清热活血方剂干预冠心病心绞痛瘀热互结证临床观察

发布时间：2018-05-12 15:33

本文选题：冠心病心绞痛 + 瘀热互结证　；参考：《中华中医药杂志》2017年09期

【摘要】：目的:评价清热活血方对冠心病心绞痛瘀热互结证临床疗效。方法:选取中国中医科学院广安门医院心血管科冠心病心绞痛患者60例,用随机数字表法分为治疗组和对照组各30例。治疗组患者服用清热活血方,1剂/次,2次/d,联合常规西药,对照组服用安慰剂颗粒,1剂/次,2次/d,联合常规西药,疗程均为4周。治疗前后分别记录发作次数、持续时间、硝酸甘油用量,记录十二导联心电图检查,进行中医证候疗效积分评分,检测炎性因子指标超敏C反应蛋白(hs-CRP),检测安全性指标。结果:治疗组心绞痛症状疗效有效率(76.7%)优于对照组(40.0%)(P0.05),治疗组患者治疗后心绞痛发作次数与心绞痛发作持续时间显著减少(P0.01),疗效优于对照组(P0.05);心电图疗效和硝酸甘油停减率两组比较,无显著差异;中医证候疗效积分改善显著优于对照组(P0.05),在具体中医症状的改善上,治疗组"胸闷""心悸"两项的改善明显优于对照组(P0.05);治疗组治疗后hs-CRP显著降低(P0.01),且优于对照组(P0.05)。结论:清热活血方可以改善冠心病心绞痛瘀热互结证患者临床症状,能改善心肌缺血,抑制心血管炎性反应,值得临床推广应用。
[Abstract]:Objective: to evaluate the clinical effect of Qingre Huoxue recipe (QHR) on angina pectoris syndrome of coronary heart disease. Methods: sixty patients with angina pectoris of coronary heart disease in Guanganmen Hospital of Chinese Academy of traditional Chinese Medicine were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). The patients in the treatment group were treated with 1 dose of Qingre Huoxue recipe / 2 times / d, combined with conventional western medicine, while the control group took 1 dose of placebo granule / twice a day, and combined with routine western medicine, the course of treatment was 4 weeks. Before and after treatment, the attack times, duration, nitroglycerin dosage were recorded, 12-lead electrocardiogram was recorded, TCM syndromes curative effect score, inflammatory factor index, hypersensitive C-reactive protein hs-CRPU, safety index were detected. Results: the effective rate of symptoms of angina pectoris in the treatment group was 76.7%), which was better than that in the control group (40.0%). The frequency of angina pectoris attack and the duration of angina pectoris attack in the treatment group were significantly reduced after treatment, and the curative effect was better than that in the control group (P 0.05). The oil stoppage rate was compared between the two groups. The improvement of TCM syndromes curative effect integral was significantly better than that of the control group (P0.05A), and the improvement of the specific TCM symptoms was better than that of the control group. The improvement of "chest tightness" and "palpitation" in the treatment group was significantly better than that in the control group (P 0.05), and the hs-CRP in the treatment group was significantly lower than that in the control group (P 0.01) and better than that in the control group (P 0.05). Conclusion: Qingre Huoxue prescription can improve the clinical symptoms of patients with angina pectoris syndrome of blood stasis and heat interaction, can improve myocardial ischemia, inhibit cardiovascular inflammatory reaction, and is worthy of clinical application.
【作者单位】：中国中医科学院广安门医院心血管科;
【基金】：国家“重大新药创制”科技重大专项(No.2013ZX09301307)~~
【分类号】：R259

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