滋阴补肾法对肾病综合征患者糖皮质激素性骨质疏松症的临床研究

发布时间：2018-04-24 14:44

本文选题：滋阴补肾 + 糖皮质激素性骨质疏松症　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察滋阴补肾法防治肾病综合征患者糖皮质激素性骨质疏松症(glucocorticoid-induced osteoporosis,GIOP)的临床疗效,并探讨左归丸在防治本病方面的作用机制。方法:将64例符合纳入标准的GIOP患者,依照随机数列表分为治疗组和对照组,组内病例数均为32例,均按照西医基础治疗方案治疗,对照组加服碳酸钙D3(1次1片,1日2次,三餐后嚼服),治疗组加用碳酸钙D3及左归丸加减(一次200ml,每日两次)治疗,疗程为6个月。分别观察各组在治疗前后临床症状体征,并检测各项化验室指标以及骨密度的变化。6个月研究观察结束,统计分析两组治疗前后各项化验指标及症状积分的变化。结果:研究初期两组各有32例患者,研究结束有60例患者完成为期6个月观察研究,各出现两例脱落病例。两组在患者个人基本信息方面的差别不存在明显差异性;研究结束时治疗组肾病综合征GIOP的总有效率(93.3%)明显超过对照组(83.3%),具有统计学意义(P0.05);两组患者在研究结束后于各项相关生化指标及骨密度等方面比较,均较前改善(P0.05),两组患者治疗后相比,治疗组对于血钙、甲状旁腺激素、骨密度等的改善作用表现超过对照组(P0.05)。两组患者在中医临床症状体征方面,治疗组对GIOP患者改善情况明显好于对照组(P0.05)。结论:左归丸配合基础治疗方案对于肾病综合征GIOP患者临床症状、体征有明显改善作用,同时对于改善患者各项相关生化指标及骨密度都有着明显影响,从而对肾病综合征GIOP患者预后产生积极影响。
[Abstract]:Objective: to observe the clinical effect of nourishing yin and tonifying kidney in prevention and treatment of glucocorticoid-induced osteoporosisGIOP (GIOP) in patients with nephrotic syndrome and to explore the mechanism of Zuogui Pill in preventing and treating this disease. Methods: 64 patients with GIOP were divided into treatment group and control group according to the random number list. 32 cases in the group were treated in accordance with the basic treatment plan of western medicine, while the control group was treated with calcium carbonate D _ 3O _ 3 once a time, twice a day. The treatment group was treated with calcium carbonate D3 and Zuo Gui Wan (200ml, twice a day) for 6 months. The clinical symptoms and signs were observed before and after treatment, and the changes of laboratory indexes and bone mineral density were detected. After 6 months' observation, the changes of the laboratory indexes and symptom scores before and after treatment were statistically analyzed. Results: at the beginning of the study, there were 32 patients in each group, and 60 patients completed the study for 6 months. There was no significant difference between the two groups in the basic information of patients. At the end of the study, the total effective rate of GIOP in the treatment group was significantly higher than that in the control group (83.3%, P 0.05). After treatment, the improvement of serum calcium, parathyroid hormone and bone mineral density in the treatment group was higher than that in the control group (P 0.05). In terms of clinical symptoms and signs of TCM, the improvement of GIOP in the treatment group was better than that in the control group (P 0.05). Conclusion: Zuo Gui Pill combined with basic treatment can significantly improve the clinical symptoms and signs of patients with nephrotic syndrome (GIOP), at the same time, it has a significant effect on the improvement of the related biochemical indexes and bone mineral density in patients with nephrotic syndrome. Therefore, the prognosis of patients with nephrotic syndrome (GIOP) was positively affected.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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