“扶正补土”针灸法对脑梗死后虚型抑郁症患者主观情绪和神经递质的影响

发布时间：2018-05-31 09:35

本文选题：扶正补土 + 抑郁症　；参考：《福建中医药大学》2017年硕士论文

【摘要】：目的:观察“扶正补土”针灸法对脑梗死后虚型抑郁症患者的抑郁程度、中医虚型郁证程度、血清5-HT与NE水平的影响,并通过分析其与观察指标的相关性,探讨其可能的作用机制。方法:将符合纳入标准的64例脑梗死后虚型抑郁症患者,采用区组随机化分成两组随机对照的方法研究,治疗组予“扶正补土”针灸法治疗,对照组予单纯针刺法治疗,均以14天为1个疗程,共治疗2个疗程。在治疗前、治疗14天后、治疗28天后分别对患者进行汉密尔顿抑郁量表(HAMD)评分、中医虚型郁证量表评分;在治疗前、治疗28天后对患者进行血清5-羟色胺(5-HT)和去甲肾上腺素(NE)水平测定,并运用SPSS20.0软件进行统计分析。结果:(1)治疗组与对照组的汉密尔顿抑郁量表(HAMD)评分、中医虚型郁证量表评分、血清5-HT和NE水平在治疗后均有改善,与治疗前相比,有显著性差异(P0.01)。(2)治疗14天后,治疗组的汉密尔顿抑郁量表(HAMD)评分、中医虚型郁证量表评分分别与对照组相比,无显著性差异(P0.05)。(3)治疗28天后,治疗组的汉密尔顿抑郁量表(HAMD)评分、血清5-HT和NE水平分别与对照组相比,有显著差异(P0.01);但组间中医虚型郁证量表评分比较,无显著性差异(P0.05)。(4)两组治疗前的汉密尔顿抑郁量表(HAMD)评分和中医虚型郁证量表评分呈正相关(P0.05),5-HT和NE水平也呈正相关(P0.01),但这两组之间呈负相关(P0.05)。(5)治疗后,治疗组的中医虚型郁证量表评分与血清5-HT水平无明显负相关(P0.05);对照组的中医虚型郁证量表评分与血清NE水平无明显负相关(P0.05)。结论:(1)“扶正补土”针灸法能够显著降低汉密尔顿抑郁量表(HAMD)和中医虚型郁证量表的评分,且明显提高血清中5-羟色胺(5-HT)和去甲肾上腺素(NE)的水平。(2)“扶正补土”针灸法对患者的抑郁程度和血清中NE的水平起到正相关的调节作用。(3)“扶正补土”针灸法无明显不良反应,治疗脑梗死后虚型抑郁症患者安全、有效。
[Abstract]:Objective: to observe the effect of "Fuzheng Butu" acupuncture and moxibustion method on depression degree of deficiency type after cerebral infarction, depression degree of TCM deficiency type, serum 5-HT and NE levels, and to analyze their correlation with observed indexes. The possible mechanism of its action was discussed. Methods: 64 patients with depressive disorder after cerebral infarction were randomly divided into two groups. The treatment group was treated with acupuncture and moxibustion method of "Fuzheng Butu" and the control group was treated with simple acupuncture. All patients were treated with 14 days as a course of treatment. Before treatment, 14 days after treatment, 28 days after treatment, the patients were evaluated with Hamilton Depression scale (Hamd), TCM deficiency Depression scale (TCM), before treatment, After 28 days of treatment, the serum serotonin 5-HT and noradrenaline (NE) levels were measured and analyzed by SPSS20.0 software. Results the scores of Hamilton Depression scale (Hamd), TCM deficiency Depression scale, Serum 5-HT and NE levels in the treatment group and the control group were improved after treatment, and there was significant difference between the treatment group and the control group after 14 days of treatment. There was no significant difference in the scores of Hamilton Depression scale (Hamd) and TCM deficiency Depression scale (TCM Depression scale) between the treatment group and the control group after 28 days of treatment, there was no significant difference in the scores of the treatment group and the control group (P < 0.05). After 28 days of treatment, the treatment group had the score of the Hamilton Depression scale (Hamd). The serum levels of 5-HT and NE were significantly different from those of the control group (P 0.01), but the scores of TCM deficiency depression scale were compared between the two groups. There was no significant difference between the two groups before treatment (P 0.05).) the scores of Hamilton Depression scale (Hamd) before treatment and the scores of TCM deficiency Depression scale were positively correlated with the levels of 5-HT and NE, but there was a negative correlation between the two groups after treatment, however, there was a negative correlation between the two groups after treatment. There was no significant negative correlation between TCM deficiency depression scale score and serum 5-HT level in the treatment group, and there was no significant negative correlation between the TCM deficiency depression scale score and the serum NE level in the control group. Conclusion the acupuncture and moxibustion method of "Fuzheng Butu" can significantly reduce the scores of Hamilton Depression scale (Hamd) and TCM deficiency Depression scale. The level of serotonin 5-HT) and noradrenaline (NEN) were significantly increased. (2) "Fuzheng Butu" acupuncture and moxibustion method has a positive correlation to the depression degree of patients and the level of NE in serum. 3) "Fuzheng Butu" acupuncture and moxibustion method "Fuzheng Butu" acupuncture and moxibustion method of "Fuzheng Butu" acupuncture and moxibustion method No obvious adverse reactions, It is safe and effective to treat depressive patients with deficiency type after cerebral infarction.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R246.6

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