中药注射剂的临床应用分析以及丹红注射液治疗糖尿病性冠心病疗效的Meta分析

发布时间：2018-05-31 13:18

本文选题：中药注射剂 + 用药频度　；参考：《山西医科大学》2017年硕士论文

【摘要】：目的:分析某中医院2013-2016中药注射剂临床应用情况,并选取丹红注射液作为典型药物,对其治疗糖尿病性冠心病的临床疗效进行Meta分析,为临床制定合理治疗决策提供参考。方法:根据中医药辨证理论对某中医院常用中药注射剂进行药理分类。统计分析某中医院所用中药注射剂销售额、数量、用药频度(DDDs)、日用药金额(DDC)以及中药注射剂销售金额占全院药品销售总金额的百分比。利用计算机数据库检索文献并筛选,对纳入符合研究标准的文献进行方法学质量评价后,应用RveMan5.3软件,采用随机效应模型对纳入文献进行Meta分析。结果:2013-2016年,某中医院中药注射剂品种数分别为31、32、33、33,中药注射剂销售额和中药销售总金额以及药品销售总金额三年内分别增长了23.85%和16.76%和10.43%。丹红注射液治疗糖尿病合并冠心病Meta分析共纳入10篇文献,在心绞痛缓解总有效率和显效率方面,丹红注射液+常规疗法VS常规疗法异质性结果分别为,P=0.900.1,I2=0%,OR[95%CI]为5.06[3.29,7.79]和P=0.800.05,I2=0%,综合结果优势比(Odds Ratio)OR[95%CI]为2.20[1.63,2.96],差异有统计学意义(P0.05)。在心电图改善总有效率和显效率方面,丹红注射液+常规疗法VS常规疗法分别为OR[95%CI]为2.33[1.52,3.56](P0.05)和OR[95%CI]为1.82[1.23,2.70](P0.05)。结论:该中医院中药注射剂应用呈逐年上升趋势,且应用在合理范围。丹红注射液联合常规治疗在心绞痛缓解和心电图改善方面均优于常规治疗。
[Abstract]:Objective: to analyze the clinical application of traditional Chinese medicine injection in a certain Chinese medicine hospital 2013-2016, and select Danhong injection as a typical drug to analyze the clinical effect of traditional Chinese medicine injection in treating diabetic coronary heart disease by Meta, and to provide reference for making rational treatment decision in clinic. Methods: according to the theory of TCM syndrome differentiation, the pharmacological classification of traditional Chinese medicine injection in a Chinese medicine hospital was carried out. The sales volume, quantity, frequency of drug use, daily amount of DDCand the percentage of sales amount of Chinese medicine injection to the total amount of drug sales in a Chinese medicine hospital were analyzed statistically. The literature was searched and screened by computer database. After evaluating the methodological quality of the literature that met the research standard, the Meta analysis was carried out by using the RveMan5.3 software and the random effect model. Results in 2013-2016, the number of Chinese traditional medicine injections in a certain Chinese medicine hospital was 31 ~ 32X ~ (33), respectively. The sales of traditional Chinese medicine injection, the total amount of Chinese medicine sales and the total sum of sales of Chinese medicine increased 23.85%, 16.76% and 10.43% respectively in three years. The Meta analysis of Danhong injection in the treatment of diabetes mellitus with coronary heart disease was included in 10 articles. The total effective rate and effective rate of angina pectoris relief were analyzed. The heterogeneity of vs conventional therapy in Danhong injection was 5.06 [3.297.79] and 0.800.05% (95%CI), respectively. The heterogeneity of conventional therapy vs conventional therapy of Danhong injection was 2.20 [95%CI] 2.20 [1.632.96], the difference was statistically significant. In improving the total effective rate and effective rate of electrocardiogram, the OR [95%CI] and OR [95%CI] of Danhong injection conventional therapy vs were 2.33 [1.52 卤3.56] and 1.82 [1.232.70] respectively. Conclusion: the application of traditional Chinese medicine injection in this hospital is increasing year by year and applied in a reasonable range. Danhong injection combined with conventional therapy is superior to conventional therapy in angina pectoris relief and ECG improvement.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

【参考文献】