参芪解毒膏治疗脾肾虚衰、浊毒潴留型慢性肾衰早中期的临床疗效观察

发布时间：2018-05-26 19:40

本文选题：参芪解毒膏 + 脾肾虚衰　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察参芪解毒膏作为温阳益气、解毒泻浊作用的复方对脾肾虚衰、浊毒潴留型慢性肾衰早中期的临床治疗效果,进一步指导医师在临床中对于方药的选择与应用。方法:将70例符合脾肾虚衰、浊毒潴留型慢性肾衰早中期的患者随机分为治疗组(35例)和对照组(35例),治疗组在一般治疗的基础上加用参芪解毒膏;对照组在一般治疗的基础上加用尿毒清颗粒。观察两组患者治疗前后的临床症状积分及血肌酐、血尿酸、内生肌酐清除率、血尿素氮、血红蛋白、血白蛋白、总胆固醇、甘油三酯、24小时尿蛋白定量等实验室指标的改善情况。结果:1.治疗组治疗后的总疗效有效率为88.57%,优于对照组的74.29%(P0.05);2.对倦怠乏力/气短懒言、畏寒肢冷、食少纳呆、腰部冷痛、腰膝酸软、夜尿清长、大便不实这几组症状的疗效,参芪组较尿毒清组有显著优势(P0.01);3.治疗后两组均可降低BUN、Scr、Ccr、UA、CO2CP、TC、TG、UTP水平,提高Hb、ALb水平,参芪组在降低UTP,提高ALb方面优于对照组(P0.05)。结论:参芪解毒膏可以有效地减少尿微量白蛋白,降低BUN、Scr、Ccr、UA、CO2CP、TC、TG、UTP的水平,同时亦可提高Hb、ALb水平,改善肾脏功能,延缓慢性肾衰的进程,为治疗脾肾虚衰、浊毒潴留型慢性肾衰提供了新的有效途径。
[Abstract]:Objective: to observe the clinical therapeutic effect of Shenqi jiedu ointment (SJO) on chronic renal failure with deficiency of spleen and kidney and retention of turbid poison in early and middle period, and to guide doctors to choose and apply prescriptions in clinic. Methods: 70 cases of chronic renal failure with deficiency of spleen and kidney and retention of turbid toxin were randomly divided into treatment group (n = 35) and control group (n = 35). The treatment group was treated with Shenqi jiedu ointment on the basis of general treatment. The control group was treated with Niaoduqing granules on the basis of general treatment. The clinical symptom scores, serum creatinine, serum uric acid, endogenous creatinine clearance rate, blood urea nitrogen, hemoglobin, serum albumin, total cholesterol were observed before and after treatment. Improvement of 24-hour urinary protein quantification and other laboratory indexes of triglyceride. The result is 1: 1. The total effective rate of the treatment group was 88.57, which was better than that of the control group (74.29%). The effects of fatigue / shortness of breath, cold limbs, low food intake, cold waist pain, sore waist knee, long night urine and untrue stool in Shenqi group were significantly higher than those in Niuduqing group (P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01). After treatment, both groups could decrease the level of UTP and increase the level of HbTG-ALB in both groups. Shenqi group was superior to the control group in terms of reducing UTP and increasing ALb (P 0.05). Conclusion: Shenqi jiedu ointment can effectively reduce urinary microalbuminuria, decrease the level of UTP of BUNG Scrr CcrC UAUACO 2CPN TGG, increase HB level, improve renal function, delay the process of chronic renal failure, in order to treat spleen and kidney deficiency failure. Chronic renal failure with turbid toxin retention provides a new effective approach.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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