菝葜妇炎泡腾栓止痒生肌收敛止血作用研究

发布时间：2018-05-19 07:13

本文选题：菝葜妇炎泡腾栓 + 止痒　；参考：《中药药理与临床》2017年03期

【摘要】：目的:研究菝葜妇炎泡腾栓是否有止痒、生肌祛腐及收敛止血的作用,从而客观评价其止痒、祛腐生肌、收敛止血的功效。方法:以菝葜妇炎泡腾栓3种不同剂量用雌性豚鼠与小鼠造模,通过止痒、促进创口愈合、促进烫伤溃疡愈合及止血试验来客观评价其药效学的治疗作用。结果:菝葜妇炎泡腾栓111.6、55.8mg生药/kg剂量均具有显著止痒作用,可使引起豚鼠瘙痒的磷酸组织胺总用量(致痒阈)显著增加;223.3mg生药/kg剂量具有显著促进伤口愈合作用,降低创口损伤程度等级;111.6、55.8mg生药/kg剂量均具有显著促进烫伤溃疡面愈合作用,使烫伤溃疡面痊愈时间分别缩短17.32%和15.64%;223.3、111.6、55.8mg生药/kg 3种剂量均可使小鼠的凝血时间分别缩短40.78%、30.87%和24.27%,这种止血作用对阴道炎的阴道壁黏膜出血,以及宫颈糜烂时所引起的出血症状均可发挥治疗作用。结论:菝葜妇炎泡腾栓有显著的止痒生肌收敛止血作用。
[Abstract]:Objective: to study the effects of Smilax china phlogistic effervescent suppository (Smilax china) on relieving itching, removing rot and astringent bleeding, so as to evaluate objectively its effect of stopping itching, removing rot and growing muscle and astringent hemostasis. Methods: three different dosages of Smilax china luteus effervescent suppository were used to model female guinea pigs and mice. The pharmacodynamics of Smilax china simplex suppository was evaluated objectively by relieving itching, promoting wound healing, promoting the healing of scalded ulcer and hemostatic test. Results: Smilax china lactin effervescent suppository (111.6 mg / kg) had a significant antipruritic effect, and the total dose of histamine phosphate (itching threshold), which caused itching in guinea pigs, was significantly increased by 223.3 mg / kg of crude drug / kg, which could significantly promote wound healing. The reduction of wound injury grade (111.6 mg / kg) could significantly promote the healing of scalded ulcer surface, and the dose of 111.6 mg / kg could significantly promote the healing of scalded ulcer. The healing time of scalded ulcer surface was shortened by 17.32% and 15.64 mg / kg, respectively. The coagulation time of mice was reduced by 40.78% and 24.27%, respectively. The hemostatic effect on vaginal wall mucous membrane bleeding of vaginitis could be reduced by 40.78% and 24.27%, respectively. And cervical erosion caused by bleeding symptoms can play a therapeutic role. Conclusion: Smilax china rhinitis effervescent suppository has the effect of stopping itching muscle convergence and hemostasis.
【作者单位】：贵阳护理职业学院;安徽中医药高等专科学校;贵阳中医学院;国家苗药工程技术研究中心;
【基金】：贵州省中药现代化科技创新项目(黔科合农字[2006]5011号) 贵州省经贸委(06033)
【分类号】：R29

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