调经活血胶囊治疗寒凝血瘀型原发性痛经有效性的临床研究

发布时间：2018-05-24 18:02

本文选题：原发性痛经 + 寒凝血瘀型　；参考：《南京中医药大学》2016年硕士论文

【摘要】：目的：观察调经活血胶囊治疗寒凝血瘀型原发性痛经的临床疗效。方法：本临床研究采用随机、平行对照的研究方法。将60例诊断为寒凝血瘀型原发性痛经的患者,随机分为两组,每组各30例,分别为治疗组(调经活血胶囊)和对照组(痛经宝颗粒)。服药3个月经周期后,观察两组患者治疗前后中医证候评分,疼痛程度评价和治疗前后血清PGF2a的变化情况,并统计分析,评价其临床疗效性。停药3个月经周期后,观察两组患者的中医证候评分,疼痛程度评价,并统计分析,评价其远期疗效。结果：1.治疗组与对照组在年龄、病程、治疗前的疼痛程度评价及中医证候评分等方面的比较,均无统计学差异(P0.05),具有可比性。2.疼痛程度评价：治疗3个月经周期后,治疗组总有效率为90.00%,对照组总有效率为93.33%,比较两组组间疗效,无统计学差异(P0.05)。比较治疗前后两组患者的疼痛程度评价,均较治疗前有显著性差异(P0.01)；治疗后两组组间比较,无统计学差异(P0.05)。3.中医证候综合疗效评价分析：治疗3个月经周期后,治疗组总有效率为93.33%,对照组总有效率为90.00%,比较两组组间疗效,无统计学差异(P0.05)。比较治疗前后两组患者中医证候综合疗效评分,均较治疗前有显著性差异(P0.01)；治疗后两组组间比较,无统计学差异(P0.05)。4.两组部分患者治疗前血清PGF2a水平比较,无统计学差异(P0.05)。治疗后两组患者血清PGF2a水平与治疗前比较,均有显著性差异(P0.01),两组组间疗效比较,无统计学差异(P0.05)。5.停药3个月经周期后疼痛程度评价及中医证候总积分变化情况：两组与治疗前比较均有显著性差异(P0.01)。两组与治疗3个月经周期结束后比较,具有显著性差异(P0.01)。6.在临床观察中,调经活血胶囊治疗原发性痛经患者用药期间未发现明显不良反应。结论：调经活血胶囊能有效减轻寒凝血瘀型原发性痛经患者的疼痛程度、改善中医证候评分,缓解女性经期疼痛及各种不适症状,且无明显不良反应。调经活血胶囊降低了患者血清PGF2α水平,可能为其临床治疗的作用机理。
[Abstract]:Objective: to observe the clinical effect of Tiaojing Huoxue capsule on primary dysmenorrhea of cold coagulation and blood stasis. Methods: a randomized, parallel controlled study was used in this clinical study. Sixty patients with primary dysmenorrhea of cold coagulation and blood stasis type were randomly divided into two groups: treatment group (Tiaojing Huoxue capsule) and control group (Tongjingbao granule). After taking medicine for 3 menstrual cycles, the TCM syndromes score, pain degree evaluation and changes of serum PGF2a before and after treatment were observed, and statistical analysis was made to evaluate the clinical efficacy of the two groups. After three menstrual cycles, the TCM syndromes score, pain degree evaluation and statistical analysis were observed to evaluate the long-term efficacy of the two groups. The result is 1: 1. There was no statistical difference between the treatment group and the control group in age, course of disease, pain degree evaluation before treatment and TCM syndrome score. Pain evaluation: after 3 menstrual cycles, the total effective rate of the treatment group was 90.00g and the total effective rate of the control group was 93.330.There was no statistical difference between the two groups (P 0.05). There was significant difference in pain degree between the two groups before and after treatment (P 0.01), but there was no significant difference between the two groups after treatment. Evaluation of Syndromes of TCM Syndromes: after 3 menstrual cycles, the total effective rate of the treatment group was 93.33, and the total effective rate of the control group was 90.00.There was no statistical difference between the two groups (P 0.05). There was a significant difference between the two groups before and after treatment compared with before and after treatment, and there was no significant difference between the two groups after treatment (P 0.05. 4). There was no significant difference in serum PGF2a levels between the two groups before treatment (P 0.05). There was significant difference in serum PGF2a level between the two groups after treatment and before treatment (P 0.01). There was no significant difference in the curative effect between the two groups (P 0.05). Evaluation of pain degree and change of total integral of TCM syndromes after three menstrual cycles: there were significant differences between the two groups and before treatment (P 0.01). There was a significant difference between the two groups after the end of three menstrual cycles. In clinical observation, there was no obvious adverse reaction during the treatment of primary dysmenorrhea with Tiaojing Huoxue capsule. Conclusion: Tiaojing Huoxue capsule can effectively alleviate the pain degree of primary dysmenorrhea patients with cold coagulation and blood stasis, improve the TCM syndrome score, relieve the pain and all kinds of uncomfortable symptoms of female menstrual period, and have no obvious adverse reactions. Tiaojing Huoxue capsule decreased the level of serum PGF2 伪, which may be the mechanism of clinical treatment.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.113

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