参榆灌肠液治疗活动期直肠型溃疡性结肠炎的临床疗效观察

发布时间：2018-05-25 14:22

本文选题：溃疡性结肠炎 + 参榆灌肠液　；参考：《南京中医药大学》2017年硕士论文

【摘要】：目的:观察和评价参榆灌肠液治疗轻、中度活动期直肠型溃疡性结肠炎的临床疗效及安全性。方法:将60例轻、中度活动期直肠型溃疡性结肠炎患者随机分为治疗组和对照组,每组各30例。治疗组予参榆灌肠液灌肠,对照组予美沙拉嗪栓塞肛。以3个月为一疗程。治疗结束后通过SPSS软件统计分析,比较两组临床疗效(临床有效率、临床缓解率、内镜应答率、黏膜愈合率)、中医证候疗效及主要症状改善情况,并监测用药安全性。结果:两组在临床有效率、临床缓解率、内镜应答率、黏膜愈合率方面无明显统计学差异(P0.05)。中药灌肠组的中医证候疗效优于美沙拉嗪栓剂组(P0.05),中药灌肠组患者腹痛、里急后重症状的消失率(81.5%、86.7%)高于美沙拉嗪栓剂组(51.9%、63.3%),差异具有统计学意义(P0.05)。中药灌肠组患者脓血便及腹泻症状的消失率与美沙拉嗪栓剂组比较,差异没有统计学意义(P0.05)。两组用药期间均无不良反应发生。结论:参榆灌肠液治疗轻、中度活动期直肠型UC安全有效,在改善部分症状方面优于美沙拉嗪栓剂组。
[Abstract]:Objective: to observe and evaluate the clinical efficacy and safety of Shenyu enema in the treatment of mild and moderate active rectal ulcerative colitis. Methods: 60 patients with mild and moderate active rectal ulcerative colitis were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was enemized with shenyu enema and the control group was embolized with mesalazine. Take 3 months as a course of treatment. After treatment, the clinical efficacy (clinical effective rate, clinical remission rate, endoscopic response rate, mucosal healing rate, TCM syndromes and main symptoms improvement) were compared between the two groups by SPSS software statistical analysis, and the safety of medication was monitored. Results: there was no significant difference in clinical effective rate, clinical remission rate, endoscopic response rate and mucosal healing rate between the two groups (P 0.05). The curative effect of TCM syndrome in the Chinese medicine enema group was better than that in the mesalazine suppository group (P 0.05), and the disappearance rate of abdominal pain and severe symptoms in the Chinese medicine enema group was higher than that in the mesalazine suppository group (P 0.055.The difference was statistically significant. There was no significant difference in the disappearance rate of purulent stool and diarrhea symptoms between the Chinese medicine enema group and the mesalazine suppository group (P 0.05). There were no adverse reactions in both groups. Conclusion: Shenyu enema is safe and effective in the treatment of mild and moderate active rectal UC, and it is superior to mesalazine suppository in improving some symptoms.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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