土茯苓单味治疗湿热蕴结型急性痛风性关节炎的疗效观察

发布时间：2018-05-26 20:59

  本文选题：土茯苓 + 湿热蕴结　； 参考：《广州中医药大学》2017年硕士论文

【摘要】：目的:古代医家辩证用药的经验中,含有土茯苓的复方中药汤剂的治疗效果确切,为针对湿热蕴结型急性期痛风性关节炎的患者,给予土茯苓单味汤剂口服,观察对比治疗前后患者的VAS评分、白细胞计数、血沉、C反应蛋白、血尿酸实验室检验指标的波动情况,为进一步肯定土茯苓单味汤剂的疗效提供更有力的证据。方法:挑选来自广州中医药大学附属骨伤科医院,自2016年2月至2017年2月期间,符合该研究的80例患有湿热蕴结型急性期痛风性关节炎的患者,经过随机化配平,均分为治疗组40例及对照组40例,于治疗前测定其VAS评分、白细胞计数、血沉、C反应蛋白、血尿酸,治疗组采用土茯苓单味治疗,选广东产土茯苓100g,加水500ml,煎取200ml,1剂/日,分早晚两次饭后温服,联合依托考昔片口服60mg/次,1次/d;对照组单纯给予依托考昔片口服60mg/次,1次/d。1周为1疗程,共治疗2周。分别在1周后、2周后,两组患者复诊分别时测定VAS评分、白细胞、血沉、C反应蛋白、血尿酸。比较分析组间及治疗前后各个指标波动情况。结果:1.两组患者在治疗前VAS评分、白细胞、血沉、C反应蛋白、血尿酸无明显差异,差异无统计学意义(P0.05),组间有可比性。2.治疗组及对照组的患者经治疗后的VAS评分、白细胞、血沉、C反应蛋白、血尿酸指标较治疗前显著下降,有明显差异(P0.05)。治疗组各指标较对照组下降明显,尤其是血尿酸,差异有统计学意义(P0.05)。结论:湿热蕴结型急性期痛风性关节炎患者经土茯苓单味汤剂联合依托考昔片治疗后,较单纯依托考昔片治疗具有更好的疗效,并且能进一步降低白细胞、血沉、C反应蛋白,尤其是血尿酸。
[Abstract]:Objective: in the experience of dialectical medicine of ancient physicians, the curative effect of compound traditional Chinese medicine decoction containing Tupia cocos is definite. In order to treat the patients with acute gouty arthritis of dampness and heat accumulation type in acute stage, Tuckaoling decoction is given orally. The fluctuation of VAS score, white blood cell count, erythrocyte sedimentation rate C reactive protein and blood uric acid laboratory test were observed and compared before and after treatment. Methods: from February 2016 to February 2017, 80 patients with acute gouty arthritis of damp-heat accumulation type were selected from the affiliated Orthopedic and Trauma Hospital of Guangzhou University of traditional Chinese Medicine. All patients were divided into treatment group (n = 40) and control group (n = 40). Their VAS score, white blood cell count, erythrocyte sedimentation rate C reactive protein, blood uric acid were measured before treatment. The patients in the control group were treated with etacoxib orally for 1 / d / d for 1 / 2 / d respectively, while the control group were given etacoxib orally for 1 / d / 1 / d ~ (1) week for a course of treatment for 2 weeks. After 1 week and 2 weeks, the VAS score, white blood cell, erythrocyte sedimentation rate C reactive protein and uric acid were measured. To compare and analyze the fluctuation of each index between groups and before and after treatment. The result is 1: 1. There was no significant difference in VAS score, leukocyte, erythrocyte sedimentation rate C reactive protein and serum uric acid between the two groups before treatment, but there was no significant difference between the two groups (P 0.05). The VAS score, WBC, ESR C reactive protein and serum uric acid index of the patients in the treatment group and the control group were significantly lower than those before treatment (P 0.05). The indexes of the treatment group were significantly lower than that of the control group, especially the serum uric acid, the difference was statistically significant (P 0.05). Conclusion: the patients with acute gouty arthritis of dampness and heat accumulation type can get better curative effect after treatment with TuPoria Ling single decoction combined with relying on Coxie tablet, and can further reduce white blood cell, erythrocyte sedimentation rate and C-reactive protein, compared with only relying on Coxie tablet, and can further reduce WBC, erythrocyte sedimentation rate and C-reactive protein. Especially blood uric acid.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
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本文编号：1938875