益气化瘀法诊治慢性萎缩性胃炎伴低级别上皮内瘤变的临床研究

发布时间：2018-05-15 06:28

本文选题：慢性萎缩性胃炎 + 低级别上皮内瘤变　；参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:通过观察收集导师用以益气化瘀为主要作用的益气活血汤治疗慢性萎缩性胃炎伴低级别上皮内瘤变的经过,总结其治疗经验,并结合自身学习心得试析单教授治疗本病及其兼症的辨证思路和用药特点,以期更好地践行临床。方法:选取符合纳入标准的患者50例,口服单教授经验方"益气活血汤",疗程为6个月,期间伴有Hp阳性患者配合服用"清幽养胃胶囊"。疗程结束后记录并对比分析病例治疗前后胃镜、病理组织报告及临床症状的改变。结果:1.经治疗前后胃镜、病理组织报告比较:萎缩、低级别上皮内瘤变的总有效率分别为66%、88%,治愈率分别为48%、68%。使用统计学分析其治疗前后显示,差异均具备统计学意义(P0.05)。其余如Hp感染等情况均有不同程度的好转。2.治疗前后总体疗效比较:通过尼莫地平法统计总体症状变化情况,临床痊愈17例,显效7例,有效48例,无效2例,显效率为14%,总体有效率为96%。治疗前后总体疗效经配对T检验,前后比较具有统计学差异(P0.05)。余症除Hp感染不具备统计学意义外,均有显著改善。结论:单教授融汇古今,临证用药触类旁通,在贯彻益气化瘀的基础上运用益气活血汤治疗慢性萎缩性胃炎伴低级别上皮内瘤变取得了良好的疗效,其经验值得临床推广和应用。
[Abstract]:Objective: to observe and summarize the experience of treating chronic atrophic gastritis with low grade intraepithelial neoplasia by observing and collecting the course of treating chronic atrophic gastritis with low grade intraepithelial neoplasia, which is mainly used by tutor to invigorate qi and remove blood stasis. Combined with his own learning experience, the author tries to analyze the dialectical thinking and medication characteristics of Professor Dan in the treatment of this disease and its complex disease, in order to better practice the clinical practice. Methods: 50 patients who met the inclusion criteria were taken orally "Yiqi Huoxue decoction" for 6 months, accompanied by HP positive patients with "Qingyou Yangwei capsule". The changes of gastroscopy, histopathological report and clinical symptoms were recorded and analyzed before and after treatment. The result is 1: 1. The total effective rates of atrophy and low grade intraepithelial neoplasia were 66% 88 and 88% respectively. The cure rates were 48% and 68% respectively. The statistical analysis showed that the difference was statistically significant before and after treatment (P 0.05). Others, such as HP infection, improved to some extent. 2. 2. Comparison of the total curative effect before and after treatment: 17 cases were cured, 7 cases were effective, 48 cases were effective, 2 cases were ineffective, the effective rate was 14% and the total effective rate was 96% by Nimodipine method. The total curative effect before and after treatment was compared by paired T test and the difference was statistically significant (P 0.05). With the exception of HP infection, significant improvement was found in all patients. Conclusion: professor Dan syndromes ancient and modern, clinical use of drugs by analogy, on the basis of the implementation of Yiqi Huoxue decoction in the treatment of chronic atrophic gastritis with low grade intraepithelial neoplasia achieved a good effect. Its experience is worth popularizing and applying in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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