基于文献计量学的高血压痰湿壅盛证患者血浆代谢组学研究

发布时间：2018-04-29 02:31

本文选题：高血压 + 痰湿壅盛证　；参考：《辽宁中医杂志》2017年07期

【摘要】：目的:探讨高血压痰湿壅盛证代谢组学产物的相互作用及生物学通路。方法:从中国知网、万方数据库、维普数据库、Embase、Pubmed数据库中检索高血压痰湿壅盛证患者血浆代谢组学研究。对纳入研究代谢产物进行汇总。信号通路分析采用KEGG,代谢产物分子注释、相关的酶或转运蛋白及其相关性质分析采用HMDB,代谢产物路径可视化采用metPA网络软件。结果:共有6篇文献纳入研究,15个代谢产物主要参与了28条代谢通路。通过通路拓扑分析选出了10条P值小于0.05的代谢通路作为高血压痰湿壅盛证的代谢通路,分别是:糖酵解和糖异生作用、D-谷氨酰胺和D-谷氨酸代谢、缬氨酸、亮氨酸和异亮氨酸的生物合成、磷酸戊糖途径、维生素B6代谢、丙酸代谢、缬氨酸、亮氨酸和异亮氨酸降解、半乳糖代谢、维生素C代谢、淀粉与蔗糖的代谢。结论:高血压痰湿壅盛证代谢组生物信息分析显示其病理机制涉及到糖类、脂肪、氨基酸、维生素等物质代谢及其代谢通路。本研究从分子水平阐述了高血压痰湿壅盛证的发病机制,并为其寻找诊断、鉴别诊断方法及药物作用靶点有一定启示作用。
[Abstract]:Objective: to study the interaction and biological pathway of metabolites in hypertensives with phlegm and dampness. Methods: a study on plasma metabolism in patients with hypertensives with phlegm-dampness syndrome was carried out from the databases of Zhiwang, Wanfang, Weipu and Embase. The metabolites included in the study were summarized. The signal pathway was analyzed by KEGG, the metabolites were annotated, the related enzymes or transporters and their related properties were analyzed by HMDB.The metPA network software was used to visualize the pathway of metabolites. Results: a total of 6 articles were included in the study, and 15 metabolites were involved in 28 metabolic pathways. Ten metabolic pathways with P < 0.05 were selected as metabolic pathways in hypertensives with phlegm-dampness accumulation syndrome, which were glycolysis and glycolytic effect, such as D-glutamine and D-glutamic acid metabolism, valine metabolism. Biosynthesis of leucine and isoleucine, pentose phosphate pathway, vitamin B6 metabolism, alanine metabolism, valine, leucine and isoleucine degradation, galactose metabolism, vitamin C metabolism, starch and sucrose metabolism. Conclusion: the biological information analysis of hypertensives with phlegm-dampness syndrome showed that its pathological mechanism was related to the metabolism of carbohydrate, fat, amino acid, vitamin and other substances and its metabolic pathway. In this study, the pathogenesis of hypertensives with phlegm-dampness syndrome was expounded at the molecular level, and the diagnosis, differential diagnosis methods and drug action targets were found to be enlightening for the pathogenesis of hypertension-phlegm-dampness syndrome.
【作者单位】：广西中医药大学;广西中医药大学附属瑞康医院;
【基金】：国家自然科学基金(81360535) 广西科学研究与技术开发计划项目(桂科攻1598012-55) 广西壮族自治区教育厅,广西高等学校优秀中青年骨干教师培养工程资助(桂教人[2013]16号)
【分类号】：R259

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