扶正健儿膏方治疗非急性期小儿反复呼吸道感染

发布时间：2018-05-21 18:38

本文选题：反复呼吸道感染 + 扶正健儿膏方　；参考：《中国实验方剂学杂志》2017年12期

【摘要】：目的:观察扶正健儿膏方对小儿反复呼吸道感染(RRTI)非急性期患者病情的控制作用及对T淋巴细胞亚群、免疫球蛋白和Th1/Th2细胞因子的影响。方法:将160例RRTI非急性期患儿,采用SAS软件生成的数字表法,按就诊先后顺序随机分为对照组和观察组。对照组采用匹多莫德口服溶液,400 mg/次,1次/d;葡萄糖酸锌口服溶液,3~6岁,5 m L/次,2次/d;7~12岁,7.5 m L/次,2次/d;适量补充维生素C和A。观察组采用扶正健儿膏方,3~6岁,5 m L/次,温水冲服,晨起空腹,3次/d;7~12岁,10 m L/次,2次/d。两组疗程均连续服用24周,疗程结束均进行24周的随访。记录48周内呼吸道感染发作次数,每次发作的持续时间,每次发病病种;检测治疗前后血清免疫球蛋白G(Ig G),免疫球蛋白A(Ig A),免疫球蛋白M(Ig M)和T淋巴细胞亚群(CD3~+,CD4~+,CD8~+,CD4~+/CD8~+)水平,检测治疗前后白细胞介素-2(IL-2),干扰素-γ(FN-γ),白细胞介素-4(IL-4),白细胞介素-5(IL-5)水平。结果:观察组临床疗效痊愈率为52.7%高于对照组的32.88%(χ~2=5.898,P0.05);观察组中医证候疗效总有效率为94.59%,对照组为78.08%,观察组高于对照组(χ~2=8.524,P0.01);在48周的观察期内,观察组平均发作次数,即反复上呼吸道感染、反复气管支气管炎和反复肺炎的发作次数均少于对照组,平均发病病程也短于对照组(P0.01);治疗后观察组IgG,IgA,IgM水平高于对照组(P0.01);治疗后观察组CD3~+,CD4~+和CD4~+/CD8~+均高于对照组,CD8~+低于对照组(P0.01);治疗后观察组血清IL-2和IFN-γ水平均高于对照组,IL-4和IL-5水平均低于对照组(P0.01)。结论:扶正健儿膏方治疗反复呼吸道感染患儿,能提高患者的免疫功能,调节Th1/Th2平衡,增加患儿机体免疫能力,从而减少呼吸道感染发生频率,缩短发作病程,提高临床疗效。
[Abstract]:Objective: to observe the control effect of Fuzheng Jianer ointment on non-acute stage patients with recurrent respiratory tract infection (RRTI) and its effect on T lymphocyte subsets, immunoglobulin and Th1/Th2 cytokines. Methods: 160 cases of non-acute RRTI children were randomly divided into control group and observation group by digital table method generated by SAS software. The control group was treated with pidomod oral solution for 400 mg/ d, zinc gluconate oral solution for 6 years old / 5 mL / twice / d, 12 years old for 7 years and 7.5mL / d for 2 times / d, and vitamin C and A. The observation group was treated with Fuzheng Jianer ointment at the age of 3 to 6 years old or 5 mL / time, warm water was taken, and every 10 mL / 2 / d of 3 / d / 712 years old from the morning. The two groups were treated continuously for 24 weeks and followed up for 24 weeks at the end of the course. The number of episodes of respiratory tract infection within 48 weeks, the duration of each attack, and the disease types of each attack were recorded. The levels of serum immunoglobulin (G(Ig), immunoglobulin A (Ig), immunoglobulin M(Ig (M(Ig) and T lymphocyte subsets (CD3 ~ + CD4 ~ + CD8 ~ / CD8 ~) were measured before and after treatment, and the levels of interleukin-2 (IL-2FN- 纬), interleukin-4 (IL-4), interleukin-5 (IL-5) were detected before and after treatment. Results: the cure rate of the observation group was 52.7% higher than that of the control group (32.88%) (蠂 ~ 2 + 5.898) P0.05.The total effective rate of TCM syndromes in the observation group was 94.59%, and that in the control group was 78.08%, which was higher in the observation group than that in the control group (蠂 ~ (2) 2) 8.524 (P0.01); during the observation period of 48 weeks, the average number of seizures in the observation group was higher than that in the control group. That is, repeated upper respiratory tract infections, recurrent bronchitis and repeated pneumonia were less frequent than those in the control group. The mean course of disease was also shorter than that of the control group (P 0.01), the level of IgGG IL-2 IgM in the observation group was higher than that in the control group after treatment, the levels of CD3 ~ + CD4 ~ and CD4 ~ / CD8 ~ were higher in the observation group than in the control group, and the levels of serum IL-2 and IFN- 纬 in the observation group were higher than those in the control group after treatment. The levels of IL-4 and IL-5 in group A were lower than those in control group (P 0.01). Conclusion: Fuzheng Jianer ointment can improve the immune function of children with recurrent respiratory tract infection, regulate the balance of Th1/Th2, increase the immune ability of children, reduce the frequency of respiratory tract infection, shorten the course of attack and improve the clinical efficacy.
【作者单位】：重庆市中医院;
【基金】：重庆市卫生局中医药科技项目(2013-54)
【分类号】：R272

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