加味香砂六君子汤治疗慢性心力衰竭的临床研究

发布时间：2018-05-20 19:09

本文选题：慢性心力衰竭 + 加味香砂六君子汤　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：通过观察加味香砂六君子汤治疗慢性心力衰竭的临床疗效,为慢性心力衰竭的治疗提供新的思维方法。方法：依据中医以及西医的诊断及排除标准,从我院(成都中医药大学附属医院)急诊科住院部及门诊随机选择64例受试者,其中治疗组32例,对照组32例,对照组采用西医基础治疗,治疗组在西医基础治疗上予以加味香砂六君子汤口服,4周后观察治疗效果。疗程结束后观察两组治疗效果,应用统计软件SPSS 21.0进行统计分析,P0.05有临床意义,并且进行安全性和依从性评价。结果：1、两组患者心衰总疗效比较,治疗组总有效率80%,对照组总有效率56.7%,治疗组明显优于对照组(P0.05)。2、两组患者治疗后中医症状总积分比较,两组治疗后差异有统计学意义(P0.05),治疗组优于对照组。治疗组在改善心悸、恶心呕吐、食欲不振、腹胀、出汗等方面,治疗组的疗效明显优于对照组(P0.01),改善气短、大便不畅、疲乏无力等方面,治疗组疗效优于对照组(P0.05),两组在改善胸闷胸痛、水肿、畏寒肢冷、咳嗽咯痰、尿少两组无明显差异(P0.05)3、治疗组在改善心功能、脑钠肽、6分钟步行实验等方面,疗效均优于对照组(P0.05),心脏彩超指标,两组比较无统计学意义(P0.05)。4、两组在用药前后安全指标没有发现明显异常。结论：加味香砂六君子汤治疗慢性心力衰竭与西药常规治疗有协同作用,不仅可以提高运动耐量,而且在增强疗效改善心功能、中医症状上有显著效果,并且安全可靠,但对改善心脏结构等方面无明显疗效,此试验表明中医辨证论治在个体化治疗慢性心力衰竭中有重要作用。
[Abstract]:Objective: to observe the clinical effect of Jiawei Xiangsha Liujunzi decoction on chronic heart failure and to provide a new way of thinking for the treatment of chronic heart failure. Methods: according to the criteria of diagnosis and exclusion of traditional Chinese medicine and western medicine, 64 subjects were randomly selected from the emergency department and outpatient department of our hospital (affiliated Hospital of Chengdu University of traditional Chinese Medicine), including the treatment group (32 cases) and the control group (32 cases). The control group was treated with western medicine, and the treatment group was treated with Xiangsha Liujunzi decoction for 4 weeks. The therapeutic effect was observed after the course of treatment. The statistical software SPSS 21.0 was used for statistical analysis (P0.05), and the safety and compliance were evaluated. Results compared with the two groups, the total effective rate of the treatment group was 80%, the total effective rate of the control group was 56.7%, the treatment group was obviously superior to the control group (P 0.05) .2.The total score of TCM symptoms after treatment was compared between the two groups. The difference between the two groups after treatment was statistically significant (P 0.05), and the treatment group was superior to the control group. In the treatment group, the palpitations, nausea and vomiting, loss of appetite, abdominal distension and sweating were improved. The curative effect of the treatment group was better than that of the control group (P 0.01). The curative effect of the treatment group was better than that of the control group (P 0.05). There was no significant difference between the two groups in improving chest tightness, chest pain, edema, cold chills, cough and sputum, and less urine (P 0.05). The treatment group improved cardiac function and brain natriuretic peptide for 6 minutes walking experiment, etc. The curative effect was better than that of the control group (P 0.05), cardiac color Doppler imaging, and there was no significant difference between the two groups in the safety index before and after treatment. Conclusion: Jiawei Xiangsha Liujunzi decoction has synergistic effect on chronic heart failure and routine treatment of western medicine. It can not only improve exercise tolerance, but also improve cardiac function. However, there is no obvious effect on improving heart structure. This experiment shows that TCM syndrome differentiation plays an important role in individualized treatment of chronic heart failure.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】