药艾灸对肿瘤化疗骨髓抑制和生活质量的临床研究

发布时间：2018-05-18 15:04

本文选题：肿瘤 + 化疗　；参考：《南京中医药大学》2016年硕士论文

【摘要】：目的：通过药艾条灸加化疗与单纯化疗在防治肿瘤化疗患者骨髓抑制、生活质量的比较,观察药艾条灸法对肿瘤化疗患者骨髓抑制及功能状态的改善情况,探讨药艾条灸法是否具有减轻化疗对骨髓抑制、提高患者生活质量的作用,为药艾条灸在肿瘤化疗临床的应用提供依据。方法：病人来自江苏省中医院和江苏省中西医结合医院的肿瘤科。将60例符合纳入标准的肿瘤患者根据随机数字表法分为治疗组和对照组[各30例],剔除脱落病例后,治疗组26例,对照组27例。两组病人均用西医常规化疗方案,治疗组在常规化疗方案基础上加用药艾条灸神阙、关元和足三里,每次、每穴灸15分钟,每周灸6次,从患者化疗开始,至下次化疗为1个疗程[约3周],共治疗3个疗程。记录化疗前、三次化疗后的血象、功能状态及化疗后不良反应,比较两组治疗效果的差异。使用SPSS17.0进行观察数据的统计分析。结果：1.骨髓抑制情况：1.白细胞、中性粒细胞：治疗组三次化疗后的白细胞改变与对照组比较都有统计学意义(P0.05)。第一个化疗周期结束后白细胞有所下降,但第二次化疗结束后,P值略有增加。治疗组的中性粒细胞在第一次和第二次化疗后与对照组比较有显著统计学意义。但第3次化疗后的P值大于0.05,无统计学意义。2.血红蛋白：整个治疗组的血红蛋白变化有显著统计学意义[P0.05]。但第一次化疗后比化疗前有所下降,而第二次化疗后的P值较第一化疗后略有升高,第3次化疗后P值比第二次化疗后略有升高。3.血小板：治疗组的血小板变化与对照组比较有统计意义(P0.05)。然而,第2次化疗后的P值较第一化疗后略有升高,第3次化疗后P值比第二次化疗后略有升高。4.红细胞：治疗组的红细胞在第一次化疗后与对照组比较有显著统计学意义(P0.05)。但第2次和3次化疗后的P值大于0.05,无统计学意义。治疗组的RBC与对照组比较,无统计学意义(P值较高)。2.其他副反应：于对照组比较,治疗组的疲劳等副反应发生显著减少,有显著统计学意义(P0.05)。其他副作用,如头晕,口干等在治疗组和对照组间没有明显差异(P0.05)。3.功能状态：治疗组的ZPS评分与化疗前比较明显升高,有显著统计学意义(P0.05)。对照组化疗后比化疗前明显下降,有显著统计学意义(P0.05)。化疗后治疗组患者全身功能状态明显好于对照组,有显著统计学意义(P0.05)结论：1.药艾条灸能减慢白细胞、中性粒细胞、血小板、血红蛋白下降的速度和幅度,减轻化疗对骨髓的抑制、保护血细胞。2.该研究显示药艾条灸对红细胞的作用不明显。3.药艾条灸能提高患者的全身功能状态,提高生存质量。4.药艾条灸是安全有效的方法[研究中无不良事件发生]。
[Abstract]:Objective: to observe the effect of moxibustion plus chemotherapy on the improvement of bone marrow suppression and functional state in patients with tumor chemotherapy by comparing the quality of life and bone marrow suppression with chemotherapy alone. To explore whether moxa moxibustion can alleviate the effect of chemotherapy on bone marrow suppression and improve the quality of life of patients, and provide the basis for clinical application of moxibustion with moxa in tumor chemotherapy. Methods: the patients were from the oncology department of Jiangsu traditional Chinese Medicine Hospital and Jiangsu Integrated Chinese and Western Medicine Hospital. According to the random digital table, 60 patients with tumor were divided into two groups: treatment group (n = 30) and control group (n = 30 each). After removing exfoliation cases, there were 26 cases in treatment group and 27 cases in control group. Two groups of patients were treated with routine western medicine chemotherapy. The treatment group was treated with moxibustion of Shenque, Guan Yuan and Zusanli on the basis of routine chemotherapy. Each time, moxibustion at acupoint for 15 minutes and moxibustion 6 times a week was used in the treatment group, starting with the patient's chemotherapy. To the next chemotherapy for a course [about 3 weeks], a total of 3 courses of treatment. The hemogram, function state and adverse reaction after chemotherapy were recorded before and after three times chemotherapy, and the difference of therapeutic effect between the two groups was compared. SPSS17.0 was used for statistical analysis of observation data. The result is 1: 1. Bone marrow suppression: 1. WBC, neutrophils: the changes of leukocytes in the treatment group after three times chemotherapy were significantly different from those in the control group (P 0.05). At the end of the first chemotherapy cycle, leukocyte decreased, but the P value increased slightly after the second chemotherapy. The neutrophils in the treatment group were significantly higher than those in the control group after the first and second chemotherapy. But after the third chemotherapy, P value was more than 0.05, no statistical significance. 2. Hemoglobin: the change of hemoglobin in the whole treatment group was statistically significant [P0.05]. However, after the first chemotherapy, the P value after the second chemotherapy was slightly higher than that after the first chemotherapy, and the P value after the third chemotherapy was slightly higher than that after the second chemotherapy. Platelet: compared with the control group, the changes of platelet in the treatment group were statistically significant (P 0.05). However, the P value after the second chemotherapy was slightly higher than that after the first chemotherapy, and the P value after the third chemotherapy was slightly higher than that after the second chemotherapy. Red blood cells: red blood cells in the treatment group after the first chemotherapy compared with the control group has significant statistical significance (P 0.05). But after the second and third chemotherapy, the P value was more than 0.05, there was no statistical significance. The RBC of the treatment group was higher than that of the control group (P < 0.05). Other side effects: compared with the control group, fatigue and other side effects in the treatment group were significantly reduced, with significant statistical significance (P 0.05). Other side effects, such as dizziness and dry mouth, had no significant difference between the treatment group and the control group (P 0.05). Functional status: the ZPS score of the treatment group was significantly higher than that before chemotherapy (P 0.05). In the control group, it was significantly lower after chemotherapy than that before chemotherapy, with significant statistical significance (P 0.05). The systemic function of the patients in the treatment group after chemotherapy was significantly better than that in the control group (P 0.05). Moxibustion could slow down the decrease of leukocyte, neutrophil, platelet and hemoglobin, reduce the inhibition of chemotherapy on bone marrow and protect blood cell. The study showed that moxibustion of medicated moxibustion had no obvious effect on erythrocyte. Medicinal moxibustion can improve the whole body function of patients, improve the quality of life. 4. Herbal moxibustion is a safe and effective method [there are no adverse events in the study].
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.5

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