耳穴贴压对原发性痛经患者前列腺素及β-内啡肽等的影响

发布时间：2018-05-05 19:13

本文选题：耳穴贴压 + 原发性痛经　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的:通过研究耳穴贴压对原发性痛经患者前列腺素(PGF2α、PGE2、PGF2α/PGE2)、β-EP、血栓素(TXA2、TXB2)的影响,探讨耳穴贴压防治原发性痛经的效应机制,为推广应用耳穴贴压防治原发性痛经提供实验依据。方法:耳穴贴压组随机选入原发性痛经患者18例,正常对照组随机选入身体健康女大学生14例。耳穴取穴内生殖器、内分泌、交感、皮质下、神门、肝、肾,每日按压4次,每次间隔4小时,每次每穴按压20次,于第3日更换对侧耳穴,连续治疗3个月经周期。均于治疗前(纳入实验后的第一个月经周期)月经来潮24h内及治疗后(治疗组治疗的第三个月经周期)月经来潮24h内采集血液样本。采用酶联免疫法测定血清前列腺素(PGF2α、PGE2)、β-EP、血栓素(TXA2、TXB2)的含量。结果:1.耳穴贴压组治疗前PGF2α、PGE2含量和PGF2α/PGE2值均高于正常对照组水平(P0.05),治疗后PGF2α、PGE2、PGF2α/PGE2值水平均有所下降(P0.05),PGF2α/PGE2值与正常对照组无差异(P0.05)。2.耳穴贴压组β-EP含量在治疗前与正常对照组相当,差异无统计学意义(P0.05),治疗后耳穴贴压组β-EP含量明显高于治疗前(P0.01)和正常对照组(P0.01)。3.耳穴贴压组治疗前TXA2、TXB2均高于正常对照组(P0.01),治疗后TXA2、TXB2水平明显下降(P0.01),与正常对照组无差异(P0.05)。结论:耳穴贴压防治原发性痛经的效应机制,可能与调节原发性痛经患者前列腺素(PGF2α、PGE2、PGF2α/PGE2)、β-EP、血栓素(TXA2、TXB2)水平相关。
[Abstract]:Objective: to study the effect of auricular point plaster pressure on PGE2a / PGE2 伪 / PGE2 伪, 尾 -EPand TXA2TXB2 in patients with primary dysmenorrhea, and to explore the mechanism of auricular acupoint plaster pressure in the prevention and treatment of primary dysmenorrhea, so as to provide experimental basis for popularizing the treatment of primary dysmenorrhea by auricular plaster pressure. Methods: 18 cases of primary dysmenorrhea were randomly selected into auricular acupoint pressing group and 14 cases of healthy female college students were randomly selected into normal control group. The internal genitalia, endocrine, sympathetic, subcortical, Shenmen, liver, kidney, pressing 4 times daily, every time 4 hours, each point pressing 20 times, on the third day to replace the contralateral auricular points, continuous treatment for 3 menstrual cycles. Blood samples were collected within 24 hours of menorrhagia before treatment (the first menstrual cycle after the experiment) and within 24 hours after menorrhagia (the third menstrual cycle of treatment group). The levels of serum prostaglandin PGF2 伪, 尾 -EPand TXA2TXB2 were determined by enzyme-linked immunosorbent assay (Elisa). The result is 1: 1. The content of PGF2 伪 PGE2 and PGF2 伪 / PGE2 before treatment in auricular acupoint plaster group were higher than those in normal control group (P 0.05). After treatment, the levels of PGF2 伪 PGE2 伪 PGE2 伪 / PGE2 / PGE2 decreased, and there was no significant difference between the two groups in PGF2 伪 / PGE2 / PGE2 value compared with the normal control group (P0.05PGE2 / PGE2). The content of 尾 -EP in the auricular point plaster group was similar to that in the normal control group before treatment, and the difference was not statistically significant (P 0.05). After treatment, the 尾 -EP content in the auricular point pressing group was significantly higher than that in the auricular point pressing group before treatment (P 0.01) and in the normal control group (P 0.01). The levels of TXA _ 2 and TXB _ 2 in auricular acupoint plaster group were higher than those in normal control group before treatment (P 0.01). After treatment, the level of TXA _ 2 and TXB _ 2 decreased significantly (P _ (0.01)), but there was no difference between the two groups (P _ (0.05)). Conclusion: the mechanism of auricular plaster pressure in preventing and treating primary dysmenorrhea may be related to regulating the level of PGF 2 伪 / PGE 2 伪 / PGE 2 伪, 尾 -EPK, TXA 2 and TXB 2 in patients with primary dysmenorrhea.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.3

【引证文献】