基于功能磁共振成像的针刺治疗面瘫的可能机制研究

发布时间：2018-05-03 05:02

本文选题：面瘫 + 功能磁共振　；参考：《中国科学技术大学》2016年硕士论文

【摘要】：贝尔氏面瘫是常见的由面部神经受损引发的疾病,多表现为特发的、单一的面部麻痹。其主要发病原因是面神经水肿而引发支配面部运动的神经回路受损,但其面神经水肿的最初原因还未得证实。针灸是中国传统的医疗手段之一,在亚洲,针灸常被用于治疗面瘫。虽然针灸治疗的机制尚不清晰,但其临床疗效却有目共睹。在针灸治疗面瘫中,面瘫侧对侧的合谷穴是首要针刺穴位,但有时也会选择同侧的合谷穴作为治疗穴位。但是,同侧针刺与对侧针刺促使面瘫的康复机制是否相同却未曾证实。本研究基于此,借助功能磁共振的手段,通过研究针灸诱导的初级躯体感觉皮层(SI)的功能连接变化,来探究同侧针刺和对侧针刺的作用机制是否存在差异。本文具体研究内容是探究同侧针刺与对侧针刺诱导的SI功能连接改变情况。本研究分为两组实验组及一组健康对照组,实验采集了所有被试静息态功能磁共振数据及健康人任务态功能磁共振数据。本研究首先通过计算健康人任务态数据获取种子点即双侧Si的具体位置。再对各组针刺前针刺后的数据计算了双侧Si功能连接的状况。实验比较了各组内针刺前与针刺后双侧SI功能连接的情况,其显示同侧针刺与健康人针刺前后双侧SI功能连接没有明显改变,而对侧针刺组出现了明显改变。基于此结果,本文对对侧针刺诱导的SI功能连接改变区域进行了深入探讨。在此基础上,本研究进·步采取了差检验的方法,比较了同侧针刺与对侧针刺诱导双侧Si功能连接改变的差异性。其结果显示,同侧针刺与对侧针刺前后SI功能连接的改变存在差异性。基于此,本文还推测了针刺治疗面瘫的可能机制。
[Abstract]:Bell's facial palsy is a common disease caused by facial nerve damage, characterized by idiopathic, single facial paralysis. The main cause of facial nerve edema is the damage of the nerve circuit which innervates facial movement, but the initial cause of facial nerve edema has not been proved. Acupuncture is one of the traditional medical methods in China. In Asia, acupuncture is often used to treat facial paralysis. Although the mechanism of acupuncture and moxibustion therapy is not clear, its clinical effect is obvious to all. In acupuncture and moxibustion treatment of facial paralysis, Hegu point on the opposite side of facial paralysis is the primary acupuncture point, but sometimes it also chooses the same side Hegu point as the treatment point. However, the recovery mechanism of ipsilateral acupuncture and contralateral acupuncture for facial paralysis has not been proved. Based on this, the functional connection of primary somatosensory cortex (SI) induced by acupuncture and moxibustion was studied by means of functional magnetic resonance (fMRI) to explore whether there are differences in the mechanism of ipsilateral acupuncture and contralateral acupuncture. The purpose of this study is to explore the changes of SI functional junctions induced by ipsilateral acupuncture and contralateral acupuncture. This study was divided into two groups: two experimental groups and one healthy control group. The rest functional magnetic resonance (fMRI) data and the task-state functional magnetic resonance (fMRI) data of all subjects were collected. In this study, the specific position of the seed point, namely bilateral Si, was obtained by calculating the task state data of healthy people. The data of each group before and after acupuncture were used to calculate the status of bilateral Si functional connections. The bilateral SI functional connections before and after acupuncture in each group were compared. The results showed that there were no significant changes in the bilateral SI functional junctions between the ipsilateral acupuncture group and the healthy subjects before and after acupuncture, but the contralateral acupuncture group showed obvious changes. Based on these results, the changes of SI functional junctions induced by lateral acupuncture are discussed in detail. On this basis, the difference between ipsilateral acupuncture and contralateral acupuncture induced changes of bilateral Si functional junctions was compared. The results showed that the changes of SI functional junctions before and after ipsilateral acupuncture and contralateral acupuncture were different. Based on this, we also speculate the possible mechanism of acupuncture treatment of facial paralysis.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.6;R445.2

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