基于降压中药药性统计分析探讨高血压病的中医证素特点与用药规律

发布时间：2018-05-09 01:02

本文选题：降压中药 + 高血压　；参考：《湖南中医药大学》2016年硕士论文

【摘要】：目的:通过对降压中药药性(功效、五味、归经、四气)的统计分析来探讨高血压病的中医证素特点与用药规律,以期为高血压病的中医辨证分型研究和进一步研究中医治疗该病提供参考。方法:利用万方数据库、CNKI等检索数据库针对2005~2015年所报道的单味中药治疗高血压病的文献进行检索,搜集可降血压的单味中药,并对其功效及药性(四气、五味、归经)进行统计分析,从而探讨高血压病的中医证素特点与用药规律。结果:共检索出符合纳入标准的单味中药降血压文献365篇,降血压的单味中药共87味;聚类及主成分分析结果显示:中药四气共2个公因子:寒、凉,累积贡献率为71.52%,有统计学意义;功效共5个公因子:清热、平肝、活血、补阴、化痰,累积贡献率为74.32%,有统计学意义;五味共3个公因子:苦、甘、辛,累积贡献率为86.67%,有统计学意义;归经共5个公因子:肝经、肾经、肺经、心经、脾经,累积贡献率为71.04%,有统计学意义。结论:共搜集到降压中药87味。降压中药的功效以清热、平肝、活血、补阴、化痰为主;四气以寒凉为主;五味以苦、甘、辛为主;归经主要归肝经,其次为肾经、肺经、心经、脾经。从而推论高血压病中医病位证素主要在肝、肾、肺、心、脾,尤以肝最为密切;中医病性证素以热(火)、阳亢、血瘀、阴虚、痰浊为主。高血压病的中医用药规律为:临床上注重从肝、肾来论治高血压病,用药时多选用苦、甘、辛的寒凉药物,并选择性重用清热泻火、滋阴潜阳、活血化瘀、化痰的降压中药。
[Abstract]:Objective: to explore the characteristics of TCM syndromes and the law of drug use in hypertension by statistical analysis of the medicinal properties (efficacy, five flavors, meridians, and four qi) of traditional Chinese medicine for lowering blood pressure. In order to provide a reference for the study of TCM syndrome differentiation and further study on TCM treatment of hypertension. Methods: by using CNKI database of Wanfang and other retrieval databases, we searched the literatures reported from 2005 to 2015 on the treatment of hypertension with single Chinese medicine, collected the single Chinese medicine that can lower blood pressure, and analyzed its efficacy and properties (four qi, five flavors). In order to explore the characteristics of TCM syndromes and drug use law of hypertension. Results: a total of 365 articles of single Chinese medicine for lowering blood pressure were found, 87 of which were single herbs. The results of cluster and principal component analysis showed that there were two common factors: cold, cool, cold, cool, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold, cold and cool. The cumulative contribution rate is 71.52, which has statistical significance; the efficacy of five common factors: clearing heat, calming the liver, activating blood circulation, tonifying yin, resolving phlegm, cumulative contribution rate is 74.322.There are three common factors: bitter, sweet, Xin, The cumulative contribution rate was 86.67, which was statistically significant, and there were five common factors: liver, kidney, lung, heart and spleen, and the cumulative contribution rate was 71.04, which was statistically significant. Conclusion: 87 kinds of antihypertensive herbs were collected. The efficacy of traditional Chinese medicine to reduce blood pressure in order to clear heat, calming the liver, activating blood, tonifying yin, phlegm; four qi to cold mainly; five flavors to bitter, sweet, Xin mainly; return to the main liver meridian, followed by the kidney, lung, heart, spleen meridian. It can be concluded that TCM syndrome factors of hypertension are mainly in liver, kidney, lung, heart, spleen, especially liver; heat is the most important factor in TCM disease syndrome (fire, Yang hyperactivity, blood stasis, yin deficiency, phlegm turbidity). The law of traditional Chinese medicine used in hypertension is: the treatment of hypertension from liver and kidney, the cold and cool medicine of bitter, sweet and Xin, and selective reuse of antihypertensive Chinese medicine of clearing heat and reducing fire, nourishing yin and burying yang, activating blood circulation and removing blood stasis, resolving phlegm.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【参考文献】