补肾宁心汤治疗心肾不交型卵巢早衰的临床观察

发布时间：2018-04-23 11:50

本文选题：补肾宁心汤 + 心肾不交　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察补肾宁心汤治疗心肾不交型卵巢早衰的临床疗效,分析其对患者卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、子宫内膜厚度及子宫体积的影响,探讨其对性腺轴的影响及影响机制。方法:将64例符合病例选择标准的心肾不交型卵巢早衰患者随机分为试验组(口服补肾宁心汤)和对照组(口服坤泰胶囊)各32例。观察两组患者治疗前后中医证候的改变情况;治疗前后两组患者FSH、LH、E2、子宫内膜厚度及子宫体积的变化情况。结果:1.疾病疗效方面,试验组、对照组总有效率分别为81.25%、43.75%,两组比较差异有统计学意义(P0.05)。2.中医证候疗效方面,试验组、对照组总有效率分别为87.5%、56.25%,两组比较差异有统计学意义(P0.05);中医证候积分和方面,两组患者治疗后积分和较治疗前均降低,治疗后试验组积分和低于对照组,差异有统计学意义(P0.05)。3.单项症状疗效方面,试验组各项中医症状改善率均高于对照组,差异有统计学意义(P0.05)。4.月经复潮方面,试验组、对照组复潮率分别为87.5%、59.38%,两组复潮率比较差异有统计学意义(P0.05)。5.辅助检查方面,试验组治疗后FSH、LH降低,E2升高,与治疗前比较差异有统计学意义(P0.05),治疗后组间比较差异有统计学意义(P0.05);试验组治疗后子宫内膜增厚,子宫体积增大,与治疗前比较差异有统计学意义(P0.05),治疗后组间比较差异有统计学意义(P0.05)。结论:口服补肾宁心汤治疗心肾不交型卵巢早衰疗效确切,能使患者复潮,中医证候疗效明显,能够改善卵巢功能。试验组与对照组比较,综合疗效、中医证候疗效及卵巢、子宫功能恢复都有明显优势。
[Abstract]:Objective: to observe the clinical effect of Bushen Ningxin decoction (BNXD) in treating premature ovarian failure with heart and kidney disjoint type, and to analyze its effect on follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E _ 2), endometrial thickness and uterine volume. To investigate the effect and mechanism of gonadal axis. Methods: 64 cases of premature ovarian failure with heart and kidney disjoint type were randomly divided into two groups: experimental group (32 cases) and control group (32 cases). The changes of TCM syndromes before and after treatment and the changes of FSHLHN E2 endometrial thickness and uterine volume before and after treatment were observed. The result is 1: 1. The total effective rate of the treatment group and the control group were 81.25 and 43.75, respectively. The difference between the two groups was statistically significant (P 0.05). In terms of the curative effect of TCM syndromes, the total effective rates of the experimental group and the control group were 87.5% and 56.25, respectively, and the difference between the two groups was statistically significant (P 0.05), and the scores and aspects of TCM syndromes in the two groups were decreased after treatment and compared with those before treatment. After treatment, the score of the experimental group was lower than that of the control group, and the difference was statistically significant (P 0.05). The improvement rate of each TCM symptom in the test group was higher than that in the control group, and the difference was statistically significant. In terms of menstrual resuscitation, the rates of resuscitation in the experimental group and the control group were 87.5% and 59.38, respectively, and the difference between the two groups was statistically significant (P 0.05). As for adjuvant examination, the level of FSH LH decreased after treatment in the trial group, which was significantly higher than that before treatment (P 0.05), and there was significant difference between the two groups after treatment (P 0.05), and the endometrium thickened and the uterus volume increased after treatment in the trial group. There was significant difference between the two groups before and after treatment (P 0.05). Conclusion: Bushen Ningxin decoction is effective in treating premature ovarian failure of heart and kidney disjoint type. Compared with the control group, the experimental group has obvious advantages in comprehensive curative effect, TCM syndrome curative effect, ovary and uterine function recovery.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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