中药超微颗粒化瘀止痛方外敷治疗腹部中度癌痛的临床研究

发布时间：2018-04-23 14:23

本文选题：中药超微颗粒化瘀止痛方 + 癌性疼痛　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的:观察中药超微颗粒化瘀止痛方外敷治疗腹部中度癌性疼痛的疗效以及其对患者NRS评分、KPS评分的影响、药物的不良反应及安全性,探索中药超微颗粒的新用法,为中药超微颗粒化瘀止痛方治疗癌性疼痛的临床应用提供理论依据。方法:将患者分为观察组与对照组,各30例,观察组给予中药超微颗粒化瘀止痛方外敷,对照组予以奇正消痛贴外用,疗程均为1周。治疗结束后,比较两组患者的NRS评分、疼痛缓解率、止痛起效时间、最佳止痛时间、镇痛持续时间、KPS评分,观察药物的安全性及不良反应。结果:1.NRS评分:治疗后两组NRS评分均较治疗前明显降低,具有较好的止痛效果,在降低NRS评分方面两组疗效相当。2.止痛有效率:观察组总有效率86.7%;对照组总有效率83.4%。经检验,P0.05,两组止痛有效率相当。3.止痛起效时间、最佳止痛时间、镇痛持续时间:观察组与对照组止痛起效时间相当,观察组的最佳止痛时间、镇痛持续时间均长于对照组。4.KPS评分:治疗后两组KPS评分均较治疗前明显升高,两组治疗均能提高患者的KPS评分。两组在提高KPS评分方面水平相当。5.不良反应:治疗后观察组两组患者皮肤瘙痒、皮疹、敷药脱落发生率,经统计学分析,P0.05,差异无统计学意义。6.安全性观察:治疗后检查心电图、大小便常规,抽血查血常规、肝肾功能、凝血功能等结果均未发现明显异常。结论:1.中药超微颗粒化瘀止痛方能降低患者NRS评分,对腹部中度癌性疼痛有较好的疗效,止痛有效率与奇正消痛贴相当;2.中药超微颗粒化瘀止痛方止痛起效时间与奇正消痛贴相当;最佳止痛时间、镇痛持续时间均长于奇正消痛贴。3.中药超微颗粒化瘀止痛方在有效治疗癌痛的同时,可提高患者生活质量,且无明显不良反应,安全、无毒副作用。对于腹部中度癌痛的病人值得推广。
[Abstract]:Objective: to observe the curative effect of traditional Chinese medicine ultrafine granule Huayu Zhitong prescription on abdominal moderate cancer pain and its effect on NRS score of patients, adverse drug reaction and safety, and to explore the new use of ultrafine granules of traditional Chinese medicine. To provide theoretical basis for the clinical application of traditional Chinese medicine ultrafine granule Huayu Zhitong prescription in the treatment of cancer pain. Methods: the patients were divided into the observation group (n = 30) and the control group (n = 30). The observation group was treated with traditional Chinese medicine ultrafine granule Huayu Zhitong prescription and the control group was treated with Qizhengxiaotong paste for one week. After the treatment, the NRS score, pain relief rate, analgesic onset time, optimal analgesic time and analgesic duration were compared between the two groups, and the safety and adverse reactions of the drugs were observed. Results 1.NRS score: after treatment, the NRS scores of the two groups were significantly lower than those before treatment, and had a better analgesic effect. The two groups had the same curative effect in reducing the NRS score. 2. The total effective rate of pain relief was 86.7 in the observation group and 83.4 in the control group. The effective rate of pain relief in the two groups was equivalent to 3. 3. The time of analgesic effect, the best time of analgesic effect, the duration of analgesia: the time of analgesic effect in the observation group was the same as that in the control group, and the best time of pain relief in the observation group, The duration of analgesia was longer than that of the control group. 4. KPS scores: after treatment, the KPS scores of the two groups were significantly higher than those before treatment, and both groups could improve the KPS score of the patients. The two groups were equal in improving KPS scores. 5. 5. Adverse reactions: after treatment, the incidence of pruritus, rashes, and shedding of drugs in the observation group was not statistically significant (P 0.05), and there was no significant difference between the two groups. Safety observation: the results of electrocardiogram examination, routine examination of urine and urine, blood routine examination, liver and kidney function, coagulation function, etc. Conclusion 1. The traditional Chinese medicine ultrafine granule Huayu Zhitong prescription can reduce the patient's NRS score, has the better curative effect to the abdominal moderate cancerous pain, the analgesic effective rate is equivalent to the Qizhengxiaotong paste 2. The time of analgesic effect of traditional Chinese medicine ultrafine granule Huayu Zhitong recipe is the same as that of Qizheng Xiaotong paste, and the best analgesic time and analgesic duration are longer than that of Qizheng Xiaotong paste. 3. The traditional Chinese medicine ultrafine granule Huayu Zhitong prescription can effectively treat cancer pain, at the same time, can improve the quality of life of patients, and no obvious adverse reactions, safety, no toxic side effects. For patients with moderate abdominal cancer pain, it is worth promoting.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273

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