健脾益肾排毒法治疗慢性肾功能衰竭的系统评价

发布时间：2018-05-13 01:23

本文选题：健脾益肾排毒法 + 慢性肾衰竭　；参考：《湖北中医药大学》2016年硕士论文

【摘要】：目的:通过系统评价的方法,分析健脾益肾排毒法治疗慢性肾功能衰竭的疗效,找出目前慢性肾功能衰竭临床试验中存在问题,并为临床上制定治疗慢性肾功能衰竭的有效方案提供强有力的证据。方法:运用系统评价方法对数据库开库以来至2016年以健脾益肾排毒法治疗慢性肾功能衰竭的临床文献进行收集和分析,对符合标准的文献提取数据信息。然后采用Revman5.3进行meta分析,得出结论。结果:通过meta分析研究11篇临床文献表明,在应用西医常规治疗基础上联合健脾益肾排毒法的治疗方法相较于单纯用西医常规治疗,可以提高慢性肾功能衰竭患者的临床疗效,有效降低肌酐(Scr)、尿素氮(BUN),提高内生肌酐清除率(Ccr)、肾小球滤过率(e GFR)、血红蛋白(HGB),改善临床症状。11篇文献仅1篇指出未出现明显不良反应,余文献并未说明是否存在不良反应。结论:本研究表明在西医常规方法基础上加用健脾益肾排毒法与单独使用西医基础治疗结果比较,观察组疗效较对照组好,但因筛选出的文献质量相对偏低,还有着较大的偏倚,故应进一步展开样本量大的、随机的、多中心的临床研究。
[Abstract]:Objective: to analyze the effect of strengthening spleen and tonifying kidney and detoxifying toxin in the treatment of chronic renal failure by systematic evaluation, and to find out the existing problems in the clinical trials of chronic renal failure. It also provides strong evidence for effective treatment of chronic renal failure. Methods: a systematic evaluation method was used to collect and analyze the clinical literature on the treatment of chronic renal failure (CRF) with the method of tonifying spleen and tonifying the kidney and detoxifying toxin from the database from the beginning of the database to 2016, and to extract the data and information from the documents that accord with the standard. Then Revman5.3 is used for meta analysis and the conclusion is drawn. Results: according to the analysis of 11 clinical documents by meta, the clinical effect of the combined therapy of strengthening spleen, tonifying kidney and detoxification was improved compared with that of western medicine alone, which can improve the clinical effect of chronic renal failure patients. It can effectively reduce creatinine Scrs, urea nitrogen bun, increase the clearance rate of creatinine, glomerular filtration rate, hemoglobin HGBR, improve the clinical symptoms, only 1 article points out that there is no obvious adverse reaction, and the remaining literature does not indicate whether there is any adverse reaction. Conclusion: this study showed that the curative effect of the observation group was better than that of the control group, but the quality of the literature was relatively low because of the addition of the method of strengthening spleen, tonifying the kidney and detoxification of the kidney on the basis of western medicine. There are also large biases, so large, random, multicenter clinical studies should be further developed.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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