补肾健脾中药复方预防椎体成形术后再骨折的随访研究

发布时间：2018-04-29 11:01

本文选题：骨质疏松 + 椎体成形术　；参考：《中国骨质疏松杂志》2017年05期

【摘要】：目的评价补肾健脾中药复方对骨质疏松性椎体骨折椎体成形术后再骨折的预防作用。方法 92例因骨质疏松性椎体骨折而行椎体成形术的患者随机分为观察组和对照组,每组46例。所有患者进行12月随访,期间记录患者出院时、术后3个月、末次随访的骨密度情况和椎体骨折情况,并采用Oswestry功能障碍指数分记录患者功能情况。结果最终纳入统计的患者85例,其中观察组43例和对照组42例。在骨密度方面,观察组腰椎和髋部骨密度呈上升趋势,对照组的骨密度呈下降趋势,而且腰椎和髋部的末次随访的骨密度与出院时比较,其差异有统计学意义(P0.05)。观察组和对照组在术后3个月髋部骨密度方面,差异有统计学意义(P0.05),两者在末次随访时腰椎骨密度和髋部骨密度比较,差异有统计学意义(P0.05)。在椎体是否再发骨折方面,在末次随访时,观察组有2例骨折,对照组有8例骨折,经比较,两者差异有统计学意义(P0.05)。在功能改善方面,观察组在术后3个月和末次随访时的功能优于对照组,其差异有统计学意义(P0.05)。结论补肾健脾中药复方能提高骨密度,有效维持骨密度的变化,降低椎体再骨折的风险,而且能明显改善患者术后的功能和症状。
[Abstract]:Objective to evaluate the preventive effect of tonifying kidney and invigorating spleen compound on vertebral refracture after vertebroplasty for osteoporotic vertebral fracture. Methods 92 patients with osteoporotic vertebral fracture were randomly divided into observation group (n = 46) and control group (n = 46). All patients were followed up for 12 months. The bone mineral density (BMD) and vertebral fracture were recorded at the time of discharge, 3 months after operation and the last follow-up. The functional status of patients was recorded by Oswestry dysfunction index. Results 85 patients were included in the statistics, including 43 cases in the observation group and 42 cases in the control group. In terms of BMD, the BMD of lumbar vertebrae and hip showed an upward trend in the observation group, and the BMD of the control group decreased, and the BMD of the last follow-up of the lumbar vertebrae and hip was significantly higher than that of the discharged patients (P 0.05). There was a significant difference in bone mineral density of hip between the observation group and the control group at 3 months after operation (P 0.05), and the difference between the two groups at the last follow-up was significant (P 0.05). At the last follow-up, there were 2 cases of fracture in the observation group and 8 cases in the control group. The difference between the two groups was statistically significant (P 0.05). In terms of functional improvement, the function of the observation group was better than that of the control group at 3 months and the last follow-up, and the difference was statistically significant (P 0.05). Conclusion the compound prescription of tonifying kidney and invigorating spleen can increase BMD, maintain the change of BMD, reduce the risk of vertebral refracture, and improve the function and symptoms of patients after operation.
【作者单位】：广东省中西医结合医院;广州中医药大学;
【基金】：广州市珠江科技新星项目(2012J2200037) 佛山市科技创新平台建设项目(2013AG100022)
【分类号】：R274.9

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