左金丸合四逆散治疗肝郁脾虚型溃疡性结肠炎疗效及其对血清促炎因子和抗炎因子水平的影响

发布时间：2018-05-09 00:06

本文选题：左金丸 + 四逆散　；参考：《中药药理与临床》2017年02期

【摘要】：目的:探讨左金丸合四逆散治疗肝郁脾虚型溃疡性结肠炎疗效及其对血清促炎因子(i NOS、NO、TNF-α、IL-1β和IL-6)和抗炎因子(IL-4、IL-10)水平的影响。方法:选取经中医辨证为肝郁脾虚型溃疡性结肠炎患者66例,分为柳氮磺吡啶组(对照组)及左金丸合四逆散组(治疗组),每组33例。对照组口服柳氮磺吡啶1.0g/次,4次/d;治疗组水煎取左金丸合四逆散300ml,分早晚两次各150ml服用。两组疗程均为21d。治疗前后取静脉血采用分光光度法和ELISA检测血清中i NOS、NO、TNF-α、IL-1β、IL-6和IL-4、IL-10水平的变化,另取健康志愿者32例静脉血作为正常对照组。结果:治疗组总有效率87.50%,对照组总有效率为67.74%(P0.05);治疗前两组i NOS、NO、TNF-α、IL-1β和IL-6水平明显升高,IL-4和IL-10明显降低;治疗后两组i NOS、NO、TNF-α、IL-1β和IL-6水平均显著降低,IL-4和IL-10水平明显升高;治疗前两组血清中i NOS、NO、TNF-α、IL-1β、IL-6和IL-4、IL-10水平没有差异,分别用相应的药物治疗后,上述指标均具有显著的改善,但治疗组的作用效果明显强于对照组。结论:左金丸合四逆散对肝郁脾虚型溃疡性结肠炎患者具有较好的治疗作用,它主要通过抑制其分泌i NOS、NO、TNF-α、IL-1β和IL-6促炎因子,促进其分泌IL-4和IL-10抗炎因子,进而恢复促炎因子和抗炎因子之间的平衡来发挥对肝郁脾虚型溃疡性结肠炎患者的治疗作用。
[Abstract]:Objective: to investigate the therapeutic effect of Zuo Jin Pill combined with Sini Powder in treating ulcerative colitis with liver depression and spleen deficiency and its effect on the levels of serum TNF- 伪尾 and IL-6) and IL-4 IL-10. Methods: 66 cases of ulcerative colitis with syndrome differentiation of liver stagnation and spleen deficiency were divided into two groups: control group (control group) and Zuo Jin pill combined with Sini powder group (33 cases in each group). The control group was given 1.0g/ 4 times / d, and the treatment group was treated with Zuo Jin Pu he Sini San (300ml). 150ml was taken twice in the morning and evening. The course of treatment was 21 days in both groups. Before and after treatment, the changes of serum levels of iNOSNOSNON- 伪 TNF- 尾 IL-1 尾 IL-6 and IL-4 IL-10 were detected by spectrophotometry and ELISA, and 32 healthy volunteers were taken as normal control group. Results: the total effective rate was 87.50% in the treatment group and 67.74% in the control group (P 0.05), the levels of IL-1 尾 and IL-6 in the two groups were significantly increased and the levels of IL-4 and IL-10 were significantly decreased after treatment, and the levels of IL-4 and IL-10 increased significantly in the two groups after treatment. There was no difference between the two groups in the serum levels of iNOSN, TNF- 伪, IL-1 尾, IL-6 and IL-4 IL-10 before treatment. The above indexes were significantly improved after treatment with corresponding drugs, but the effect of the treatment group was significantly better than that of the control group. Conclusion: Zuo Jin Pill combined with Sini Powder has a better therapeutic effect on patients with ulcerative colitis of liver stagnation and spleen deficiency type. It can promote the secretion of IL-4 and IL-10 by inhibiting the secretion of iNOSN TNF- 伪 TNF- 伪 IL-1 尾 and IL-6 pro-inflammatory factor. Then restore the balance between proinflammatory factor and anti-inflammatory factor to play a therapeutic role in patients with ulcerative colitis of liver stagnation and spleen deficiency.
【作者单位】：三峡大学第一临床医学院/宜昌市中心人民医院;三峡大学医学院;三峡大学仁和医院;
【基金】：湖北省自然科学基金(No.2012FFC123) 湖北省卫计委中医药中西医结合科研项目(No,2013Z-Y16)
【分类号】：R259

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