鹿瓜多肽注射液治疗骨质疏松症人群特征及联合用药分析

发布时间：2018-05-15 06:34

本文选题：鹿瓜多肽注射液 + 骨质疏松症　；参考：《中药药理与临床》2017年04期

【摘要】：目的:了解真实世界研究鹿瓜多肽注射液(简称鹿瓜多肽)治疗骨质疏松症人群特征和联合用药情况。方法:对全国26家三级甲等医院HIS中使用鹿瓜多肽注射液且主要诊断为骨质疏松症的患者(1159例)用药信息进行分析,采用Apriori算法建立模型,使用Clementine12.0进行关联分析,分析骨质疏松症患者人群特征和鹿瓜多肽联合用药。结果:骨质疏松症患者年龄以46~65岁的中老年人(52.89%)最多;疗程主要集中在1~3 d(899例,83.55%),患者多伴有骨折、高血压病、骨关节炎等疾病;临床联合中成药常与补肾壮骨剂+活血化瘀剂合用(规则支持度26.60%),西药常与镇痛药、抗生素合用(规则支持度34.5%)。结论:鹿瓜多肽注射液是骨科临床常用的复方注射剂,需要进一步结合临床,开展该组合方案的有效性和安全性分析,为临床合理用药提供有效参考。
[Abstract]:Objective: to study the characteristics and combined use of deer melon polypeptide injection in the treatment of osteoporosis in the real world. Methods: the drug information of 1159 patients with Osteoporosis (Osteoporosis) was analyzed in HIS of 26 Grade 3A hospitals in China. Apriori algorithm was used to establish the model and Clementine12.0 was used to carry out correlation analysis. To analyze the characteristics of osteoporosis patients and the combination of deer melon polypeptide. Results: the age of the patients with osteoporosis was 46 ~ 65 years old (52.89), the course of treatment was mainly focused on 899 cases with bone fracture, hypertension, osteoarthritis and other diseases. Clinical combination of traditional Chinese medicine is often combined with tonifying kidney, strengthening bone, activating blood circulation and removing blood stasis (rule support degree 26.60%, western medicine often combined with analgesics and antibiotics) (rule support degree 34.5g). Conclusion: deer melon polypeptide injection is a commonly used compound injection in orthopedic clinic. It needs to be further combined with clinical practice to analyze the efficacy and safety of the combination regimen and to provide an effective reference for rational use of drugs in clinic.
【作者单位】：中国中医科学院中医临床基础医学研究所;中国中医科学院望京医院;中国人民解放军海军总医院;
【基金】：国家"重大新药创制"科技重大专项(2015ZX09501004-001-002) 北京市中医药科技发展专项(JJ2014-53)
【分类号】：R259

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