更年期潮热的时间节律与更年期综合征中医证型分布相关性研究

发布时间：2018-05-23 07:26

本文选题：更年期综合征 + 潮热　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：本研究通过探索更年期潮热发作及加重的时间节律性,分析其与更年期综合征中医证型之间的相关性,以期从时间节律的角度为更年期潮热患者的中医诊疗提供一种辨证思路,以及为择时给药的临床应用提供理论参考依据。方法：通过查阅相关文献及临床观察,参照导师经验及专家意见设计调查表,共设定7个时间项目,分别为不定时项、全夜项、全日项、前半夜、后半夜、上半日、下半日,收集2015年2月-2016年2月符合本试验纳入标准的患者共369例,使用EXCEL表建立信息数据库,运用SPSS 17.0统计软件包,对数据进行频数分析、聚类分析、卡方检验等,最后得出结论。结果：(1)本研究共纳入更年期潮热患者369例,潮热发作及加重有定时者共314例,占总百分比的85%,无定时者共55例,占总百分比的15%,差异有统计学意义(p0.05)；(2)对369例患者的中医症候进行统计学聚类分析,总结出七个更年期综合征的中医证型,分别是肾阴虚证84例,肾阳虚证43例,肾阴阳俱虚证48例,心肾不交证47例,肾虚血瘀证40例,阴虚肝旺证58例,肝郁血热证49例。(3)潮热发作及加重于夜间者共73例,以肾阴虚证最多见,共计42例；潮热发作及加重于白天者共53例,以肝郁血热证最多见,共计19例：潮热发作及加重于上半日共37例,以肾阳虚证最多见,共计14例；潮热发作及加重于下半日者53例,以心肾不交证最多见,共计18例；潮热发作及加重于前半夜者共56例,以肾虚血瘀证最多见,共计19例；潮热发作及加重于后半夜者共42例,以阴虚肝旺证最多见,共计18例；各时间组中医证型构成比比较,差异均有统计学意义(p0.01)；(4)肾阴虚证更年期综合征患者共84例,潮热发作及加重于夜间者最多见,共计42例；肾阳虚证更年期综合征患者共43例,潮热发作及加重于上半日者最多见,共计14例；心肾不交证更年期综合征患者共47例,潮热发作及加重于下半日者最多见,共计18例；肾虚血瘀证更年期综合征患者共40例,潮热发作及加重于前半夜者最多见,共计19例；阴虚肝旺证更年期综合征患者共58例,潮热发作及加重于后半夜者多见,共计18例；肝郁血热证更年期综合征患者共49例,潮热发作及加重于白天者最多见,共计19例；各中医证型组潮热发作及加重时间构成比比较,差异均有统计学意义(p0.05)。结论：更年期潮热发作及加重具有时间节律性,更年期潮热发作及加重的时间与更年期综合征中医证型相关。
[Abstract]:Objective: to explore the temporal rhythm of climacteric hot flashes and to analyze its correlation with the TCM syndromes of climacteric syndrome. In order to provide a dialectical thinking for the diagnosis and treatment of climacteric hot flashes from the point of view of time rhythm, as well as to provide a theoretical reference for the clinical application of drug timing. Methods: according to the related literature and clinical observation, the questionnaire was designed according to the tutor's experience and expert's opinion. Seven time items were set up, which were unscheduled item, whole night item, whole day item, the first midnight, the later midnight, the first half, the second half of the day, the first half of the night, the second half of the day. From February 2015 to February 2016, 369 patients who met the criteria of this experiment were collected. The information database was established by using EXCEL table, and the frequency analysis, cluster analysis and chi-square test were carried out by using SPSS 17.0 statistical software package. Finally, the conclusion was drawn. Results (1) in this study, 369 climacteric hot flashes were included. There were 314 cases with regular onset and exacerbation of hot flashes, accounting for 85% of the total, and 55 cases without timing. 15% of the total, the difference was statistically significant (p 0.05) the TCM syndromes of 369 patients were analyzed statistically, and the seven TCM syndromes of climacteric syndrome were summed up. They were kidney yin deficiency syndrome 84 cases and kidney yang deficiency syndrome 43 cases. There were 48 cases of kidney yin and yang deficiency syndrome, 47 cases of heart and kidney disconnection syndrome, 40 cases of kidney deficiency and blood stasis syndrome, 58 cases of yin deficiency and liver flourishing syndrome, 49 cases of liver stagnation and blood heat syndrome. There were 53 cases of hot flashes and exacerbations during the day, the most common of which were liver depression and blood heat syndrome (19 cases), 37 cases of hot flashes and aggravation in the first half day, 14 cases of deficiency of kidney-yang syndrome, 53 cases of hot flashes attack and aggravation in the second half of the day. The most common cases were heart-kidney syndrome (18 cases), 56 cases of hot flashes and exacerbations in the first half of the night, 19 cases of kidney deficiency and blood stasis syndrome, 42 cases of hot flashes and aggravation in the late midnight, 18 cases of liver flourishing syndrome due to yin deficiency. There were 84 cases of climacteric syndrome of kidney yin deficiency syndrome, 42 cases of hot flashes and exacerbation at night, 43 cases of climacteric syndrome of deficiency of kidney-yang syndrome. The onset and aggravation of hot flashes occurred most frequently in the first half of the day, in a total of 14 cases; in 47 cases of climacteric syndrome of heart and kidney disconnection syndrome, 18 cases of hot flashes attack and aggravation in the second half of the day; and 40 cases of climacteric syndrome of deficiency of kidney and blood stasis syndrome, The onset and aggravation of hot flashes were most common in the first half of the night (19 cases in total), 58 cases in the climacteric syndrome of yin deficiency and liver hyperactivity syndrome, 18 cases in the hot flashes attack and aggravation in the late midnight, 49 cases in the climacteric syndrome of liver stagnation and blood heat syndrome, The onset and aggravation of hot flashes were most common in the daytime (19 cases), and there were significant differences in the proportion of the onset and exacerbation time of hot flashes in each TCM syndrome group (P 0.05). Conclusion: the onset and aggravation of menopausal hot flashes have temporal rhythm. The time of onset and aggravation of climacteric hot flashes is related to the TCM syndrome type of climacteric syndrome.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.116

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