三七制剂对血小板功能影响的系统评价

发布时间：2018-05-31 07:39

  本文选题：三七 + 血小板　； 参考：《中国中药杂志》2017年21期

【摘要】：该研究采用系统评价的方式,评价三七制剂对血小板相关指标的影响作用。通过计算机检索中文全文期刊数据库(CNKI),万方数据库(Wan Fang),中国生物医学文献数据库(Sino Med),the Cochrane Library,Pub Med,EMbase数据库,搜集三七制剂对血小板相关指标影响的随机对照试验(randomized controlled trial,RCT),检索时限均为建库至2017年5月,由2位研究者独立进行文献筛选、资料提取及纳入研究质量评价。最终纳入36个RCT,结局指标包括血小板聚集率(MPAR)、血小板计数(PLT)、血浆血栓烷B2(TXB2)与不良反应。分析结果显示三七制剂与安慰剂[SMD=1.84,95%CI(1.33,2.35),P0.000 01]与非抗血小板西药[SMD=0.74,95%CI(0.19,1.28),P=0.008]对比可降低MPAR;与非抗血小板西药联用可降低MPAR[SMD=2.34,95%CI(1.14,3.54),P=0.000 1],TXB2(SMD=1.25,95%CI(0.75,1.76),P0.000 01];与抗血小板西药联用可更好降低MPAR[SMD=0.93,95%CI(0.58,1.29),P0.000 01],TXB2[SMD=1.16,95%CI(0.74,1.58),P0.000 01]。在出血性不良反应方面,三七制剂联用抗血小板西药未增加生出血风险。结果表明,三七制剂可降低MPAR与TXB2,且三七制剂与西药常规联用可增加疗效。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。
[Abstract]:The effect of Panax notoginseng on platelet-related indexes was evaluated by systematic evaluation. The Chinese full text periodical database (CNKI), Wanfang database (Wan Fang), the Chinese biomedical literature database (Sino Meden) and the Cochrane Library (Cochrane Library) are searched by computer. Random controlled triallocytes (RCTT) were collected from random controlled trials of Panax notoginseng (PNS) on platelet related indexes. The retrieval time was from the establishment of the database to May 2017. The literature was screened by two researchers independently, and the data were extracted and included in the evaluation of the quality of the study. Finally, 36 RCTs were included, including platelet aggregation rate (MPAR), platelet count (PLT), plasma thromboxane B _ 2 (TXB _ 2) and adverse reactions. 鍒嗘瀽缁撴灉鏄剧ず涓変竷鍒跺墏涓庡畨鎱板墏[SMD=1.84,95%CI(1.33,2.35),P0.000 01]涓庨潪鎶楄��灏忔澘瑗胯嵂[SMD=0.74,95%CI(0.19,1.28),P=0.008]瀵规瘮鍙�闄嶄綆MPAR;涓庨潪鎶楄��灏忔澘瑗胯嵂鑱旂敤鍙�闄嶄綆MPAR[SMD=2.34,95%CI(1.14,3.54),P=0.000 1],TXB2(SMD=1.25,95%CI(0.75,1.76),P0.000 01];涓庢姉琛，

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