温胆汤加味治疗马来西亚痰热内扰型失眠的临床研究

发布时间：2018-05-20 19:02

  本文选题：失眠 + 马来西亚　； 参考：《福建中医药大学》2016年博士论文

【摘要】：目的：通过温胆汤加味治疗马来西亚地区痰热内扰型失眠的临床观察,评价其临床效应并探讨其临床机制,为马来西亚痰热内扰型失眠的治疗提供安全、有效的方法。方法：选择2015年4月至2016年3月在马来西亚霹雳怡保仁爱医院与霹雳金宝德安堂药行门诊就诊,符合课题纳入、排除标准的120例痰热内扰型失眠患者为研究对象,予温胆汤加味科学浓缩中药颗粒剂,连续治疗4周,治疗后观察患者的临床疗效,比较治疗前后中医证候学积分、匹兹堡睡眠质量指数量表(PSQI)积分的差异性,评价调胆和胃,清热化痰,健脾安神法对失眠病人的治疗作用。结果：本次研究共搜集120例符合纳入、排除标准的病例,其中男性28例,占23.3%,女性92例,占76.6%,平均年龄45.75±10.72岁。治疗后痊愈8例、显效62例、有效42例、无效8例,所占比率分别为6.66%、51.66%、35%及6.66%,总有效率达93.3%。匹兹堡睡眠质量指数量表(PSQI)积分比较：治疗前积分17.40±2.509,治疗后积分5.17±3.206,治疗前后PSQI分数采用配对Z检验,有统计学意义(P0.05),即治疗后较治疗前PSQI评分降低。中医症候学积分比较：治疗前积分23.63±3.970,治疗后积分6.50±4.605,治疗前后采用配对Z检验,有统计学意义(P0.05),即治疗后较治疗前中医症候学评分降低。结论：通过本研究得出,温胆汤加味治疗马来西亚地区痰热内扰型失眠症状明显改善,睡眠治疗明显提高,临床疗效显著。“调胆和胃,清热化痰,健脾安神”法是治疗痰热内扰失眠的有效法则。
[Abstract]:Objective: To evaluate the clinical effects and clinical mechanism of Wendan Decoction in the treatment of phlegm heat internal disturbance in Malaysia area, and to explore its clinical mechanism, and provide a safe and effective method for the treatment of insomnia in Malaysia's phlegm heat internal disturbance. Methods: from April 2015 to March 2016, Ipoh benevolent hospital and thunderbolt in Malaysia were selected. 120 cases of insomnia patients with phlegm heat internal disturbance were taken as the research object, and the clinical curative effect was observed after treatment for 4 weeks, and the TCM syndrome scores before and after treatment were compared with the Pittsburgh sleep quality index scale (PSQI). The difference of the score, evaluate the therapeutic effect of gall and stomach, heat clearing and phlegm, invigorating spleen and Anshen on insomnia patients. Results: 120 cases were collected in this study, including 28 cases of male, 23.3%, 92 women, 76.6% and 45.75 10.72 years old. After treatment, 8 cases were cured, 62 cases were markedly effective, 42 cases effective, 8 cases null and void, The ratio was 6.66%, 51.66%, 35% and 6.66%, and the total effective rate was compared with the 93.3%. Pittsburgh sleep quality index (PSQI) score: 17.40 + 2.509 before treatment and 5.17 + 3.206 after treatment. The PSQI score before and after treatment was statistically significant (P0.05), that is, lower than the pre treatment PSQI score after treatment. Integral comparison: the score was 23.63 + 3.970 before treatment and 6.50 + 4.605 after treatment. The matched Z test before and after treatment had statistical significance (P0.05), that is to say, the score of TCM syndrome was lower than before treatment. Conclusion: through this study, it is concluded that the symptoms of phlegm heat internal disturbance in Malaysia area are obviously improved and sleep treatment is treated by this study. The method of regulating gallbladder and stomach, clearing away heat and resolving phlegm, strengthening spleen and tranquilizing mind are effective rules for treating insomnia caused by phlegm heat.
【学位授予单位】：福建中医药大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R256.23
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本文编号：1915857