通窍回聪汤加减治疗气滞血瘀型突发性耳聋的临床研究

发布时间：2018-05-08 10:05

本文选题：通窍回聪汤 + 突发性耳聋　；参考：《福建中医药大学》2016年硕士论文

【摘要】：目的：观察通窍回聪汤联合常规治疗对气滞血瘀型突发性耳聋(sudden hearing loss, SHL)的临床疗效。探讨中医药在突发性耳聋治疗中促进听力恢复、减轻伴随症状、缩短疗程中的作用及其相关机理,以寻找突发性耳聋较为理想的中医治疗方法及方药,为临床治疗突发性耳聋提供更好的中医理论参考及有效治疗原则。方法:观察突发性耳聋的住院患者共60例,随机分为治疗组和对照组,每组各30例。治疗组采用通窍回聪汤加减联合常规治疗,对照组采用常规治疗,共治疗2周。利用纯音听阈测定及听性脑干反应测试检查来评判应用通窍回聪汤联合常规治疗与单纯常规治疗前后的疗效差异,并记录两组治疗前、治疗后耳鸣改善情况,按照疗效评定标准,对数据进行统计分析以评价中药联合常规治疗的疗效。结果:1、治疗1周后,对比两组的听力提高程度,治疗组有效率61.29%,对照组有效率56.25%,经统计学比较两组有效率P=0.0200.05,具有统计学差异,治疗组优于对照组。2、治疗2周后,两组听力情况比较,治疗组有效率77.42%,对照组有效率71.88%经统计学观察两组有效率P=0.0340.05,具有统计学差异,治疗组优于对照组。3、治疗2周后比较两组治疗前后平均气导听阂差值,治疗组平均差值18.27± 8.55dBHL,对照组前后平均差值15.09±7.37dBHL,经统计学观察两组有效率P0.05,具有统计学差异,治疗组提升幅度优于对照组。4、两组患者治疗前后耳鸣等级分布情况比较,差异均有统计学意义(Z=-3.162,P=0.03 10.05),即两种治疗方法在减轻耳鸣症状均有效,治疗组明显优于对照组。5、治疗结束后,两组患者均无特殊不适,查肝功、肾功未见明显异常,表明通窍回聪汤无肝肾损害。结论1、对突发性耳聋造成的听力下降及耳鸣,两组药物均有一定的作用,通窍回聪汤联合常规治疗优于常规治疗方案。2、通窍回聪汤是治疗突发性耳聋安全、有效的方剂,值得临床推广。
[Abstract]:Objective: to observe the clinical effect of Tongqiao Huicong decoction combined with routine treatment on sudden deafness due to Qi stagnation and blood stasis. To explore the effect of traditional Chinese medicine (TCM) in the treatment of sudden deafness, to promote the recovery of hearing, to alleviate the accompanying symptoms, to shorten the course of treatment and its related mechanism, in order to find the ideal TCM treatment method and prescription for sudden deafness. For clinical treatment of sudden deafness to provide a better theoretical reference and effective treatment principles. Methods: 60 patients with sudden deafness were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Tongqiao Huicong decoction combined with conventional therapy, while the control group was treated with conventional therapy for 2 weeks. Pure tone hearing threshold test and auditory brainstem response test were used to evaluate the curative effect of Tongqiao Huicong decoction combined with conventional treatment and simple routine treatment, and to record the improvement of tinnitus before and after treatment in the two groups. According to the evaluation criteria, the data were statistically analyzed to evaluate the efficacy of traditional Chinese medicine combined with conventional therapy. Results one week after treatment, the hearing improvement of the two groups was compared. The effective rate of the treatment group was 61.29 and that of the control group was 56.25.The effective rate of the two groups was 0.0200.05. there was statistical difference between the two groups. The treatment group was better than the control group, and the treatment group was better than the control group. After 2 weeks of treatment, the effective rate of the treatment group was better than that of the control group. The effective rate of the treatment group was 77.42%, and that of the control group was 71.88%. The effective rate of the two groups was 0.0340.05. there was statistical difference between the two groups. The treatment group was superior to the control group (.3.) after 2 weeks of treatment, the difference of the average air-conduction hearing barrier between the two groups before and after treatment was compared. The average difference was 18.27 卤8.55dBHLin the treatment group and 15.09 卤7.37dBHLin the control group. The effective rate of the two groups was significantly higher than that of the control group (P0.05). The improvement range of the treatment group was better than that of the control group (.4). The distribution of tinnitus grade before and after treatment was compared between the two groups. The difference was statistically significant. The two treatment methods were effective in alleviating tinnitus symptoms, and the treatment group was superior to the control group. After the treatment, there was no special discomfort in both groups, and the liver function and renal function were not abnormal. It showed that Tongqiao Huicong decoction had no liver and kidney damage. Conclusion 1. Both drugs have certain effects on hearing loss and tinnitus caused by sudden deafness. Tongqiao Huicong decoction combined with routine treatment is superior to routine treatment plan. Tongqiao Huicong decoction is a safe and effective prescription for treating sudden deafness. It is worth popularizing in clinic.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R276.1

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