NO及NOS与气阴两虚型功能性便秘相关性及芪榔方的干预作用

发布时间：2018-05-26 22:25

本文选题：功能性便秘 + 气阴两虚型　；参考：《世界中西医结合杂志》2017年04期

【摘要】：目的观察一氧化氮(NO)及一氧化氮合成酶(NOS)亚型与气阴两虚型功能性便秘(FC)的相关性,并进一步研究芪榔方对NO及NOS的调节作用。方法首先以40例健康人为对照(健康人组),观察NO及NOS亚型在健康人与气阴两虚型FC患者(FC组)血清含量差异;其次将符合纳入气阴两虚型FC诊断标准的FC组80例受试者按随机数字设置对照组及治疗组,治疗组用芪榔方,对照组用乳果糖口服溶液,皆以8周为1个疗程。分别在治疗前、治疗8周后检测血清NO及NOS亚型的含量变化。结果 FC组患者与健康人组比较,血清NO、TNOS、iNOS含量呈显著增高趋势(P0.05),血清cNOS含量无明显差异(P0.05)。FC患者治疗组与对照组均能显著降低患者血清中升高的NO、TNOS、iNOS(P0.05),且治疗组疗效优于对照组(P0.05)。结论气阴两虚型FC患者血清升高的NO可能主要由iNOS合成,芪榔方具有调节血清NO及NOS亚型的作用。
[Abstract]:Objective to observe the relationship between nitric oxide (no) and nitric oxide synthase (NOS) subtypes and functional constipation (FCCs) of deficiency of qi and yin, and to study the regulatory effect of Qilu recipe on no and NOS. Methods the serum levels of no and NOS subtypes were observed in 40 healthy people as control group and in FC group with deficiency of qi and yin. Secondly, 80 patients in FC group were randomly divided into two groups: control group and treatment group. The treatment group was treated with Qilu recipe and the control group with lactofructose oral solution for 8 weeks as a course of treatment. Serum no and NOS subtypes were measured before and 8 weeks after treatment. Results compared with the healthy control group, the serum NONTNOSN iNOS content in the FC group was significantly higher than that in the control group. There was no significant difference in serum cNOS content between the FC group and the control group. Both the treatment group and the control group could significantly reduce the elevated NONOS iNOS content in the serum of the patients, and the therapeutic effect of the treatment group was better than that of the control group (P 0.05). Conclusion the elevated no in serum of FC patients with deficiency of qi and yin may be mainly synthesized by iNOS. Qilu recipe has the effect of regulating serum no and NOS subtypes.
【作者单位】：上海中医药大学附属市中医医院脾胃病科;
【基金】：国家自然科学基金(81573775) 上海市“新百人”人才计划项目(XBR2013120)
【分类号】：R256.35

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