散痹汤加减治疗寒湿痹阻型腰椎间盘突出症临床观察

发布时间：2018-05-25 02:01

本文选题：散痹汤加减 + 依托考昔片　；参考：《中国实验方剂学杂志》2017年15期

【摘要】：目的:观察散痹汤加减治疗寒湿痹阻型腰椎间盘突出症的疗效及安全性。方法:将192例符合条件的患者随机分为中药组、西药组和中西药组,各64例。中药组给予散痹汤加减治疗,西药组给予依托考昔片治疗,中西药组同时给予散痹汤加减结合依托考昔片治疗,疗程均为28 d。观察各组治疗前后改良日本骨科协会腰疼痛评分量表(M-JOA),Oswestry功能障碍指数问卷评分量表(ODI),视觉模拟评分法(VAS)和中医辨证寒湿痹阻型腰椎间盘突出症中医证候评分;检测治疗前后检测各组血清肿瘤坏死因子-α(TNF-α),白细胞介素-1β(1L-1β),C-反应蛋白(CRP)和超氧化物歧化酶(SOD)的变化;比较各组有效率和不良事件发生率。结果:治疗后中西药组总有效率95.1%,高于中药组的79.4%和西药组的82.3%(P0.05);中药组与西药组比较无明显差异;中西药组和中药组中医证候评分较西药组改善更为明显(P0.05);其他临床症状中西药组改善较中药组和西药组更为明显(P0.05);不良事件发生率中药组低于西药组和中西药。结论:散痹汤加减治疗寒湿痹阻型腰椎间盘突出症的疗效与西药依托考昔片无明显差异,具有有效性,且不良事件的发生率较依托考昔片低;散痹汤加减结合依托考昔片治疗寒湿痹阻型腰椎间盘突出症具有协同增效作用,疗效优于单用散痹汤加减和依托考昔片。
[Abstract]:Objective: to observe the efficacy and safety of Sanbi decoction in the treatment of cold and dampness obstruction lumbar intervertebral disc herniation. Methods: 192 patients were randomly divided into Chinese medicine group, western medicine group and western medicine group with 64 cases each. The traditional Chinese medicine group was treated with Sanbi decoction, the western medicine group was treated with etacoxib, and the Chinese and western medicine group was treated with Sanbi decoction combined with traditional Chinese medicine. The course of treatment was 28 days. Before and after treatment, the modified Japanese Orthopedic Association Lumbar pain scale (MJOAA) and Oswestry dysfunction Index (Oswestry) scale, visual analogue score (VASS) and TCM syndrome score of syndrome differentiation of cold dampness obstruction type lumbar intervertebral disc herniation (TCM) were observed. Before and after treatment, the serum levels of TNF- 伪 TNF- 伪, IL-1- 尾 -1- 尾 -C- reactive protein (CRP) and superoxide dismutase (SOD) were measured, and the effective rate and incidence of adverse events in each group were compared. Results: the total effective rate of Chinese and western medicine group was 95.1%, which was higher than that of Chinese medicine group (79.4%) and western medicine group (82.3%), but there was no significant difference between traditional Chinese medicine group and western medicine group. The scores of TCM syndromes in traditional Chinese medicine group and traditional Chinese medicine group were improved more obviously than that in western medicine group, other clinical symptoms in traditional Chinese medicine group and western medicine group were improved more obviously than that in traditional Chinese medicine group and western medicine group, and the incidence of adverse events in traditional Chinese medicine group was lower than that in western medicine group and western medicine group. Conclusion: the curative effect of Sanbi decoction on the treatment of cold dampness obstruction type lumbar intervertebral disc herniation is not significantly different from that of western medicine, and it is effective, and the incidence of adverse events is lower than that of Tongcaoxi tablet. Sanbi decoction combined with relying Coxie tablet in the treatment of cold dampness obstruction of lumbar intervertebral disc herniation has synergistic effect, the curative effect is better than the single use of Sanbi decoction and relying Coxie tablet.
【作者单位】：河南省中医院;郑州市第九人民医院;郑州市中医院;
【基金】：河南省科技攻关计划项目(17210231322)
【分类号】：R274.9

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