舒肝颗粒治疗糖尿病周围神经病变伴轻中度抑郁症的临床观察

发布时间：2018-04-25 04:20

本文选题：舒肝颗粒 + 糖尿病周围神经病变　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:通过观察舒肝颗粒治疗糖尿病周围神经病变伴轻中度抑郁症的临床疗效,探讨糖尿病周围神经病变的治疗新方法,以提高糖尿病患者的生活质量,减轻患者的心理痛苦,降低本病的致残率。方法:将60例糖尿病周围神经病变伴轻中度抑郁症的患者随机分为治疗组和对照组,治疗组与对照组各30例。对照组在给予基础降糖治疗的情况下给予甲钴胺注射500ug肌肉注射QD。治疗组在对照组治疗的基础上加服舒肝颗粒,一次一袋,一日三次,开水冲服。疗程8周,观察中医症侯、血糖,糖化血红蛋白,神经传导速度,汉密尔顿(HAMD)抑郁量表测定的变化。安全性疗效观察血常规、尿常规、肝肾功等变化。结果:治疗组综合有效率为73.3%,对照组综合有效率为50%,治疗组优于对照组,P㩳0.05。治疗组中医症侯与对照组相比,有所改善,且P㩳0.05;治疗组血糖与对照组相比,有所改善,且P㩳0.05;治疗组神经传导速度与对照组相比,有所改善,且P㩳0.05;治疗组汉密尔顿(HAMD)抑郁量表得分较对照组明显改善,且P㩳0.05。安全性指标前后无明显变化,P0.05。说明舒肝颗粒可以理气疏肝,缓解患者抑郁状态,进而提高神经传导速度,且安全有效。结论:舒肝颗粒可明显改善糖尿病周围神经病变伴轻中度抑郁患者的临床症状、血糖,神经传导速度,汉密尔顿(HAMD)抑郁量表得分等各项指标,临床疗效显著,具有良好的临床推广意义。
[Abstract]:Objective: to observe the clinical efficacy of Shugan granule in the treatment of diabetic peripheral neuropathy with mild and moderate depression, and to explore a new method for the treatment of diabetic peripheral neuropathy, so as to improve the quality of life and alleviate the psychological pain of diabetic patients. Reduce the disability rate of the disease. Methods: 60 cases of diabetic peripheral neuropathy with mild and moderate depression were randomly divided into treatment group and control group, 30 cases in treatment group and 30 cases in control group. The control group was treated with basic hypoglycemic therapy. The patients in the control group were injected with 500ug intramuscularly. The treatment group in the control group on the basis of treatment plus Shugan granule, one bag, three times a day, boiled water. For 8 weeks, the changes of TCM symptoms, blood glucose, glycosylated hemoglobin, nerve conduction velocity and Hamd depression scale were observed. The changes of blood routine, urine routine, liver and kidney function were observed. Results: the comprehensive effective rate was 73.3 in the treatment group and 50 in the control group, which was better than that in the control group. Compared with the control group, the TCM symptoms in the treatment group were improved, and P0. 05; the blood sugar in the treatment group was improved compared with the control group, and P0. 05; the nerve conduction velocity in the treatment group was improved compared with that in the control group. The score of Hamd in the treatment group was significantly improved than that in the control group, and the score of the depression scale in the treatment group was better than that in the control group (P < 0.05). There was no significant change in the safety index before and after P0.05. It shows that Shugan granule can regulate qi and soothe liver, relieve depression and improve nerve conduction velocity, and it is safe and effective. Conclusion: Shugan granule can significantly improve the clinical symptoms, blood glucose, nerve conduction velocity, and the score of Hamilton's HAMD-depression scale in patients with diabetic peripheral neuropathy with mild and moderate depression. It has good clinical significance.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.7

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