益肾健脾通络法治疗慢性肾炎蛋白尿脾肾气虚证的回顾性分析

发布时间：2018-05-26 11:28

  本文选题：益肾健脾通络法 + 慢性肾小球肾炎　； 参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:本研究旨在观察益肾健脾通络法治疗脾肾气虚型慢性肾小球肾炎蛋白尿的临床疗效。材料与方法:使用电子病历系统,收集2014年1月份—2016年1月份,就诊于辽宁中医药大学附属医院病房和门诊,并被确诊为慢性肾小球肾炎的患者,依据本实验研究所制定的诊断标准、纳入标准以及排除标准,收录仅使用基础治疗配以中成药黄葵胶囊的患者,共33例,作为对照组;收录在对照组治疗基础上服用由参芪地黄汤加味组成的中药复方益肾健脾通络方的患者,共35例,作为治疗组。疗程为两周,观察患者治疗前后的症状、体征,统计分析两组患者治疗前后的中医症候、24小时尿蛋白定量,及血尿便常规、肝功能、肾功能、心电图等安全性指标,从而评价益肾健脾通络法治疗脾肾气虚型慢性肾炎蛋白尿的临床疗效及安全性。结果:1.西医临床疗效:治疗组临床控制9例,显效13例,有效9例,无效4例,总有效率为88.57%;对照组临床控制3例,显效9例,有效8例,无效13例,总有效率为60.61%,治疗组西医临床疗效明显优于对照组(P0.05)。2.24小时尿蛋白定量:治疗组患者的24h UTP较治疗前有明显改善(P0.05),且疗效相比对照组更加显著(P0.05)。3.中医症侯疗效:治疗组临床痊愈7例,显效9例,有效13例,无效6例,总有效率为82.86%,对照组临床痊愈3例,显效6例,有效12例,无效12例,总有效率为63.64%,治疗组的中医症候疗效明显高于对照组(P0.05)。4.益肾健脾通络法治疗慢性肾炎蛋白尿脾肾气虚证的安全性良好。结论:益肾健脾通络法治疗中医证属脾肾气虚型慢性肾小球肾炎蛋白尿的效果显著,使该病患者临床症状及体征明显好转,疗效肯定,安全性良好,值得推广。
[Abstract]:Objective: to observe the clinical effect of tonifying kidney and invigorating spleen and dredging collaterals on chronic glomerulonephritis with deficiency of spleen and kidney qi. Materials and methods: patients with chronic glomerulonephritis were collected from January 2014 to January 2016 in the wards and outpatient clinics of affiliated Hospital of Liaoning University of traditional Chinese Medicine, using the electronic medical record system. According to the diagnostic criteria, the inclusion criteria and the exclusion criteria, 33 patients with basic treatment and Chinese patent medicine Huangkui capsule were included as the control group. A total of 35 patients who were treated with Shenqi Dihuang decoction and Yishen Jianpi Tongluo prescription on the basis of the control group were included as the treatment group. The course of treatment was two weeks. The symptoms and signs of the patients before and after treatment were observed, and the symptoms of TCM before and after treatment were statistically analyzed. The quantitative analysis of urine protein in 24 hours and the safety indexes of hematuria routine, liver function, renal function, electrocardiogram, etc. Objective: to evaluate the clinical efficacy and safety of tonifying kidney and invigorating spleen and dredging collaterals in the treatment of chronic nephritis with deficiency of spleen and kidney qi. The result is 1: 1. The clinical efficacy of western medicine: in the treatment group, 9 cases were clinically controlled, 13 cases were effective, 9 cases were effective, 4 cases were ineffective, and the total effective rate was 88.57 cases, while in the control group, there were 3 cases of clinical control, 9 cases of remarkable effect, 8 cases of effective and 13 cases of failure. The total effective rate was 60.61.The clinical curative effect of western medicine in the treatment group was obviously better than that in the control group (P0.05n.2.24h): the 24h UTP of the patients in the treatment group was significantly improved than that before treatment, and the curative effect was more significant than that of the control group. In the treatment group, 7 cases were cured, 9 cases were effective, 13 cases were effective, 6 cases were ineffective, the total effective rate was 82.86 cases. In the control group, 3 cases were clinically cured, 6 cases were markedly effective, 12 cases were ineffective. The total effective rate was 63.64, and the curative effect of TCM symptom in the treatment group was significantly higher than that in the control group (P 0.05. 4). The method of tonifying kidney and invigorating spleen and dredging collaterals is safe in the treatment of chronic nephritis with deficiency of spleen and kidney qi. Conclusion: the treatment of chronic glomerulonephritis with deficiency of spleen and kidney qi and deficiency of spleen and kidney by the method of tonifying the kidney and invigorating the spleen and dredging collaterals has a remarkable effect on proteinuria. The clinical symptoms and signs of the patients with chronic glomerulonephritis can be improved obviously.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
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本文编号：1937068