喜情绪诱导对阈下抑郁人群负性认知调节的事件相关电位研究

发布时间：2018-04-25 15:26

本文选题：情志相胜 + 情绪诱导　；参考：《北京中医药大学》2017年硕士论文

【摘要】：背景:阈阂下抑郁(SD,Subthreshold Depression)是指存在抑郁状态表现,但尚未达到抑郁症临床诊断标准的一种亚健康状态。综合国内外现有研究,阈下抑郁的患病率约为19%,普遍存在于人群之中,并且有研究表示阈下抑郁人群发展为抑郁症甚至重症抑郁的风险高于普通人,但阈下抑郁人群的认知加工特点尚未达成统一认识。中医情志相胜理论能够从"治未病"角度出发,有效改善阈下抑郁患者的情绪状态,但其作用靶点和作用机制尚不明确。目的:探索情志相胜理论指导下喜情绪诱导对阈下抑郁人群的的作用靶点和作用机制。方法:本研究通过张贴海报招募被试,使用流调中心用抑郁自评量表和汉密尔顿抑郁量表(17项版)评估被试的情绪状态,以CES-D≥16且7≤HAMD-1717作为阈下抑郁被试辨别依据,使用随机数表法将招募来的被试分为阈下抑郁被试情绪诱导组、阈下抑郁被试对照组、正常被试对照组和正常被试情绪诱导组,分组情况对被试隐藏。以中医情志相胜理论为基础构建由电影片段和喜情绪相关回忆共同构成的喜情绪诱导方案,经初步验证后作为实验材料用于后续研究。本研究实验将行为学Oddball范式和事件相关电位技术相结合进行研究,阈下抑郁被试情绪诱导组和正常被试情绪诱导组接受喜情绪诱导后参与ERP实验,阈下抑郁被试对照组和正常对照组直接参与ERP实验,从实验伦理角度考虑,对照组ERP实验结束后接受喜情绪诱导。本研究使用依据视觉模拟评分法设计的《情绪状态调查问卷(2)》对情绪诱导的主观感受效果进行评价,使用正确率和反应时作为行为学指标,使用额区N2成分和顶区P3成分的波幅和潜伏期作为ERP指标,使用SPSS 22.0对资料进行统计分析。结果:①本研究纳入分析的样本量为阈下抑郁被试情绪诱导组14人,阈下抑郁被试对照组13人,正常被试对照组17人,正常被试诱导组16人,人口学信息分析显示,本研究中阈下抑郁人群和正常人群之间的人口学资料无统计学差异,阈下抑郁被试情绪诱导组、阈下抑郁被试对照组、正常被试对照组两两比较人口学资料也无统计学差异;②情绪诱导主观感受分析显示,"喜"情绪的人群和测量时间无交互作用(F=0.016,P0.05),测量时间有主效应(F=70.016,P0.05),人群有主效应(F=6.229,P0.05);"悲"情绪的人群和测量时间无交互作用(F=0.28,P0.05),测量时间没有主效应(F=2.57,P0.05),人群有主效应(F=9.57,P0.05);"焦虑"情绪的人群和测量时间无交互作用(F=1.480,P0.05),测量时间有主效应(F=1.8552,P0.05),人群有主效应(F=13.313,P0.05);③行为学数据分析显示,SD对照组被试在面对不同类型刺激时正确率有统计学差异(X2=8.227,P0.05),SD诱导组和正常对照组面对中性刺激时反应时有统计学差异(X2=-2.645,P0.05),其他组别及刺激类型分析无统计学差异;④ERP数据:通过绘制ERP脑电地形图发现,刺激呈现后200-300ms在右侧额区FZ、F2、FCZ、FC2通道附近有较强的负电位激活,300-430ms在左侧顶区CZ、C1、CPZ、CP1通道附近有较强的正电位激活;额区N2成分波幅分组和刺激类型之间不存在交互作用(F=12.617,P0.05),分组(F=8.282,P0.05)、刺激类型(F=1.294,P0.05)均有主效应;额区N2成分潜伏期分组和刺激类型间无交互作用(F=0.437,P0.05),分组(F=2.039,P0.05)无主效应,刺激类型(F=11.383,P0.05)有主效应;顶区P3成分波幅分组和刺激类型间有交互作用(F=4.922,P0.05),分组(F=1.788,P0.05)无主效应,刺激类型(F=3.282,P0.05)有主效应;顶区P3成分潜伏期分组和刺激类型间有交互作用(F=7.606,P0.05),分组无主效应(F=1.363,P0.05),刺激类型无主效应(F=1.873,P0.05)。结论:本研究构建的喜情绪诱导方案能够有效增强被试喜情绪感受,减弱焦虑情绪感受,改善阈下抑郁被试和正常被试的情绪状态。进一步分析发现喜情绪诱导调节阂下抑郁被试的认知机制为增强认知控制能力、增强对正性刺激的注意加工和对中性刺激的认知加工能力三个方面。而喜情绪诱导能够使阂下抑郁被试的部分认知加工和对正性刺激的注意加工恢复到正常水平,而认知控制能力和对中性刺激的认知加工能力甚至强于正常水平。
[Abstract]:Background: SD (Subthreshold Depression) refers to the presence of depression status, but it has not yet reached a subhealth state of clinical diagnostic criteria for depression. The prevalence of subliminal depression is about 19% in the current study at home and abroad. The prevalence of subliminal depression is common in the population, and there is a study that subliminal depression develops to depression. The risk of severe depression is higher than that of the ordinary people, but the cognitive processing characteristics of the subthreshold depression have not yet reached a unified understanding. The theory of traditional Chinese medicine can effectively improve the emotional state of subthreshold depressive patients from the perspective of "cure the disease", but the target and mechanism of its action are not yet clear. The target and mechanism of emotional induction on subthreshold depression. Methods: the subjects were recruited by poster, using the depression scale and the Hamilton Depression Scale (17 Editions) to evaluate the emotional state of the subjects, with CES-D more than 16 and 7 less HAMD-1717 as the basis for subthreshold depression, and the use of random numbers. The recruited subjects were divided into subthreshold depression subjects' emotional induction group, subthreshold depression group, normal subjects control group and normal subjects emotional induction group. The group situation was hidden in the subjects. In this study, the behavioral Oddball paradigm and event related potential technology were combined to study. The study was conducted in this study. The emotional induction group and the normal subjects in the normal subjects were induced to participate in the ERP experiment, and the subthreshold depression was directly involved in the E and the normal control group. RP experiment, from the experimental ethics point of view, the control group ERP after the end of the experiment to accept the joy of emotion induction. This study used the visual analogue scale design "emotional state questionnaire (2) > to evaluate the subjective feelings of emotional induction, use the correct rate and reaction as a behavioral index, the use of N2 components in the frontal area and the top area P3 The amplitude and incubation period were used as ERP index and SPSS 22 was used to analyze the data. Results: (1) the sample size was 14 in the subthreshold depression group, 13 in the subthreshold depression group, 17 in the normal control group and 16 in the normal trial group. The demographic information analysis showed that the threshold of this study was in this study. There was no statistical difference in the demographic data between the lower depression group and the normal population, the subthreshold depression was tested in the emotional induction group, the subthreshold depression was in the control group, and the 22 of the normal control group had no statistical difference, and the subjective feeling analysis showed that there was no interaction between the crowd of "happy" emotion and the time of measurement (F=0 .016, P0.05), the measurement time has the main effect (F=70.016, P0.05), the crowd has the main effect (F=6.229, P0.05); the people of "sad" mood and the measurement time have no interaction (F=0.28, P0.05), the measurement time has no main effect (F=2.57, P0.05), the crowd has the main effect (F=9.57, P0.05); "anxiety" mood people and measurement time have no interaction. There were main effects (F=1.8552, P0.05), and the population had main effect (F=13.313, P0.05). (3) behavioral data analysis showed that the correct rate of the SD control group was statistically different (X2=8.227, P0.05) in the face of different types of stimulation (X2=8.227, P0.05). The response of SD induction group and normal control group to neutral stimulus was statistically different (X2=-2.645, P0.05), and the other groups were different (X2=-2.645, P0.05). There was no statistical difference in the analysis of the type of stimulation; (4) ERP data: by plotting the ERP EEG map, it was found that 200-300ms was activated in the right frontal area FZ, F2, FCZ, FC2 channel, and 300-430ms was activated in the left top region CZ, C1, CPZ, and there was a strong positive potential activation near the CP1 channel. There is no interaction between types (F=12.617, P0.05), group (F=8.282, P0.05), and the type of stimulus (F=1.294, P0.05) has the main effect; there is no interaction (F=0.437, P0.05) between the subgroups of N2 components in the frontal region and the type of stimulus (F=0.437, P0.05), and the group (F=2.039, P0.05) has no main effect, and the stimulus type (F=11.383,) has the main effect. There were F=4.922 (P0.05), F=1.788 (P0.05) had no main effect, and the type of stimulus (F=3.282, P0.05) had the main effect; the subgroup of P3 components in the top region had interaction (F=7.606, P0.05), and the group had no main effect (F= 1.363, P0.05), and the type of stimulus had no main effect (F=1.873,). The emotional induction scheme can effectively enhance the emotional feeling of the subjects, weaken the anxiety emotion, improve the emotional state of the subthreshold depression subjects and the normal subjects. Further analysis shows that the cognitive mechanism of the depression under the mood induced regulation of depression is enhanced, the enhancement of the attention processing and the neutral stimulus to the positive stimulus is enhanced. There are three aspects of cognitive processing ability. Emotional induction can lead to partial cognitive processing and attention processing for positive stimuli to normal levels, while cognitive control and cognitive processing ability to neutral stimuli are even stronger than normal levels.

【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.7

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