芪参通络饮对稳定型心绞痛患者（气虚血瘀型）运动耐量及血清SOD和MDA水平的影响

发布时间：2018-05-03 07:17

本文选题：芪参通络饮 + 稳定型心绞痛　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察芪参通络饮治疗冠心病稳定型心绞痛(气虚血瘀型)的运动耐量及对血清SOD和MDA水平的影响。方法:根据纳入标准与排除标准,将符合纳入标准的60例冠心病稳定型心绞痛患者按照随机数表法随机分为治疗组30例和对照组30例,治疗组应用芪参通络饮口服加万爽力并配合常规治疗,对照组予万爽力口服同时配合常规治疗,观察周期为4周,即28天,主要观察结果为,观察治疗前后心绞痛发作症状情况、中医证候情况、中医症状积分、硝酸甘油停减率,运动平板试验总时间、代谢当量、血清SOD水平、血清MDA水平以及血、尿、便常规和肝肾功能等的变化。结果:1.经治疗,中医症状积分治疗组与对照组分别与治疗前进行比较,治疗组与对照组相较于治疗前均明显降低,差异具有统计学意义,具有及显著性差异(P0.01),说明两组治疗对于中医症状积分均有意义。治疗组与对照组的治疗情况进行比较时,治疗组疗后的的中医症状积分明显低于对照组疗后的中医症状积分,差异有统计学意义(P0.05),具有显著性差异,说明治疗组与对照组在治疗前后均能使中医症状积分明显降低,并且治疗组与对照组进行比较时,治疗组的对于中医症状积分的治疗情况优于对照组。2.经治疗,比较治疗后情况,治疗组患者对于心绞痛疗效、硝酸甘油停减率与中医证候疗效这三个方面的的总有效率,治疗组的治疗情况较对照组来说均高于对照组,差异有统计学意义(P0.05),具有显著性差异,说明治疗组对于心绞痛、硝酸甘油停减率与中医证候这三个方面的治疗效果要优于对照组。3.经治疗,比较治疗后情况,治疗组运动平板试验的总时间和代谢当量这两个方面较治疗前相比较都有明显增高,差异有统计学意义(P0.01),具有及其显著性差异;对照组运动平板试验的总时间治疗前后比较有所增高,差异有统计学意义(P0.05),具有显著性差异;对照组代谢当量治疗前后比较明显增高,差异有统计学意义(P0.05),具有显著性差异;说明对照组运动平板试验的总时间和代谢当量,治疗后的治疗组与对照组进行组间比较均有差异,有统计学意义(P0.05),具有显著性差异。说明平板试验的总时间和代谢当量,治疗组优于对照组(P0.05)。说明治疗组与对照组的治疗情况分别相较于治疗前来说都有差异,且治疗组的治疗情况优于对照组。4.经治疗,治疗组和对照组患者血清中治疗前后的SOD含量均有显著升高,MDA均有显著降低,差异有显著性意义(P0.01),说明治疗前后,治疗组与对照组均能使血清中SOD含量显著升高,MDA显著降低,两组治疗前后比较,对于患者SOD水平和MDA水平的改善情况均有统计学差异。两组间相比较,血清中SOD含量有所升高,MDA含量有所降低,差异有统计学意义(P0.05),具有显著性差异。说明治疗组和对照组血清中治疗前后的SOD含量水平与MDA含量水平这两方面与治疗前相比均有明显改变,而且相对于的SOD含量水平与MDA含量水平这两方面且治疗组的治疗效果优于对照组。结论:1.芪参通络饮能够改善冠心病稳定型心绞痛(气虚血瘀型)患者的心绞痛疗效、中医症状积分、中医证候以及提高硝酸甘油停减率。2.芪参通络饮能够明显提高冠心病稳定型心绞痛(气虚血瘀型)患者的运动耐量。3.芪参通络饮能够使冠心病稳定型心绞痛(气虚血瘀型)患者的SOD升高,MDA降低,发挥其抗氧化作用,从而起到治疗CHD的作用。
[Abstract]:Objective: To observe the effect of Qisheng Tongluo Decoction on the exercise tolerance and the level of serum SOD and MDA in stable angina pectoris (Qi deficiency and blood stasis type). Methods: according to the standard and exclusion criteria, 60 patients with stable angina pectoris were randomly divided into 30 cases and 30 cases in the control group according to the random number table method. The treatment group was treated with Qisheng Tongluo Decoction plus Wan Shuang force combined with conventional treatment. The control group was given Wan Shuang force oral and routine treatment. The observation period was 4 weeks, that is, 28 days, the main observation results were, the symptoms of angina pectoris, TCM syndromes, the symptom score of Chinese medicine, the rate of nitroglycerin withdrawal, and exercise plate test were observed before and after treatment. Total time, metabolic equivalent, serum SOD level, serum MDA level, blood, urine, urine, routine and liver and kidney function and other changes. Results: 1. the treatment group and the control group compared with the control group before treatment, the treatment group and the control group were significantly lower than the control group before treatment, the difference was statistically significant, and the difference was significant difference. Difference (P0.01), indicating that two groups of treatment for the TCM symptom score has significance. The treatment group compared with the control group, the treatment group after the treatment of the TCM symptom score was significantly lower than the control group after the treatment of traditional Chinese medicine symptom score, the difference was statistically significant (P0.05), with significant differences, indicating the treatment group and the control group before treatment. After the treatment group was compared with the control group, the treatment group was better than the control group when compared with the control group. The treatment group was better than the control group.2., compared with the treatment group, the treatment group was more effective in the three aspects of the curative effect of angina pectoris, the reduction rate of nitroglycerin and the curative effect of TCM syndrome. Compared with the control group, the treatment group was higher than the control group. The difference was statistically significant (P0.05), with significant difference. The treatment group was better than the control group.3. treatment for angina, nitroglycerin reduction and TCM syndrome, compared with the control group, after the treatment, the treatment group exercise tablet test in general. The two aspects of time and metabolic equivalent were significantly higher than those before treatment. The difference was statistically significant (P0.01) and had significant differences. The control group had a significant difference before and after the total time treatment of exercise plate test, the difference was statistically significant (P0.05), and the control group was compared before and after the metabolic equivalent treatment. The difference was statistically significant (P0.05), with significant difference. It showed that the total time and metabolic equivalent of the exercise plate test in the control group were different between the treatment group and the control group, with significant difference (P0.05). It showed that the total time and metabolic equivalent of the tablet test were superior to those in the treatment group. In the control group (P0.05), the treatment group was compared with the control group before the treatment, and the treatment group was better than the control group.4.. The SOD content in the treatment group and the control group before and after the treatment in the serum were significantly increased, and the MDA had a significant decrease, the difference was significant (P0.01). Before and after treatment, both the treatment group and the control group could significantly increase the content of SOD in the serum, and significantly decrease the MDA. The two groups were compared before and after treatment, and there were significant differences in the improvement of the level of SOD and MDA in the patients. Compared with the two groups, the content of SOD in the serum was increased and the content of MDA decreased, and the difference was statistically significant (P0.05). The difference was significant (P0.05). The two aspects of the level of SOD and the level of MDA before and after treatment in the treatment group and the control group were significantly different from those before the treatment, and compared with the two aspects of the level of SOD and the level of MDA, and the therapeutic effect of the treatment group was better than that of the control group. Conclusion: 1. Qi Shen Tongluo Decoction can improve the coronary heart disease. The effect of angina pectoris in patients with stable angina pectoris (Qi deficiency and blood stasis), TCM symptom score, TCM syndrome and improvement of the rate of stopping and subtraction of nitroglycerin.2. Qisheng Tongluo Decoction can obviously improve the exercise tolerance of.3. Qi Shen Tongluo Decoction (Qi Shen Tongluo Decoction) in patients with stable angina pectoris (Qi deficiency and blood stasis type), which can make the stable angina pectoris (Qi deficiency and blood stasis type) of coronary heart disease (Qi deficiency and blood stasis type) SOD increased and MDA decreased, exerting its antioxidant effect, thereby playing a role in the treatment of CHD.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

【参考文献】