益气养阴润肠汤治疗气阴两虚型老年功能性便秘的临床研究

发布时间：2018-05-25 15:05

本文选题：益气养阴润肠汤 + 老年功能性便秘　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的:通过与聚乙二醇4000散剂(商品名:福松)做对照,观察益气养阴润肠汤对老年功能性便秘患者的临床症状改善情况,研究其治疗效果,初步探讨其治疗机制,由此进一步评价益气养阴润肠汤的安全性、有效性及远期疗效性,进而为临床应用提供有力的科学依据。方法:选择2015年1月至2016年1月就诊于河南中医药大学第二附属医院肛肠科,符合气阴两虚型老年便秘患者60例,按每个病人就诊时生成的就诊号,制成EXCEL表,运用随机数字表分组法,分为治疗组30例和对照组30例。治疗组运用益气养阴润肠汤,对照组运用福松。两组均连续治疗一个月,治疗期间详细记录两组患者临床症状变化情况及有无不良反应。治疗结束后,对两组治疗前后临床总疗效、临床症状评分变化情况及停药2个月后的复发情况,采用SPSS19.0统计软件,经统计学处理来评估分析。结果:(1)在改善临床总疗效方面:治疗组总有效率为93.33%,总有效率为73.33%,经统计学分析,两组患者总有效率比较差异明显(P0.05),具有统计学意义,说明两组在改善临床总疗效方面,治疗组优于对照组。(2)在改善临床总症状积分方面:两组患者分别治疗后,临床总症状积分与治疗前比较,均有显著性差异(P0.05),说明两组均能改善老年功能性便秘患者的临床总症状;治疗后两组总症状积分差值比较(P0.05),具有统计学意义,说明治疗组在改善临床总症状方面明显优于对照组。(3)在改善临床主要症状积分方面:两组患者分别治疗后,排便间隔时间、排便时间、大便性状、排便困难程度积分与治疗前比较,均有显著性差异(P0.05),说明两组均能改善老年功能性便秘患者的临床主要症状;治疗后两组主要症状积分差值比较(P0.05),具有统计学意义,说明治疗组在改善临床主要症状方面明显优于对照组。(4)在改善临床次要症状积分方面:两组患者分别治疗后,神疲懒言、气短乏力、头晕耳鸣、潮热盗汗积分与治疗前比较,均有显著性差异(P0.05),说明两组均能改善老年功能性便秘患者的临床次要症状;治疗后两组次要症状积分差值比较,除气短乏力积分差值P0.05外,其余P均0.05,具有统计学意义,说明两组在治疗气短乏力方面,治疗效果相当,在改善神疲懒言、头晕耳鸣、潮热盗汗方面,治疗组明显优于对照组。(5)在复发率方面:治疗结束后随访2个月,结果治疗组复发率3.57%,对照组复发率22.73%,两组复发率比较差异具有统计学意义(P0.05),表明治疗组远期疗效明显优于对照组。结论:导师经验方益气养阴润肠汤治疗气阴两虚型老年功能性便秘,在改善临床总疗效、临床总症状、临床主要症状、临床次要症状及复发率方面,其疗效明显优于对照组聚乙二醇4000散剂(福松),值得在临床中推广应用。
[Abstract]:Objective: to observe the improvement of clinical symptoms of Yiqi Yangyin Runchang decoction in elderly patients with functional constipation by comparing with polyethylene glycol 4000 powder (commodity name: Fusong), to study its therapeutic effect and to explore its therapeutic mechanism. Therefore, the safety, effectiveness and long-term curative effect of Yiqi Yangyin Runchang decoction were further evaluated, and the scientific basis for clinical application was provided. Methods: from January 2015 to January 2016, 60 elderly constipation patients who were admitted to Henan University of traditional Chinese Medicine at the second affiliated Hospital of Henan University of traditional Chinese Medicine were selected and made into EXCEL table according to the number of patients with constipation due to deficiency of Qi and Yin. We divided the treatment group (30 cases) into treatment group (30 cases) and control group (30 cases). The treatment group was treated with Yiqi Yangyin Runchang decoction and the control group with Fusong. The two groups were treated continuously for one month. The clinical symptoms and adverse reactions of the two groups were recorded in detail. After the treatment, the total curative effect, the clinical symptom score and the relapse after 2 months were evaluated and analyzed by SPSS19.0 software. Results: the total effective rate of the treatment group was 93.33, and the total effective rate was 73.33. By statistical analysis, the total effective rate of the two groups was significantly different from that of the two groups (P 0.05), which showed that the two groups had statistical significance in improving the total clinical efficacy. The treatment group was superior to the control group in improving the total clinical symptom score: after the two groups were treated separately, the clinical total symptom score was compared with that before treatment. There were significant differences between the two groups, indicating that the two groups could improve the total clinical symptoms of the elderly patients with functional constipation, and the difference of the total symptom scores between the two groups was statistically significant after treatment. It shows that the treatment group is obviously superior to the control group in improving the total clinical symptoms.) in improving the clinical main symptom score, the two groups of patients after treatment, defecation interval time, defecation character, The scores of defecation difficulty were significantly different from those before treatment (P 0.05), which indicated that the two groups could improve the main clinical symptoms of senile functional constipation, and the difference between the two groups was statistically significant. It shows that the treatment group is obviously superior to the control group in improving the main clinical symptoms.) in improving the clinical secondary symptom score: after treatment, the patients in the two groups were compared with those before treatment in terms of mental fatigue, asthenia, dizziness and tinnitus, hot flashes and night sweats. There were significant differences between the two groups (P 0.05), which indicated that the two groups could improve the clinical secondary symptoms of the elderly patients with functional constipation, the difference between the two groups in the score of secondary symptoms was significant, except for the difference of asthenia and asthenia (P0.05), the other two groups had statistical significance. The results showed that the two groups had the same therapeutic effect in the treatment of asthenia and asthenia. The treatment group was obviously superior to the control group in the recurrence rate in terms of improving the tired speech, dizziness and tinnitus, and hot tide and night sweating.) at the end of the treatment, the treatment group was followed up for 2 months. Results the recurrence rate was 3.57 in the treatment group and 22.73 in the control group. The difference of the recurrence rate between the two groups was statistically significant (P 0.05), which indicated that the long-term curative effect of the treatment group was obviously better than that of the control group. Conclusion: the treatment of functional constipation of senile patients with deficiency of Qi and yin by the tutor's experience prescription "Yiqi Yangyin Runchang decoction" can improve the total clinical curative effect, clinical symptoms, main clinical symptoms, clinical secondary symptoms and recurrence rate. Its curative effect is obviously superior to that of the control group, which is worth popularizing in clinic.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

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