八正散加减治疗湿热型细菌性阴道病疗效观察60例

发布时间：2018-04-26 18:44

本文选题：细菌性阴道病 + 湿热型　；参考：《广州中医药大学》2016年硕士论文

【摘要】：目的本研究观察清热利湿类中药方剂八正散加减治疗湿热型细菌性阴道病的疗效。并与单纯的甲硝唑对照组互相进行比较,观察研究患者不适情况是否有所好转或者是康复,通过比较治疗组与对照组患者阴瘁、分泌物增多治疗恢复情况,以及患者自身填写症状严重程度评估指标表,以评论八正散加减治疗湿热型细菌性阴道病的临床治疗效果。方法本研究是采取随机对照的临床试验,纳入符合诊断标准中医辨证符合湿热型,符合病例筛选的患者例。随机分组为中药治疗组与西药对照组,中药组以八正散为基础方加减；西药组予甲硝唑为对照组。两组皆治疗1周,停药1周之后复查,停药1月之后随访,观察患者治疗前后的临床症状体征与中医证候评分等改善情况。成果：完成的本研究病例共60例,治疗组(中药组)30例,对照组(西药组)30例,治疗前在性别,年龄,病程,两组间都没有统计学上的显着差异,两组的严重程度分级,分析出的结果在统计学上也没有显着的差异。即在受本治疗的患者在性别,年龄,病程与严重分级程度,接受不一样的治疗,成效的差异评估都不会照成干扰。中药治疗组与西药对照组治疗后在患者自觉临床症状与体征、阴道微生态内环境、及中医证候评分等方面皆有改善,疗程结束后,治疗组(中药组)和对照组(西药组)比较治疗前后的临床症状、观察评分表、体征等指标均有改善,与治疗前比较,均达统计学上显着差异(P0.05)即治疗组(中药法)与对照组(西药组)结果显示皆能显着改善临床的症状。治疗前后两组疗效评分表比较,治疗组(中药组)的改善优于对照组(P0.01)于治疗后,两组比较复发率有显著性差异(P0.05),治疗组(中药组)复发率显著低于对照组(西药组)。结论：八正散加减与甲硝唑治疗效果均能显著改善患者的临床症状与实验室指标。以中医系统辨证论治,给予湿热型细菌性阴道病患者服用八正散加减,可以显著改善临床症状,并且治疗效果及各项指标好转皆优于甲硝唑。
[Abstract]:Objective to observe the therapeutic effect of Bazheng Powder (Bazheng Powder), a traditional Chinese medicine prescription for clearing heat and dampness, in the treatment of damp-heat bacterial vaginosis. And compared with the simple metronidazole control group, we observed whether the discomfort of the patients was improved or recovered, and compared the patients of the treatment group with the control group. To evaluate the clinical efficacy of Bazheng Powder in the treatment of damp-heat bacterial vaginosis. Methods A randomized controlled clinical trial was conducted to include patients with dampness and heat syndrome differentiation and case screening according to the diagnostic criteria. They were randomly divided into Chinese medicine treatment group and western medicine control group, the traditional Chinese medicine group took Bazheng powder as the basic prescription and the western medicine group was given metronidazole as the control group. The patients in both groups were treated for 1 week, followed up after 1 week and followed up after one month. The improvement of clinical symptoms and signs and TCM syndromes before and after treatment were observed. Results: there were 60 cases in this study. There were 30 cases in the treatment group and 30 cases in the control group. There was no significant difference in sex age course of disease between the two groups before treatment. There was no statistically significant difference in the results of the analysis. That is, in the patients treated in gender, age, course of disease and severity of grade, receive different treatment, the effectiveness of the difference evaluation will not be interfered. After treatment, the Chinese medicine treatment group and the western medicine control group all improved the patients' conscious clinical symptoms and signs, vagina microenvironment, and TCM syndrome score. After the course of treatment, The treatment group (Chinese medicine group) and the control group (western medicine group) compared before and after the treatment of clinical symptoms, observation of scores, signs and other indicators improved, compared with before treatment, The results showed that the treatment group (Chinese medicine method) and the control group (western medicine group) could significantly improve the clinical symptoms. The improvement of treatment group (Chinese medicine group) was better than that of control group (P 0.01). After treatment, there was a significant difference in the recurrence rate between the two groups (P 0.05), and the recurrence rate of treatment group (traditional Chinese medicine group) was significantly lower than that of control group (western medicine group). Conclusion: both Bazheng Powder and Metronidazole can significantly improve the clinical symptoms and laboratory indexes. According to syndrome differentiation of traditional Chinese medicine, taking Bazheng Powder plus or minus in patients with bacterial vaginosis of damp-heat type, the clinical symptoms can be significantly improved, and the therapeutic effect and the improvement of each index are better than metronidazole.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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