肝脾通调治疗腹泻型肠易激综合征用药规律分析

发布时间：2018-04-25 15:21

本文选题：腹泻型肠易激综合征 + 用药规律分析　；参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:通过对白光教授所用的中药进行用药频率、相关性分析等多方面的统计分析,探索总结其治疗IBS-D的核心药物、药性、归经、药类、药对等,为以后IBS-D的治疗提供理论和临床依据、为专家经验总结提供新的思路,也为中医学术经验整理和继承提供一定的方法。材料与方法:收集来辽宁中医药大学附属医院脾胃病科,2014年5月23日至2015年8月20日,由白光教授诊治的患者病例,根据纳入和排除标准进行筛查所得的病例。通过导师门诊治过的患者门诊诊疗记录进行拍照,采集门诊信息。运用Excel表格录入使在门诊诊疗过程中日期、性别、年龄、方药等信息,统计用药频次,药物的性味归经和分类并转换为可分析的数据,通过手工分析和统计学软件(SPSS22.0)共同进行数据分析,互相参照得出结论。结果:1.从纳入病例中共总结出138味中药,频率大于25%的有22味,前5味依次为白术、白芍、茯苓、黄连、甘草。2.治疗所用3404次药中所用药味:苦、甘、辛用频数最多,淡、酸、涩用相对少,咸最少。3.药性分类:温性药最多,使用频数为1441次,其余依次为寒、平、凉、热。4.归经最多的是:脾经、胃经、肺经、肝经、心经;其次是:大肠经、肾经、胆经;最少的是:膀胱经、三焦经、小肠经、心包经。5.补虚药、清热药二者在其治疗中占主导地位。其次利水渗湿药、化湿药、理气药这五类药是治疗IBS-D的主要药物。6.将使用频次大于50次的22味药用SPSS22.0进行相关性分析,通过筛选,列出P0.01的50对药。结论:1.由治疗IBS-D药物分析可知,白师常用补虚药和清热药药治疗本病,佐以利湿、理气药,反映了IBS-D肝郁脾虚湿盛的病因病机特点以及补虚祛邪理气并用、肝脾通调的用药特点。2.白师治疗本病所选药物中,药物药性温性药最多,药味以苦、甘、辛药味药物为主,主归脾经、胃经、肺经、肝经。
[Abstract]:Objective: to explore and summarize the core drugs, drugs, meridians, drugs and drug equivalents in the treatment of IBS-D by statistical analysis of the frequency and correlation of the Chinese medicine used by Professor Bai Guang. To provide theoretical and clinical basis for the treatment of IBS-D in the future, to provide new ideas for expert experience summing up, and to provide certain methods for sorting out and inheriting academic experience of traditional Chinese medicine. Materials and methods: from May 23, 2014 to August 20, 2015, the Department of spleen and stomach Diseases, affiliated Hospital of Liaoning University of traditional Chinese Medicine, was selected according to the criteria of inclusion and exclusion. The information of outpatient service was collected by taking pictures through the records of outpatient diagnosis and treatment. The information of date, sex, age, prescription medicine and so on in the course of outpatient diagnosis and treatment were recorded by Excel table, the frequency of drug use was counted, the quality of drugs was classified and converted into analyzable data. Through manual analysis and statistical software SPSS 22.0, the data were analyzed, and the conclusion was drawn by cross-reference. The result is 1: 1. A total of 138 Chinese herbs were summarized from the cases, 22 of which were more than 25% frequency, the first 5 were Atractylodes macrocephala, Radix Paeoniae Alba, Poria cocos, Coptis chinensis, Glycyrrhiza uralensis. The drugs used in the treatment of 3404 times: bitter, sweet, symplectic use the most frequency, light, acid, astringent used relatively less, the least salty. 3. Drug classification: the most mild drugs, the frequency of use is 1441, the rest in turn is cold, flat, cool, hot. 4. The most common meridians were spleen, stomach, lung, liver, heart, followed by large intestine, kidney, gallbladder, bladder, small intestine and pericardium. Tonifying deficiency medicine and clearing away heat medicine play a leading role in their treatment. Secondly, the five kinds of drugs, I. e., promoting water and infiltrating dampness, dehumidifying and regulating qi, are the main drugs in the treatment of IBS-D. The correlation of 22 medicinal SPSS22.0 with frequency more than 50 times was analyzed and 50 pairs of drugs were listed by screening. Conclusion 1. From the analysis of the treatment of IBS-D drugs, it can be seen that the common medicine of tonifying deficiency and clearing heat is used in the treatment of this disease, with the combination of liver-qi and dampness, regulating qi, reflecting the characteristics of the etiology and pathogenesis of IBS-D, the combination of tonifying deficiency, dispelling evil and regulating qi, and the drug characteristics of regulating liver and spleen. Bai Shi selected drugs for the treatment of this disease, the most medicinal properties of warm drugs, drug taste to bitter, sweet, Xin medicine medicine, the main return to the spleen, stomach, lung, liver meridian.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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