湿热痹阻型类风湿关节炎中医内外合治的临床数据挖掘研究

发布时间：2018-05-01 08:40

本文选题：类风湿关节炎(RA) + 中医药　；参考：《新中医》2017年04期

【摘要】：目的:对1 124例湿热痹阻型类风湿关节炎(RA)住院患者的病历资料进行回顾性研究,从中医辨证用药、外治法、实验室指标等方面探讨中医内外合治湿热痹阻型RA的治疗特色。方法:根据是否使用外治法分为单纯内治组、内外合治组,基于临床数据挖掘技术和复杂网络技术,收集与分析1 124例湿热痹阻型RA住院患者的中医辨证用药、内外合用药、实验室指标等情况。结果:2组临床辨证用药可以分为清热解毒、健脾化湿、祛风除湿、活血通络4类,用药总频次以健脾化湿药最高。外治用药以芙蓉膏、消瘀接骨散为主。治疗后,2组患者的免疫、炎症、氧化应激指标均较治疗前有所改善,差异均有统计学意义(P0.05,P0.01);内外合治组α1-酸性糖蛋白(α1-AGP)、抗环瓜氨酸肽抗体(CCP-AB)、IgG、IgA与谷丙转氨酶(ALT)、谷草转氨酶(AST)的改善较单纯内治组显著,差异均有统计学意义(P0.05,P0.01)。结论:中医内外合治可有效改善湿热痹阻型RA患者的免疫、炎症、氧化应激指标,安全性好,其作用于免疫、炎症、氧化应激的机制需进一步研究。
[Abstract]:Objective: to retrospectively study the medical records of 1 124 cases of rheumatoid arthritis (RA) with damp-heat arthralgia, and to explore the characteristics of internal and external treatment of rheumatoid arthritis (RA) with internal and external combination of traditional Chinese medicine (TCM) in the treatment of dampness and heat resistance (RA) from the aspects of TCM syndrome differentiation and medication, external treatment and laboratory indexes. Methods: according to whether the external treatment method was used or not, the patients were divided into two groups: internal treatment group and internal and external treatment group. Based on clinical data mining technology and complex network technology, 1 124 cases of inpatients with damp-heat arthralgia obstruction type RA were collected and analyzed. Laboratory indicators, etc. Results the two groups could be divided into four groups: clearing heat and detoxification, invigorating spleen and dehumidifying, expelling wind and dehumidifying, activating blood circulation and dredging collaterals, and the total frequency of medicine was the highest. External medicine to Furong ointment, Xiaoyu Jiegu San mainly. After treatment, the immune, inflammatory and oxidative stress indexes of the two groups were improved compared with those before treatment. The improvement of 伪 1-AGPP (伪 1-AGPN), anti-cyclic citrullin-peptide antibody (CCP-ABG) IgA and alanine aminotransferase (alt), aspartate aminotransferase (AST) in the combined treatment group was significantly higher than that in the control group (P 0.05, P 0.01). Conclusion: the combination of internal and external treatment of TCM can effectively improve the immunity, inflammation, oxidative stress index and safety of RA patients with damp-heat arthralgia. The mechanism of its action on immunity, inflammation and oxidative stress needs further study.
【作者单位】：安徽中医药大学研究生院;安徽中医药大学第一附属医院;
【基金】：国家中医药重点学科中医痹病学建设项目(国中医药发[2009]30号) 国家临床重点专科中医风湿病科建设项目(财社[2013]239号) 国家科技支撑计划课题(2012BA126B02) 安徽省重点实验室:现代中医内科应用基础与开发研究(1606c08238)
【分类号】：R259

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