗过程中未出现任何毒副反应。结论:黄白颗粒对于婴幼儿轮状病毒肠炎,在止泻、退热、止呕方面效果显著,可缩短病程,其疗效明显优于思密达联合消旋卡多曲组。证明黄白颗粒治疗婴幼儿轮状病毒肠炎之湿热证是安全且有效的。
[Abstract]:Objective: to observe the efficacy and safety of Huangbai granule in treating infant rotavirus enteritis with damp-heat syndrome. Methods: 60 patients who met the inclusion criteria were randomly divided into treatment group (n = 30) and control group (n = 30). Both groups were treated with rehydration according to their condition. The treatment group was treated with Huangbai granule and the control group was treated with smecta and racemic cardotrix for 5 days. The defecation times, defecation traits, fever, vomiting and drug safety were compared between the two groups. Results: there were 23 patients with normal defecation in the treatment group and 16 patients in the control group with 53.33jiao, 23 patients in the treatment group and 15 patients in the control group with normal defecation traits, and there were significant differences between the two groups (P < 0.05). In comparison with the recovery time of the main clinical symptoms such as body temperature, vomiting, abdominal pain and dehydration, the total effective rate of the two groups was 96.677,93.33 and the cure rate was 76.677.67 and 53.33.The difference was statistically significant (P 0.05). The rotavirus negative rate in the treatment group was higher than that in the control group, and no side effects were found in the whole treatment process. Conclusion: the effect of Huangbai granule on infantile rotavirus enteritis is significant in reducing diarrhea, fever and vomiting, and can shorten the course of disease. The curative effect of Huangbai granule is better than that of smecta combined with racemic cardotrix group. It is proved that Huangbai granule is safe and effective in treating infant rotavirus enteritis with damp-heat syndrome.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R272

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