细蝎胶囊治疗偏头痛（瘀血阻络型）临床观察

发布时间：2018-05-05 19:55

本文选题：偏头痛 + 中医疗法　；参考：《湖北中医药大学》2016年硕士论文

【摘要】：目的:通过观察细蝎胶囊对偏头痛(瘀血阻络证)患者的临床疗效、中医证候疗效、头痛影响测定评分以及偏头痛发作次数、天数、疼痛程度、持续时间及不良反应等指标的影响统计,以期能对细蝎胶囊在治疗偏头痛(瘀血阻络型)有效性以及安全性得出一个客观的结论,从而对其临床应用提出科学、合理依据。方法:本试验共选取了42例来自于2014年11月至2015年06月襄阳市中医院脑病科门诊就诊偏头痛(瘀血阻络型)患者,运用随机分组方法,组成各由21例患者组成的治疗组及对照组。治疗组给予单药口服细蝎囊(药物组成:细辛10g、全蝎10g、防风10g、刺蒺藜10g、川芎30g、白芷10g、桃仁10g、红花10g、白僵蚕10g。由本院药剂科制备),6粒/次,3次/日;对照组采用盐酸氟桂利嗪胶囊(由西安杨森制药公司生产),5mg/次,每晚睡前服用,所有患者的病程均在6个月以上,平均(2.2±1.4)年。所有患者均排除颈椎病、颅内占位性病变、脑卒中等疾病导致的头痛可能,同时还需要排除妊娠期女性以及有对治疗药物过敏史的患者。2组患者在基线期之前4周统计的关于性别、年龄、病程等一般资料上不存在显著差异(P0.05),两组比较具有统计学意义。在14天的疗程之后继续随访,每四周当面随访一次,每周电话随访,直至12周末结束随访,对其临床疗效以及安全性等数据进行综合统计,同时应用SPSS17.0软件对统计的相关数据进行分析,以此来观察两组患者治疗后在疗效、中医证候以及安全性上有无明显差异。结果:通过对细蝎胶囊疗效、中医证候及安全性等方面相关数据统计学分析,最后的结果表明在比较两组药物的临床疗效这一方面,治疗组5人临床痊愈,7人显效,6人有效,3人无效,总有效率为85.72%,对照组6人临床痊愈,6人显效,5人有效,4人无效,总有效率为80.96%,两组疗效无显著差异(P0.05),说明细蝎胶囊与盐酸氟桂利嗪胶囊在针对偏头痛的治疗方面上均有确切的疗效。但另一方面,在改善中医证候疗效上,治疗组与对照组两组经统计学分析有显著性差异(P0.05),这些结果充分表现出单用细蝎胶囊组对比于单用盐酸氟桂利嗪胶囊组在改善中医症候方面有独特的优势。而在安全性方面,治疗组相较于对照组没有相关不良事件报告提出,安全性良好。结论:细蝎胶囊在治疗瘀血阻络型偏头痛的治疗上面有效,同时在针对中医症候的改善上更是具有一些自身的优势,安全性良好。
[Abstract]:Objective: to observe the clinical effect of Scorpio capsule on patients with migraine (blood stasis blocking collateral syndrome), the curative effect of TCM syndromes, the score of headache influence, the number of migraine attacks, the days of migraine attack, and the degree of pain. In order to obtain an objective conclusion on the efficacy and safety of Scorpion capsule in the treatment of migraine (blood stasis and collateral obstruction type), the effect of duration and adverse reactions was analyzed, and the scientific and reasonable basis for its clinical application was put forward. Methods: from November 2014 to June 2015, 42 patients with migraine (blood stasis blocking collateral type) were selected from the Department of Encephalopathy, Xiangyang traditional Chinese Medicine Hospital, and were randomly divided into two groups. Each group consisted of 21 patients and the control group. The treatment group was given single drug oral Scorpion sac (drug composition: Asarum 10g, Scorpion 10g, Fangfeng 10g, Tribulus terrestris 10g, Chuanxiong 30g, dahurica 10g, peach kernel 10g, safflower 10g, white standosia 10g. The patients in the control group were treated with flunarizine hydrochloride capsule (5 mg / time produced by Xi'an Yang Sen Pharmaceutical Company) before bedtime every night. The course of disease of all patients was more than 6 months (average 2.2 卤1.4) years. All patients were excluded from headache caused by cervical spondylopathy, intracranial space-occupying lesions, stroke, etc. At the same time, there was no significant difference in general data of sex, age, course of disease and so on between group 2 and group .2 of pregnancy women and patients with history of drug allergy before the baseline period (P 0.05). The comparison between the two groups was statistically significant. They were followed up after 14 days of treatment, followed up in person every four weeks, followed by telephone every week until the end of 12 weeks. The clinical efficacy and safety data were analyzed. At the same time, the statistical data were analyzed by SPSS17.0 software to observe whether there were significant differences in curative effect, TCM syndromes and safety between the two groups after treatment. Results: according to the statistical analysis of Scorpion capsule's curative effect, TCM syndrome and safety, the final result shows that the clinical curative effect of the two groups is compared. The total effective rate was 85.72in the treatment group, while in the control group, 6 patients were cured and 6 patients were effective and 4 patients were ineffective, and the total effective rate of the treatment group was 85.722.In the control group, 6 patients were clinically cured and 6 patients were significantly effective. The total effective rate was 80.96, and there was no significant difference between the two groups (P 0.05), which indicated that Scorpion capsule and flunarizine Hydrochloride capsule had definite curative effect on migraine. On the other hand, on the other hand, in improving the curative effect of TCM syndromes, There was significant difference between the treatment group and the control group by statistical analysis. These results showed that the single scorpion capsule group had a unique advantage in improving TCM symptoms compared with the single flunarizine hydrochloride capsule group. In terms of safety, the safety of the treatment group was better than that of the control group. Conclusion: Scorpio capsule is effective in the treatment of migraine caused by blood stasis and obstruction of collaterals, and has some advantages and good safety in the improvement of TCM symptoms.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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